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フィナステリド 男性型・女性型脱毛症(AGA)

A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。

合計18,623名の参加者を対象とした129件の研究(メタアナリシス16件、RCT 13件を含む)に基づく。129件中106件の研究で肯定的な効果が示されている。

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A

結論

Finasteride has very strong evidence supporting its effectiveness for androgenetic alopecia and is considered a well-established first-line option backed by decades of research.

  • 106 out of 129 studies show positive effects — one of the most studied hair loss interventions
  • 16 meta-analyses and 13 RCTs provide a robust evidence base across 18,623 participants
  • Works by reducing DHT, the hormone primarily responsible for pattern hair loss
  • Topical finasteride formulations are being researched as an alternative to oral use

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None 効果: None None

対象集団: women with androgenetic alopecia (female pattern hair loss)

non-randomized controlled trial n=60 16 weeks Open-label
Clinical Efficacy and Mechanisms of Microneedling Alone or Combined With Drugs in the Treatment of …
Dose: Mild group: microneedling alone (8 weeks); Moderate group: microneedling + 5% minoxidil (12 weeks); vs: Placebo 効果: All groups showed significant decrease in HLSS and increase in hair density post-treatment (p<0.001) p<0.001
randomized controlled trial n=45 16 weeks Open-label
Clinical and Trichoscopic Evaluations of Topical Finasteride 1%, Topical Spironolactone 5%, and Minoxidil 5% in …
Dose: Group A: topical finasteride 1% solution; Group B: topical spironolactone 5% solution; Group C: topi vs: Placebo 効果: Groups A and C showed significant improvement on Sinclair scale and trichoscopic hair density; Group None
Review
Male and female pattern hair loss.
Dose: None vs: Placebo 効果: None None
randomized controlled trial n=45 Open-label
Clinical efficacy of microneedle combined with 5% Minoxidil solution and finasteride in the treatment of …
Dose: Group A: 5% Minoxidil alone; Group B: 5% Minoxidil + Finasteride; Group C: Microneedling + 5% Minoxi vs: Placebo 効果: Hair density and hair shaft diameter increased in all groups; Group C superior to Group A in Norwood p<0.01

Key Statistics

206

研究数

24777

参加者数

Positive

A

グレード

Referenced Papers

Aesthetic plastic surgery 2025 14 件の引用
Drug design, development … 2025 7 件の引用
Anais brasileiros de … 2025 7 件の引用
International journal of … 2025 5 件の引用
Journal of cosmetic … 2025 3 件の引用
European journal of … 2025 3 件の引用
Australian prescriber 2025 2 件の引用
Journal of cutaneous … 2025 2 件の引用
Skin appendage disorders 2025 1 件の引用
Nature reviews. Disease … 2025
Annals of dermatology 2025
International journal of … 2024 39 件の引用
Dermatology (Basel, Switzerland) 2024 14 件の引用
Indian journal of … 2024 14 件の引用
Journal of cosmetic … 2024 11 件の引用
Journal of clinical … 2024 10 件の引用
Facial plastic surgery … 2024 8 件の引用
Photodermatology, photoimmunology & … 2024 8 件の引用
American family physician 2024 8 件の引用
International journal of … 2024 5 件の引用
Drugs 2023 221 件の引用
JAAD international 2023 80 件の引用
Clinical, cosmetic and … 2023 58 件の引用
American journal of … 2023 41 件の引用
Anais brasileiros de … 2023 29 件の引用
Dermatology and therapy 2023 23 件の引用
Journal der Deutschen … 2023 5 件の引用
International journal of … 2023 5 件の引用
Journal of cosmetic … 2023 3 件の引用
BMJ case reports 2023 2 件の引用
International journal of … 2023 1 件の引用
Clinics in plastic … 2023 1 件の引用
The Journal of … 2022 65 件の引用
Faculty reviews 2022 44 件の引用
Dermatologic therapy 2022 41 件の引用
Archivos espanoles de … 2022 9 件の引用
Cureus 2022 3 件の引用
Facial plastic surgery … 2022
Journal of cutaneous … 2021 44 件の引用
Journal of the … 2021 42 件の引用
Expert opinion on … 2020 147 件の引用
Fertility and sterility 2020 94 件の引用
Neurobiology of stress 2020 72 件の引用
General and comparative … 2020 37 件の引用
Dermatologic therapy 2020 34 件の引用
American journal of … 2020 24 件の引用
Facial plastic surgery … 2020 15 件の引用
Dermatologic clinics 2020 15 件の引用
Alternative therapies in … 2020 11 件の引用
Journal of cosmetic … 2019 100 件の引用
Journal of the … 2019 55 件の引用
Assay and drug … 2019 19 件の引用
The aging male … 2019 19 件の引用
International journal of … 2018 129 件の引用
Indian journal of … 2018 79 件の引用
Lasers in medical … 2018 75 件の引用
Expert opinion on … 2018 38 件の引用
Endocrine 2017 442 件の引用
JAMA dermatology 2017 121 件の引用
Current clinical pharmacology 2017 62 件の引用
Actas dermo-sifiliograficas 2017 17 件の引用
Deutsches Arzteblatt international 2016 99 件の引用
The Cochrane database … 2016 18 件の引用
Indian journal of … 2016 8 件の引用
The Medical clinics … 2015 66 件の引用
Seminars in cutaneous … 2015 27 件の引用
Current problems in … 2015 8 件の引用
Der Internist 2015
Lasers in surgery … 2014 243 件の引用
Journal of cutaneous … 2014 168 件の引用
Expert opinion on … 2014 57 件の引用
Current opinion in … 2014 43 件の引用
Journal of drugs … 2014 26 件の引用
Giornale italiano di … 2014 8 件の引用
Indian journal of … 2013 196 件の引用
Dermatologic clinics 2013 78 件の引用
Journal of cosmetic … 2013 62 件の引用
Sexual medicine reviews 2013 58 件の引用
Facial plastic surgery … 2013 16 件の引用
Journal of drugs … 2013 13 件の引用
International journal of … 2013
Skin therapy letter 2012 100 件の引用
Expert opinion on … 2010 264 件の引用
Current opinion in … 2009 54 件の引用
Seminars in cutaneous … 2009 4 件の引用
American family physician 2009
Nihon rinsho. Japanese … 2008 6 件の引用
Endocrinology and metabolism … 2007 33 件の引用
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Revue medicale de … 2004
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American family physician 2003
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Current pharmaceutical design 1999
International journal of … 1999
American family physician 1999
Journal of the … 1999
Journal of cutaneous … 1999
Dermatologic clinics 1998 121 件の引用
Annales de dermatologie … 1997

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

hairloss:
1 mg/day oral

上限量: 5 mg/day (BPH dose)

研究で検討された用量

用量 期間 効果 N
None -- Neutral --
None -- Neutral --
Mild group: microneedling alone (8 weeks); Moderate group: microneedling + 5% minoxidil (12 weeks); 16 weeks Positive 60
Group A: topical finasteride 1% solution; Group B: topical spironolactone 5% solution; Group C: topi 16 weeks Positive 45
None -- Positive --
Group A: 5% Minoxidil alone; Group B: 5% Minoxidil + Finasteride; Group C: Microneedling + 5% Minoxi -- Positive 45
None -- Positive --
various across included studies (2015-2024) -- Positive --

推奨摂取タイミング: Once daily at the same time, with or without food

Safety & Side Effects

報告されている副作用

  • Decreased libido (2-4% of users)
  • Erectile dysfunction (1-3% of users)
  • Decreased ejaculate volume
  • Breast tenderness or gynecomastia (rare)
  • Depression or mood changes (rare, debated)

既知の相互作用

  • No significant drug-drug interactions identified
  • May affect PSA test results (reduces PSA by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

耐容上限摂取量: 5 mg/day (BPH dose)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does フィナステリド help with 男性型・女性型脱毛症(AGA)?
Based on 206 studies with 24,777 participants, there is strong evidence from multiple clinical trials that フィナステリド may support 男性型・女性型脱毛症(AGA) management. Our evidence grade is A (Strong Evidence).
How much フィナステリド should I take for 男性型・女性型脱毛症(AGA)?
Studies have used various dosages. A commonly studied range is 1 mg/day oral. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of フィナステリド?
Reported side effects may include Decreased libido (2-4% of users), Erectile dysfunction (1-3% of users), Decreased ejaculate volume, Breast tenderness or gynecomastia (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for フィナステリド and 男性型・女性型脱毛症(AGA)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 206 peer-reviewed studies with 24,777 total participants. The overall direction of effect is positive.

References

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