デュタステリド：男性型・女性型脱毛症（AGA）

Q: Does デュタステリド help with 男性型・女性型脱毛症（AGA）?

Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that デュタステリド may support 男性型・女性型脱毛症（AGA） management. Our evidence grade is A (Strong Evidence).

Q: How much デュタステリド should I take for 男性型・女性型脱毛症（AGA）?

Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of デュタステリド?

Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for デュタステリド and 男性型・女性型脱毛症（AGA）?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

合計12,060名の参加者を対象とした43件の研究（メタアナリシス7件、RCT 1件を含む）に基づく。43件中34件の研究で肯定的な効果が示されている。

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結論

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

34 out of 43 studies show positive effects across 12,060 participants
Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review

Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.

Dose: None vs: None Outcome: None 効果: None None

対象集団: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind

Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …

Dose: 0.2 mg dutasteride daily vs: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline 効果: 21.53 vs 5.96 hair count increase 0.0072

対象集団: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind

Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.

Dose: 3 sessions of dutasteride microinfusion (monthly) vs: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment 効果: None None

対象集団: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label

Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …

Dose: 4 monthly sessions of SPi + iontophoresis vs: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … 効果: None <0.001 (density, diam, pull)

対象集団: 10 males + 10 postmenopausal females with resistant AGA

Review

Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.

Dose: Dutasteride (oral, various doses) vs: Placebo 効果: None None

Review

Male and female pattern hair loss.

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

19921

参加者数

↑

Positive

グレード

Referenced Papers

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From … Other

International journal of … 2026 3 件の引用

Oral finasteride use and sexual adverse events: signal detection from disproportionality analyses of data from the United States Food and … Other

The Journal of … 2026 1 件の引用

Injectable Therapy for Androgenetic Alopecia: A Systematic Review. Other

Dermatologic surgery : … 2026

Scalp Microinfusion with Dutasteride Using the MMP® Technique for Male Androgenetic Alopecia: A 12-Month Real-World Observational Case Series. Other

Skin appendage disorders 2026

Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments. Review

American journal of … 2026

Characterization and Management of Androgenetic Alopecia in Transgender and Gender-Diverse Individuals: A Narrative Review. Review

Dermatology and therapy 2026

An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment. Review

Expert opinion on … 2025 10 件の引用

Nutritional deficiencies after sleeve gastrectomy and Roux-en-Y gastric bypass at 10 years: secondary analysis of the SLEEVEPASS randomized clinical trial. RCT

The British journal … 2025 10 件の引用

Epidemiological landscape of androgenetic alopecia in the US: An All of Us cross-sectional study. Other

PloS one 2025 8 件の引用

Topical dutasteride for androgenic alopecia: current state and prospects. Review

Therapeutic delivery 2025 4 件の引用

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 件の引用

Comparative study between fractional CO2 laser alone versus fractional CO2 laser combined with topical dutasteride in treatment of male androgenic … Other

Lasers in medical … 2025 3 件の引用

Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review. Review

Expert opinion on … 2025 3 件の引用

Hair regeneration in androgenetic alopecia using secretome of adipose-derived stem cells (ADSC) and minoxidil: a comparative study of three groups. Other

Archives of dermatological … 2025 3 件の引用

Enhanced hair regrowth with five monthly sessions of minoxidil-dutasteride-copper peptides tattooing for androgenetic alopecia assessed by artificial intelligence and blinded … Other

JAAD international 2025 3 件の引用

Finasteride Use: Evaluation of Depression and Suicide Risk. Other

Journal of cosmetic … 2025 3 件の引用

Efficacy and safety of twice- or thrice-weekly dutasteride versus daily finasteride in men with androgenetic alopecia: A randomized, investigator-blinded, active-controlled, … Other

JAAD international 2025 3 件の引用

Development of Ethosomes for the Topical Treatment of Androgenic Alopecia: Ethanol Effect on Dutasteride Targeting to the Hair Follicles. Other

Pharmaceutics 2025 3 件の引用

Male and female pattern hair loss. Review

Australian prescriber 2025 2 件の引用

A Canadian Consensus on Androgenetic Alopecia: Approach and Management. Other

Journal of cutaneous … 2025 2 件の引用

Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques. Other

Frontiers in bioinformatics 2025 2 件の引用

Treatment of androgenetic alopecia with low-dose oral minoxidil monotherapy compared with combination therapy with dutasteride or finasteride. Other

Journal of the … 2025 2 件の引用

Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical … Meta-Analysis

Journal of cosmetic … 2025 2 件の引用

Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters. Other

Clinical and experimental … 2025 2 件の引用

Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase III … Other

Annals of dermatology 2025 2 件の引用

Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration. Other

International journal of … 2025 2 件の引用

Paradoxical Nonscarring Alopecia Following Mesotherapy with Dutasteride: A Case Series. Other

International journal of … 2025 1 件の引用

Estrogen hormone therapy stabilizes lateral hairline in transfeminine patients: Implications for facial feminization surgery. Other

Journal of plastic, … 2025 1 件の引用

Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®. Other

Skin appendage disorders 2025 1 件の引用

Frontal Fibrosing Alopecia in Men: A Review of the Literature. Review

Journal of clinical … 2025 1 件の引用

Enhanced ex vivo skin retention of bicalutamide using a nano-in-micro composite: Drug-loaded lipid vesicles in a dissolving microarray patch. Other

European journal of … 2025 1 件の引用

Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic Alopecia: A Pilot Study. Other

Dermatology and therapy 2025 1 件の引用

No increased risk of mood disorders in male androgenetic alopecia patients treated with dutasteride and finasteride: A retrospective cohort database … Other

Journal of the … 2025 1 件の引用

Updates in Treatment for Androgenetic Alopecia. Review

Annals of dermatology 2025

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction. Other

Foods (Basel, Switzerland) 2025

Monthly versus quarterly dutasteride mesotherapy for male androgenetic alopecia: A randomized trial. Other

Journal of the … 2025

Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over-the-Counter Products for Male Androgenetic Alopecia: A Network Meta-Analysis Study. Meta-Analysis

Journal of cosmetic … 2025

A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical … Other

Cureus 2025

Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle Papilla Cells. Other

Molecules (Basel, Switzerland) 2025

Effectiveness and Safety of Intralesional Dutasteride in Patients With Androgenic Alopecia: A Systematic Review and Meta-Analysis. Meta-Analysis

Journal of cosmetic … 2025

Similar Risk of Sexual Dysfunction in Androgenetic Alopecia Patients Treated With Dutasteride vs. Finasteride: A Retrospective Cohort Database Study. Other

International journal of … 2025

The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Review

Biomedicines 2024 17 件の引用

Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review. Review

Dermatology (Basel, Switzerland) 2024 14 件の引用

Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies. Review

Journal of clinical … 2024 11 件の引用

Management of androgenic alopecia: a systematic review of the literature. Systematic Review

Journal of cosmetic … 2024 11 件の引用

Association of 5α-Reductase Inhibitors with Depression and Suicide: A Mini Systematic Review and Meta-analysis. Meta-Analysis

European urology focus 2024 10 件の引用

Medical Treatment for Androgenetic Alopecia. Other

Facial plastic surgery … 2024 8 件の引用

The impact of monotherapies for male androgenetic alopecia: A network meta-analysis study. Meta-Analysis

Journal of cosmetic … 2024 8 件の引用

Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia. Review

Expert opinion on … 2024 8 件の引用

Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure … Other

Environmental health : … 2024 7 件の引用

Efficacy and safety of low-dose oral minoxidil in the management of androgenetic alopecia. Review

Expert opinion on … 2024 7 件の引用

The relative effect of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta-analysis study. Meta-Analysis

Journal of cosmetic … 2024 7 件の引用

Sexual dysfunction with 5-alpha-reductase inhibitor therapy for androgenetic alopecia: A global propensity score matched retrospective cohort study. Other

Journal of the … 2024 7 件の引用

Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment. Other

Pharmaceutics 2024 7 件の引用

Development and Evaluation of Dutasteride Nanoemulgel for the Topical Delivery against Androgenic Alopecia. Other

Pharmaceutical nanotechnology 2024 5 件の引用

Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic … Other

Dermatology reports 2024 4 件の引用

Comparative analysis of low-dose oral minoxidil with spironolactone versus finasteride or dutasteride in female androgenetic alopecia management. Other

Archives of dermatological … 2024 4 件の引用

Long-term efficacy and safety of dutasteride 0.5 mg in Korean men with androgenetic alopecia: 5-year data demonstrating clinical improvement with … Other

The Journal of … 2024 4 件の引用

Outcomes of androgenetic alopecia treated with dutasteride mesotherapy: A case series. Case Report

JAAD case reports 2024 4 件の引用

"Effectiveness of minimally invasive injectable modalities in the management of androgenetic alopecia among adults-A systematic review". Systematic Review

Journal of cosmetic … 2024 3 件の引用

Nutrition Challenges and Opportunities When Shifting to Plant-Based Diets. Review

Nestle Nutrition Institute … 2024

What's New in Therapy for Male Androgenetic Alopecia? Other

American journal of … 2023 41 件の引用

Androgenetic alopecia in transgender and gender diverse populations: A review of therapeutics. Review

Journal of the … 2023 24 件の引用

Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review. Review

Dermatology and therapy 2023 23 件の引用

Comparing Current Therapeutic Modalities of Androgenic Alopecia: A Literature Review of Clinical Trials. Review

Cureus 2023 17 件の引用

Evaluating 5 alpha reductase inhibitors for the treatment of male androgenic alopecia. Other

Expert opinion on … 2023 11 件の引用

Evaluation of the therapeutic effects of AGA drugs by measuring finasteride, dutasteride, and dihydrotestosterone in hair. Other

Clinica chimica acta; … 2023 7 件の引用

Hair regrowth in endocrine therapy alopecia with dutasteride treatment in woman with estrogen positive breast cancer. Case Report

JAAD case reports 2023 7 件の引用

Evaluation of hair regrowth after minoxidil and dutasteride tattooing in men with androgenetic alopecia. Other

JAAD international 2023 6 件の引用

Mesotherapy with dutasteride for androgenetic alopecia: a concise review of the literature. Review

European journal of … 2023 5 件の引用

Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia. Other

Medicina (Kaunas, Lithuania) 2023 2 件の引用

Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects. Other

Dermatologic surgery : … 2023 2 件の引用

Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia. Review

The Journal of … 2022 83 件の引用

Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis. Meta-Analysis

JAMA dermatology 2022 69 件の引用

Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract. Other

Plants (Basel, Switzerland) 2022 47 件の引用

Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment … Meta-Analysis

The Journal of … 2022 40 件の引用

Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide. Other

JAMA network open 2022 32 件の引用

Mesotherapy With Dutasteride for Androgenetic Alopecia: A Retrospective Study in Real Clinical Practice. Other

Journal of drugs … 2022 23 件の引用

Nanostructured Drug Delivery Systems for Targeting 5-α-Reductase Inhibitors to the Hair Follicle. Review

Pharmaceutics 2022 23 件の引用

Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart … Other

Annals of dermatology 2022 19 件の引用

Frontal edema due to mesotherapy for androgenetic alopecia: A case series. Other

Dermatologic therapy 2022 14 件の引用

Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis. Systematic Review

Frontiers in medicine 2022 14 件の引用

Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study. RCT

Journal of the … 2022 11 件の引用

Bioengineered polyester nanoparticles for the synergistic treatment of androgenic alopecia via the suppression of 5α-reductase and knockdown of androgen receptor. Other

Frontiers in bioengineering … 2022 6 件の引用

Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and … Other

Scientific reports 2022 6 件の引用

Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis? Review

Biomedicines 2022 5 件の引用

A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body … RCT

The journal of … 2021 16 件の引用

An evaluation of the federal adverse events reporting system data on adverse effects of 5-alpha reductase inhibitors. Other

World journal of … 2021 15 件の引用

5α-Reductase inhibitors in men aged 50 years or older with androgenetic alopecia: A retrospective study. Other

Journal of the … 2021 5 件の引用

Post-finasteride syndrome: a surmountable challenge for clinicians. Review

Fertility and sterility 2020 94 件の引用

Post-finasteride syndrome: An emerging clinical problem. Other

Neurobiology of stress 2020 72 件の引用

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date. Review

Drug design, development … 2020 66 件の引用

5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety. Review

Dermatologic therapy 2020 60 件の引用

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm. Review

The world journal … 2020 51 件の引用

Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates. Review

General and comparative … 2020 37 件の引用

Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review. Review

Skin appendage disorders 2020 35 件の引用

Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: A descriptive monocentric study. Other

Dermatologic therapy 2020 15 件の引用

Physiology and Medical Treatments for Alopecia. Review

Facial plastic surgery … 2020 15 件の引用

In Vitro Performance of Dutasteride-Nanostructured Lipid Carriers Coated with Lauric Acid-Chitosan Oligomer for Dermal Delivery. Other

Pharmaceutics 2020 14 件の引用

Herbal Medicines For Treatment of Androgenic Alopecia. Review

Alternative therapies in … 2020 11 件の引用

Association Between 5-Alpha Reductase Inhibitor Use and The Risk of Depression: A Meta-Analysis. Meta-Analysis

Urology journal 2020 7 件の引用

Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019-2020: A Cross-Sectional Study. Other

Skin appendage disorders 2020 6 件の引用

Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use. Case Report

Yonsei medical journal 2020 4 件の引用

RF-Mesotherapy With Dutasteride: A Future Alternative Treatment for Androgenetic Alopecia. Other

Actas dermo-sifiliograficas 2020 4 件の引用

Impact of dutasteride on spermatogenesis and oxidative status in rats. Other

Archivos espanoles de … 2020 1 件の引用

Androgens in women: Androgen-mediated skin disease and patient evaluation. Review

Journal of the … 2019 95 件の引用

Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. Meta-Analysis

Acta dermato-venereologica 2019 63 件の引用

The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Systematic Review

Clinical interventions in … 2019 57 件の引用

Androgens in women: Hormone-modulating therapies for skin disease. Review

Journal of the … 2019 55 件の引用

Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors. Review

Sexual medicine reviews 2019 26 件の引用

Post-finasteride syndrome - does it really exist? Review

The aging male … 2019 19 件の引用

Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors. Review

Assay and drug … 2019 19 件の引用

In Vitro and In Vivo Assessment of Metabolic Drug Interaction Potential of Dutasteride with Ketoconazole. Other

Pharmaceutics 2019 7 件の引用

An investigation of vitamin and mineral supplement recommendation among first-trimester pregnancies. Other

Journal of perinatal … 2019 5 件の引用

Methods of treatment patients with androgenetic alopecia based on reference of Department of Dermatology in Cracow. Other

Polski merkuriusz lekarski … 2019 4 件の引用

Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia. Other

PloS one 2019 3 件の引用

Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men - short version. Other

Journal of the … 2018 248 件の引用

Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis. Meta-Analysis

Journal of the … 2018 80 件の引用

Guidelines for the diagnosis and treatment of male-pattern and female-pattern hair loss, 2017 version. Other

The Journal of … 2018 69 件の引用

Androgenetic alopecia; drug safety and therapeutic strategies. Review

Expert opinion on … 2018 38 件の引用

Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia. RCT

The Journal of … 2018 14 件の引用

Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2017: A Cross-Sectional Study. Other

Actas dermo-sifiliograficas 2018 9 件の引用

Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled … RCT

Indian journal of … 2017 71 件の引用

Dutasteride in Androgenetic Alopecia: An Update. Review

Current clinical pharmacology 2017 62 件の引用

Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review. Review

Dermatology online journal 2017 49 件の引用

Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia. Other

International journal of … 2017 45 件の引用

Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. Review

Advances in experimental … 2017 45 件の引用

New Treatments for Hair Loss. Review

Actas dermo-sifiliograficas 2017 17 件の引用

Change in Prostate Specific Antigen Concentration in Men with Prostate Specific Antigen Less than 2.5 ng/ml Taking Low Dose Finasteride … Other

The Journal of … 2017 4 件の引用

[What is the value of low-energie lasers in the treatment of androgenetic alopecia ?]. Review

Revue medicale de … 2017

Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia. Other

The Journal of … 2016 54 件の引用

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. Other

Annals of dermatology 2016 27 件の引用

A new label-free screen for steroid 5α-reductase inhibitors using LC-MS. Other

Steroids 2016 20 件の引用

Interventions for female pattern hair loss. Meta-Analysis

The Cochrane database … 2016 18 件の引用

Atypical post-finasteride syndrome: A pharmacological riddle. Case Report

Indian journal of … 2016 8 件の引用

Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know? Review

Reviews in endocrine … 2015 111 件の引用

Female pattern hair loss. Review

Current problems in … 2015 8 件の引用

A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride … RCT

Journal of the … 2014 160 件の引用

The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit-risk assessment of finasteride and dutasteride. Meta-Analysis

The Journal of … 2014 87 件の引用

Emerging treatments in alopecia. Review

Expert opinion on … 2014 57 件の引用

Effect of dutasteride 0.5 mg/d in men with androgenetic alopecia recalcitrant to finasteride. Other

International journal of … 2014 52 件の引用

The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia. Other

Indian journal of … 2014 48 件の引用

5α-Reductase inhibitors in androgenetic alopecia. Review

Current opinion in … 2014 43 件の引用

Pattern hair loss in men: diagnosis and medical treatment. Review

Dermatologic clinics 2013 78 件の引用

Hair loss and herbs for treatment. Review

Journal of cosmetic … 2013 62 件の引用

Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review. Review

Sexual medicine reviews 2013 58 件の引用

Nonsurgical therapy for hair loss. Review

Facial plastic surgery … 2013 16 件の引用

Role of 5α-reductase inhibitors in androgen-stimulated skin disorders. Review

Journal of drugs … 2013 13 件の引用

Hair restoration approaches for early onset male androgenetic alopecia. Case Report

Journal of cosmetic … 2013

Female pattern alopecia: current perspectives. Review

International journal of … 2013

Promising therapies for treating and/or preventing androgenic alopecia. Review

Skin therapy letter 2012 100 件の引用

Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: … RCT

JAMA 2012

Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. Other

ISRN dermatology 2011

Male androgenetic alopecia. Review

Expert opinion on … 2010 264 件の引用

Androgens and hair loss. Review

Current opinion in … 2009 54 件の引用

Hair loss in women. Review

Seminars in cutaneous … 2009 4 件の引用

A review of hormonal therapy for female pattern (androgenic) alopecia. Review

Dermatology online journal 2008

Effective treatment of female androgenic alopecia with dutasteride. Case Report

Journal of drugs … 2005

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

hairloss:: 0.5 mg/day (off-label)

上限量： 0.5 mg/day

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	--
0.2 mg dutasteride daily	24 weeks	Positive	139
3 sessions of dutasteride microinfusion (monthly)	12 weeks	Positive	8
4 monthly sessions of SPi + iontophoresis	8 weeks	Positive	20
Dutasteride (oral, various doses)	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： Once daily at the same time, with or without food; prescription required

Safety & Side Effects

報告されている副作用

⚠ Decreased libido (more common than finasteride)
⚠ Erectile dysfunction
⚠ Ejaculation disorders
⚠ Gynecomastia (breast tissue growth)
⚠ Very long half-life (~5 weeks) means slow side effect resolution

既知の相互作用

● CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
● May affect PSA levels (reduces by ~50%)
● Contraindicated in pregnancy (Category X teratogen)

耐容上限摂取量： 0.5 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does デュタステリド help with 男性型・女性型脱毛症（AGA）?

Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that デュタステリド may support 男性型・女性型脱毛症（AGA） management. Our evidence grade is A (Strong Evidence).

How much デュタステリド should I take for 男性型・女性型脱毛症（AGA）?

Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of デュタステリド?

Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for デュタステリド and 男性型・女性型脱毛症（AGA）?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分：男性型・女性型脱毛症（AGA）

ミノキシジル A フィナステリド A PRP療法 A オメガ3脂肪酸 A マイクロニードリング A 低出力レーザー治療 A

総合評価

合計12,060名の参加者を対象とした43件の研究（メタアナリシス7件、RCT 1件を含む）に基づく。43件中34件の研究で肯定的な効果が示されている。

Evidence Strength92%

High confidence

研究の内訳

RCT (7)Meta (13)Other (79)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：男性型・女性型脱毛症（AGA）

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デュタステリド ： 男性型・女性型脱毛症（AGA）

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： 男性型・女性型脱毛症（AGA）

デュタステリド：男性型・女性型脱毛症（AGA）

に関する他の成分：男性型・女性型脱毛症（AGA）