亜鉛 : 円形脱毛症
F 効果 研究によると、この用途への効果は期待しにくい可能性があります。合計23,495名の参加者を対象とした46件の研究(メタアナリシス3件、RCT 1件を含む)に基づく。研究間で結果にばらつきが見られる。
結論
While people with alopecia areata often have lower zinc levels, research is mixed on whether zinc supplementation helps — it may support overall immune health but is not a reliable solution for alopecia areata.
- Lower zinc levels are consistently found in alopecia areata patients
- Supplementation studies show inconsistent results for hair regrowth
- Zinc plays a role in immune function, which is relevant to autoimmune hair loss
- No large-scale RCT specifically tests zinc supplementation for alopecia areata
Key Study Findings
対象集団: review of nonscarring eyebrow alopecia etiologies and management (1960-2025)
Key Statistics
60
研究数
23876
参加者数
Mixed
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 8-11 mg/day
- hairloss:
- 15-30 mg/day
上限量: 40 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | 4931 |
| None | -- | Positive | -- |
| Tofacitinib 1 mg/kg | -- | Positive | 36 |
| None | -- | Mixed | 7014 |
| None | -- | Neutral | 30 |
| Corticosteroid injections (dose not specified) in transgenic mice | -- | Positive | -- |
推奨摂取タイミング: With meals to minimize stomach upset; separate from iron and calcium by 2 hours
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use
- ⚠ Headache and diarrhea
既知の相互作用
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
耐容上限摂取量: 40 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does 亜鉛 help with 円形脱毛症?
How much 亜鉛 should I take for 円形脱毛症?
Are there side effects of 亜鉛?
How strong is the evidence for 亜鉛 and 円形脱毛症?
Related Evidence
に関する他の成分: 円形脱毛症
亜鉛 他の症状・状態について
References
- [1] Janaya Nelson et al.. J Drugs Dermatol. 2026. Eyebrow Madarosis: An Updated Review of the Etiology and Management, Part I - Nonscarring Disorders. doi:10.36849/JDD.9664 PubMed
- [2] Geir Bjørklund et al.. Curr Med Chem. 2025. Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. doi:10.2174/0109298673348175250214054101 PubMed
- [3] Ruiying Wu et al.. J Cosmet Dermatol. 2025. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. doi:10.1111/jocd.16740 PubMed
- [4] Geir Bjørklund et al.. J Trace Elem Med Biol. 2025. The role of trace elements for the function and health of the skin. doi:10.1016/j.jtemb.2025.127674 PubMed
- [5] Yukiyasu Arakawa et al.. Exp Dermatol. 2025. IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice. doi:10.1111/exd.70074 PubMed
- [6] Deniz Duman Günsay et al.. Cutan Ocul Toxicol. 2025. Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and evaluation of their relationship with … doi:10.1080/15569527.2025.2511723 PubMed
- [7] Xinyi Shao et al.. Nutr Rev. 2025. Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. doi:10.1093/nutrit/nuaf015 PubMed
- [8] Luning Li et al.. Front Pharmacol. 2025. Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata. doi:10.3389/fphar.2025.1507348 PubMed
- [9] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
- [10] Shayan Zufishan et al.. J Pak Med Assoc. 2024. Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. doi:10.47391/JPMA-DUHS-S10 PubMed
- [11] Ying Miao et al.. Altern Ther Health Med. 2024. Association analysis of the IKZF4 gene with Alopecia Areata in the Chinese Han population. PubMed
- [12] Hivi Mahmoud et al.. Cureus. 2024. Zinc Status in Kurdish Adults With Hair Loss. doi:10.7759/cureus.67264 PubMed
- [13] Jovan Lalosevic et al.. Acta Derm Venereol. 2023. Serum Zinc Concentration in Patients with Alopecia Areata. doi:10.2340/actadv.v103.13358 PubMed
- [14] Rhiannon C Miller et al.. J Am Acad Dermatol. 2023. "Shedding" low yield testing for telogen effluvium: A cross-sectional study of 16,381 laboratory results from newly diagnosed patients. doi:10.1016/j.jaad.2023.05.045 PubMed
- [15] Michela Starace et al.. Ital J Dermatol Venerol. 2023. Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) … doi:10.23736/S2784-8671.23.07576-X PubMed
- [16] Fatemeh Mokhtari et al.. J Cosmet Dermatol. 2023. Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study. doi:10.1111/jocd.15994 PubMed
- [17] Michela Starace et al.. Ital J Dermatol Venerol. 2023. Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … doi:10.23736/S2784-8671.22.07416-3 PubMed
- [18] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
- [19] Mohammed Al Abadie et al.. Dermatol Reports. 2022. Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. doi:10.4081/dr.2022.9512 PubMed
- [20] Heba Ahmed Abdelkader et al.. Australas J Dermatol. 2022. Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration. doi:10.1111/ajd.13784 PubMed
- [21] Alfredo Rossi et al.. Ital J Dermatol Venerol. 2022. A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. doi:10.23736/S2784-8671.21.06915-7 PubMed
- [22] Saeed M Alamoudi et al.. Cureus. 2021. Association Between Vitamin D and Zinc Levels With Alopecia Areata Phenotypes at a Tertiary Care Center. doi:10.7759/cureus.14738 PubMed
- [23] A N Abbas. Niger J Clin Pract. 2020. Ginger (Zingiber officinale (L.) Rosc) improves oxidative stress and trace elements status in patients with alopecia areata. doi:10.4103/njcp.njcp_59_19 PubMed
- [24] Paolo Daniele Pigatto et al.. Skin Appendage Disord. 2020. Alopecia Areata and Toxic Metals. doi:10.1159/000507296 PubMed
- [25] Cliff J Harvey. Cureus. 2020. Combined Diet and Supplementation Therapy Resolves Alopecia Areata in a Paediatric Patient: A Case Study. doi:10.7759/cureus.11371 PubMed
- [26] Ludmila Ribeiro Pedrosa et al.. Skinmed. 2020. A Matched Case-Control Study of Zinc Levels in Androgenetic Alopecia and Alopecia Areata: Is There a Need to Do Routine … PubMed
- [27] Vivien Wai Yun Lai et al.. Australas J Dermatol. 2019. Systemic treatments for alopecia areata: A systematic review. doi:10.1111/ajd.12913 PubMed
- [28] Goknur Ozaydin-Yavuz et al.. Indian J Dermatol. 2019. Alopecia Areata Different View; Heavy Metals. doi:10.4103/ijd.IJD_137_18 PubMed
- [29] Jordan M Thompson et al.. Am J Clin Dermatol. 2017. The Role of Micronutrients in Alopecia Areata: A Review. doi:10.1007/s40257-017-0285-x PubMed
- [30] Waishu Jin et al.. J Dermatol. 2017. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis. doi:10.1111/1346-8138.13705 PubMed
- [31] Youichi Ogawa et al.. Arch Biochem Biophys. 2016. Zinc and skin biology. doi:10.1016/j.abb.2016.06.003 PubMed
- [32] Nermeen S A Abdel Fattah et al.. Int J Dermatol. 2016. Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata. doi:10.1111/ijd.12769 PubMed
- [33] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [34] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
- [35] Kumpol Aiempanakit et al.. J Med Assoc Thai. 2016. A Study of Plasma Zinc Levels in Thais with Alopecia Areata. PubMed
- [36] Christine Lux-Battistelli. Dermatol Ther. 2015. Combination therapy with zinc gluconate and PUVA for alopecia areata totalis: an adjunctive but crucial role of zinc supplementation. doi:10.1111/dth.12215 PubMed
- [37] Ladan Dastgheib et al.. Dermatol Res Pract. 2014. Comparison of zn, cu, and fe content in hair and serum in alopecia areata patients with normal group. doi:10.1155/2014/784863 PubMed
- [38] Min Seong Kil et al.. Ann Dermatol. 2013. Analysis of serum zinc and copper concentrations in hair loss. doi:10.5021/ad.2013.25.4.405 PubMed
- [39] Khitam Al-Refu. Int J Trichology. 2013. Hair loss in children: common and uncommon causes; clinical and epidemiological study in jordan. doi:10.4103/0974-7753.130393 PubMed
- [40] Lynn Petukhova et al.. Nature. 2010. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. doi:10.1038/nature09114 PubMed
- [41] Hoon Park et al.. Ann Dermatol. 2009. The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low … doi:10.5021/ad.2009.21.2.142 PubMed
- [42] Yasmeen J Bhat et al.. Indian J Dermatol Venereol Leprol. 2009. Trace element levels in alopecia areata. doi:10.4103/0378-6323.45216 PubMed
- [43] Leonid Benjamin Trost et al.. J Am Acad Dermatol. 2006. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. doi:10.1016/j.jaad.2005.11.1104 PubMed
- [44] F Buzi et al.. J Clin Endocrinol Metab. 2003. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria? doi:10.1210/jc.2002-021495 PubMed
- [45] C Faulkner et al.. Clin Exp Dermatol. 2003. Nonsynchronized segmented heterochromia in black scalp hair. doi:10.1046/j.1365-2230.2003.01257.x PubMed
- [46] R Tazi-Ahnini et al.. Tissue Antigens. 2002. Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia … doi:10.1034/j.1399-0039.2002.600604.x PubMed
- [47] F M Camacho et al.. Pediatr Dermatol. 1999. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. doi:10.1111/j.1525-1470.1999.pdele65.x PubMed
- [48] T Bächer et al.. Dtsch Med Wochenschr. 1997. [The Cronkhite-Canada Syndrome. A rare differential diagnosis of generalized gastrointestinal polyposis]. doi:10.1055/s-2008-1047673 PubMed
- [49] M Tasaki et al.. J Dermatol. 1993. Analyses of serum copper and zinc levels and copper/zinc ratios in skin diseases. doi:10.1111/j.1346-8138.1993.tb03823.x PubMed
- [50] G Chodorowska et al.. Ann Univ Mariae Curie Sklodowska Med. 1990. [Study of the zinc content of hair and serum in selected skin diseases]. PubMed
- [51] G Lutz et al.. Z Hautkr. 1990. [Selective changes in lymphocytic differentiation antigens in the peripheral blood of patients with alopecia areata treated with oral zinc]. PubMed
- [52] F B De Waard-van der Spek et al.. Clin Exp Dermatol. 1989. Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. doi:10.1111/j.1365-2230.1989.tb02604.x PubMed
- [53] F Leyh. Z Hautkr. 1987. [Zinc--a new therapeutic principle in dermatology?]. PubMed
- [54] K Brüske et al.. Z Hautkr. 1987. [Zinc and its status in some dermatologic diseases--a statistical assessment]. PubMed
- [55] H Mussalo-Rauhamaa et al.. Acta Derm Venereol. 1986. Element concentrations in serum, erythrocytes, hair and urine of alopecia patients. PubMed
- [56] A Tosti et al.. G Ital Dermatol Venereol. 1986. [Zinc determination in alopecia areata]. PubMed
- [57] E N Timoshkova et al.. Vestn Dermatol Venerol. 1986. [Complex treatment of alopecia with preparations of zinc and copper]. PubMed
- [58] N Sönnichsen et al.. Dermatol Monatsschr. 1984. [Zinc therapy of alopecia areata]. PubMed
- [59] E N Timoshkova. Vestn Dermatol Venerol. 1984. [Zinc and copper metabolism in patients with alopecia areata]. PubMed
- [60] F Wolowa. Z Hautkr. 1982. [Treatment of alopecia areata totalis and maligna with Solvezink (author's transl)]. PubMed
- [61] R D Ead. Br J Dermatol. 1981. Oral zinc sulphate in alopacia areata-a double blind trial. doi:10.1111/j.1365-2133.1981.tb15323.x PubMed
- [62] A A Studnitsyn et al.. Vestn Dermatol Venerol. 1980. [Use of zinc preparations in children with disseminated forms of alopecia areata]. PubMed
- [63] F Wolowa et al.. Z Hautkr. 1980. [Treatment of alopecia areata with zinc sulfate]. PubMed
- [64] B Lindelöf. Z Hautkr. 1979. [Zinc and the hair; a review of the research results published in the latest literature]. PubMed
- [65] F Wolowa et al.. Przegl Dermatol. 1978. [Zinc sulfate in the treatment of alopecia areata]. PubMed
- [66] B Bergman et al.. Odontol Revy. 1970. Morphologic and autoradiographic observations on the effect of zinc deficiency on endochondral growth sites in the white rat. PubMed
- [67] N I TUMASHEVA et al.. Vestn Dermatol Venerol. 1964. CORRELATION OF ANTI-O-STREPTOLYSIN AND ANTIHYALURONIDASE WITH THE COPPER AND ZINC CONTENT IN THE BLOOD OF PATIENTS WITH ALOPECIA AREATA AND … PubMed
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