亜鉛：男性型・女性型脱毛症（AGA）

A エビデンス複数の大規模臨床試験が一貫して有意な効果を示しています。

合計49,138名の参加者を対象とした29件の研究（メタアナリシス1件、RCT 3件を含む）に基づく。研究間で結果にばらつきが見られる。

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結論

Research on zinc for androgenetic alopecia is mixed — while zinc is important for hair follicle health, supplementation alone has not been clearly shown to improve pattern hair loss.

Mixed results across 29 studies, including a meta-analysis showing inconsistent findings
Some studies find lower zinc in people with pattern hair loss, others do not
Zinc is usually studied as part of multi-ingredient formulas, making its individual contribution unclear
Supplementation may only help if a zinc deficiency is confirmed

Key Study Findings

animal study

Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …

Dose: zinc and/or selenium supplementation; doses not specified in abstract vs: Placebo 効果: None None

Review

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.

Dose: None vs: Placebo 効果: None None

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo 効果: None None

cross-sectional study

Zinc Status in Kurdish Adults With Hair Loss.

Dose: None vs: Placebo 効果: None None

systematic_review

Micronutrients and Androgenetic Alopecia: A Systematic Review.

Dose: variable across included studies vs: Placebo 効果: vitamin B, D, iron, zinc deficiencies associated with increased AGA risk; supplementation showed pot None

in vitro study

Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 …

Dose: not specified vs: Placebo 効果: melanin production 130.18 ± 9.13% of control; NO secretion 1.43 ± 0.05 µM p > 0.05 (vs theophylline, no

Key Statistics

研究数

49138

参加者数

↔

Mixed

グレード

Referenced Papers

Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights from multiomics analysis. Other

Environment international 2026

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. Review

Current medicinal chemistry 2025 5 件の引用

Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications. Review

Biomedicine & pharmacotherapy … 2025 4 件の引用

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Micronutrients and Androgenetic Alopecia: A Systematic Review. Systematic Review

Molecular nutrition & … 2024 7 件の引用

Zinc Status in Kurdish Adults With Hair Loss. Other

Cureus 2024 1 件の引用

A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch. Other

Bioactive materials 2023 108 件の引用

Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. Other

Theranostics 2023 65 件の引用

Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 … Other

Plants (Basel, Switzerland) 2023 14 件の引用

Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … Other

Italian journal of … 2023 3 件の引用

Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study. Other

European journal of … 2022 34 件の引用

Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, … RCT

Journal of cosmetic … 2022 11 件の引用

The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. Review

Human nutrition & … 2022 9 件の引用

Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. Other

JAAD international 2022 6 件の引用

Association between serum zinc levels and androgenetic alopecia: a systematic review and meta-analysis. Meta-Analysis

Journal of cosmetic … 2022 5 件の引用

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. Other

Dermatology reports 2022 4 件の引用

A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. RCT

Italian journal of … 2022 2 件の引用

Erosive pustular dermatosis of the scalp: causes and treatments. Review

International journal of … 2021 23 件の引用

Vulvar Fordyce adenitis: A cohort of 45 women. Other

Annales de dermatologie … 2021 4 件の引用

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy's Effectiveness. Other

Diagnostics (Basel, Switzerland) 2020 13 件の引用

Dietary zinc supplement militates against ketamine-induced behaviours by age-dependent modulation of oxidative stress and acetylcholinesterase activity in mice. Other

Pharmacological reports : … 2020 7 件の引用

A Matched Case-Control Study of Zinc Levels in Androgenetic Alopecia and Alopecia Areata: Is There a Need to Do Routine … Other

Skinmed 2020

Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee. Meta-Analysis

The Journal of … 2019 101 件の引用

Serum biotin and zinc in male androgenetic alopecia. Other

Journal of cosmetic … 2019 15 件の引用

Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study. Other

Indian journal of … 2018 26 件の引用

Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. Other

International journal of … 2017 43 件の引用

Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: … Other

Journal of research … 2017 12 件の引用

Low plasma zinc levels in androgenetic alopecia. Other

Indian journal of … 2017 10 件の引用

Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Other

International journal of … 2016 28 件の引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 件の引用

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss. Other

Journal of ethnopharmacology 2015 37 件の引用

BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia. Other

Journal of trace … 2014 62 件の引用

Evidence for supplemental treatments in androgenetic alopecia. Other

Journal of drugs … 2014 26 件の引用

Analysis of serum zinc and copper concentrations in hair loss. Other

Annals of dermatology 2013 114 件の引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 件の引用

[Effectiveness of the treatment plan for androgenetic alopecia]. Other

Georgian medical news 2007

The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. Review

Journal of the … 2006 255 件の引用

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. Other

International journal of … 2002 53 件の引用

Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. Other

Clinical and experimental … 1989 140 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-11 mg/day
hairloss:: 15-30 mg/day

上限量： 40 mg/day

研究で検討された用量

用量	期間	効果	N
zinc and/or selenium supplementation; doses not specified in abstract	--	Positive	--
None	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Neutral	--
variable across included studies	--	Mixed	--
not specified	--	Positive	--
Daily tablet (L-cystine, L-methionine, liposomal glutathione, zinc, copper, iron, selenium, ubidecar	24 weeks	Positive	20
Topical lotion containing zinc and arginine (concentration not specified)	23 weeks	Positive	40

推奨摂取タイミング： With meals to minimize stomach upset; separate from iron and calcium by 2 hours

Safety & Side Effects

報告されている副作用

⚠ Nausea and vomiting (especially on an empty stomach)
⚠ Metallic taste in the mouth
⚠ Copper depletion with chronic high-dose use
⚠ Headache and diarrhea

既知の相互作用

● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)

耐容上限摂取量： 40 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does 亜鉛 help with 男性型・女性型脱毛症（AGA）?

Based on 33 studies with 49,138 participants, there is strong evidence from multiple clinical trials that 亜鉛 may support 男性型・女性型脱毛症（AGA） management. Our evidence grade is A (Strong Evidence).

How much 亜鉛 should I take for 男性型・女性型脱毛症（AGA）?

Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 亜鉛?

Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use, Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 亜鉛 and 男性型・女性型脱毛症（AGA）?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 49,138 total participants. The overall direction of effect is mixed.

に関する他の成分：男性型・女性型脱毛症（AGA）

ミノキシジル A フィナステリド A PRP療法 A デュタステリド A オメガ3脂肪酸 A マイクロニードリング A

亜鉛他の症状・状態について

円形脱毛症 F 休止期脱毛症 F

総合評価

合計49,138名の参加者を対象とした29件の研究（メタアナリシス1件、RCT 3件を含む）に基づく。研究間で結果にばらつきが見られる。

Evidence Strength92%

High confidence

研究の内訳

RCT (2)Meta (2)Other (29)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：男性型・女性型脱毛症（AGA）

詳しく見る

References

[1] Jing Ma et al.. Environ Int. 2026. Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights from multiomics analysis. doi:10.1016/j.envint.2025.109975 PubMed
[2] Geir Bjørklund et al.. Curr Med Chem. 2025. Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. doi:10.2174/0109298673348175250214054101 PubMed
[3] Michael Kenneth Lawson. Biomed Pharmacother. 2025. Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications. doi:10.1016/j.biopha.2025.118055 PubMed
[4] Rosa M Ortega et al.. Nutr Hosp. 2025. [Nutrition in improving sleep quality and fighting insomnia]. doi:10.20960/nh.06090 PubMed
[5] Ruilong Wang et al.. Mol Nutr Food Res. 2024. Micronutrients and Androgenetic Alopecia: A Systematic Review. doi:10.1002/mnfr.202400652 PubMed
[6] Hivi Mahmoud et al.. Cureus. 2024. Zinc Status in Kurdish Adults With Hair Loss. doi:10.7759/cureus.67264 PubMed
[7] Zhaowenbin Zhang et al.. Bioact Mater. 2023. A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch. doi:10.1016/j.bioactmat.2022.12.007 PubMed
[8] Yating Yang et al.. Theranostics. 2023. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. doi:10.7150/thno.84118 PubMed
[9] Warintorn Ruksiriwanich et al.. Plants (Basel). 2023. Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 … doi:10.3390/plants12030653 PubMed
[10] Michela Starace et al.. Ital J Dermatol Venerol. 2023. Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … doi:10.23736/S2784-8671.22.07416-3 PubMed
[11] Yiwen Zhang et al.. Eur J Epidemiol. 2022. Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study. doi:10.1007/s10654-022-00922-0 PubMed
[12] Julia Welzel et al.. J Cosmet Dermatol. 2022. Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, … doi:10.1111/jocd.14158 PubMed
[13] Noor Altooq et al.. Hum Nutr Metab. 2022. The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. doi:10.1016/j.hnm.2022.200141 PubMed
[14] Elizabeth J Klein et al.. JAAD Int. 2022. Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. doi:10.1016/j.jdin.2022.08.013 PubMed
[15] Hua-Ching Chang et al.. J Cosmet Dermatol. 2022. Association between serum zinc levels and androgenetic alopecia: a systematic review and meta-analysis. doi:10.1111/jocd.14564 PubMed
[16] Mohammed Al Abadie et al.. Dermatol Reports. 2022. Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. doi:10.4081/dr.2022.9512 PubMed
[17] Alfredo Rossi et al.. Ital J Dermatol Venerol. 2022. A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. doi:10.23736/S2784-8671.21.06915-7 PubMed
[18] Katrice M Karanfilian et al.. Int J Dermatol. 2021. Erosive pustular dermatosis of the scalp: causes and treatments. doi:10.1111/ijd.14955 PubMed
[19] F Poizeau et al.. Ann Dermatol Venereol. 2021. Vulvar Fordyce adenitis: A cohort of 45 women. doi:10.1016/j.annder.2021.04.001 PubMed
[20] Irina N Kondrakhina et al.. Diagnostics (Basel). 2020. Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy's Effectiveness. doi:10.3390/diagnostics10050336 PubMed
[21] Olakunle J Onaolapo et al.. Pharmacol Rep. 2020. Dietary zinc supplement militates against ketamine-induced behaviours by age-dependent modulation of oxidative stress and acetylcholinesterase activity in mice. doi:10.1007/s43440-019-00003-2 PubMed
[22] Ludmila Ribeiro Pedrosa et al.. Skinmed. 2020. A Matched Case-Control Study of Zinc Levels in Androgenetic Alopecia and Alopecia Areata: Is There a Need to Do Routine … PubMed
[23] Enrico Carmina et al.. J Clin Endocrinol Metab. 2019. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee. doi:10.1210/jc.2018-02548 PubMed
[24] Fatma Mohamed El-Esawy et al.. J Cosmet Dermatol. 2019. Serum biotin and zinc in male androgenetic alopecia. doi:10.1111/jocd.12865 PubMed
[25] Samer A Dhaher et al.. Indian J Dermatol. 2018. Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study. doi:10.4103/ijd.IJD_624_16 PubMed
[26] Dinesh Gowda et al.. Int J Trichology. 2017. Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. doi:10.4103/ijt.ijt_48_16 PubMed
[27] Mansour Siavash et al.. J Res Pharm Pract. 2017. Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: … doi:10.4103/jrpp.JRPP_17_17 PubMed
[28] Kumpol Aiempanakit et al.. Indian J Dermatol Venereol Leprol. 2017. Low plasma zinc levels in androgenetic alopecia. doi:10.4103/ijdvl.IJDVL_680_16 PubMed
[29] Tee Wei Siah et al.. Int J Trichology. 2016. Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. doi:10.4103/0974-7753.188033 PubMed
[30] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
[31] Pedro Fong et al.. J Ethnopharmacol. 2015. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss. doi:10.1016/j.jep.2015.10.005 PubMed
[32] Perihan Ozturk et al.. J Trace Elem Med Biol. 2014. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia. doi:10.1016/j.jtemb.2014.03.003 PubMed
[33] Shannon Famenini et al.. J Drugs Dermatol. 2014. Evidence for supplemental treatments in androgenetic alopecia. PubMed
[34] Min Seong Kil et al.. Ann Dermatol. 2013. Analysis of serum zinc and copper concentrations in hair loss. doi:10.5021/ad.2013.25.4.405 PubMed
[35] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
[36] N V Tsiskarishvili et al.. Georgian Med News. 2007. [Effectiveness of the treatment plan for androgenetic alopecia]. PubMed
[37] Leonid Benjamin Trost et al.. J Am Acad Dermatol. 2006. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. doi:10.1016/j.jaad.2005.11.1104 PubMed
[38] C Piérard-Franchimont et al.. Int J Cosmet Sci. 2002. Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. doi:10.1046/j.1467-2494.2002.00145.x PubMed
[39] F B De Waard-van der Spek et al.. Clin Exp Dermatol. 1989. Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. doi:10.1111/j.1365-2230.1989.tb02604.x PubMed

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亜鉛 ： 男性型・女性型脱毛症（AGA）