锌用于雄激素性脱发

基于29项研究（1项荟萃分析、3项RCT），共49,138名参与者。各研究结果不一。

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结论

Research on zinc for androgenetic alopecia is mixed — while zinc is important for hair follicle health, supplementation alone has not been clearly shown to improve pattern hair loss.

Mixed results across 29 studies, including a meta-analysis showing inconsistent findings
Some studies find lower zinc in people with pattern hair loss, others do not
Zinc is usually studied as part of multi-ingredient formulas, making its individual contribution unclear
Supplementation may only help if a zinc deficiency is confirmed

Key Study Findings

animal study

Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights …

Dose: zinc and/or selenium supplementation; doses not specified in abstract vs: Placebo 效果: None None

Review

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.

Dose: None vs: Placebo 效果: None None

review

[Nutrition in improving sleep quality and fighting insomnia].

Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral vs: Placebo 效果: None None

cross-sectional study

Zinc Status in Kurdish Adults With Hair Loss.

Dose: None vs: Placebo 效果: None None

systematic_review

Micronutrients and Androgenetic Alopecia: A Systematic Review.

Dose: variable across included studies vs: Placebo 效果: vitamin B, D, iron, zinc deficiencies associated with increased AGA risk; supplementation showed pot None

in vitro study

Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 …

Dose: not specified vs: Placebo 效果: melanin production 130.18 ± 9.13% of control; NO secretion 1.43 ± 0.05 µM p > 0.05 (vs theophylline, no

Key Statistics

研究数量

49138

受试者

↔

Mixed

等级

Referenced Papers

Protective mechanisms of zinc and/or selenium supplementation against BPA-induced male and offspring reproductive toxicity: Insights from multiomics analysis. Other

Environment international 2026

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. Review

Current medicinal chemistry 2025 5 次引用

Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications. Review

Biomedicine & pharmacotherapy … 2025 4 次引用

[Nutrition in improving sleep quality and fighting insomnia]. Review

Nutricion hospitalaria 2025

Micronutrients and Androgenetic Alopecia: A Systematic Review. Systematic Review

Molecular nutrition & … 2024 7 次引用

Zinc Status in Kurdish Adults With Hair Loss. Other

Cureus 2024 1 次引用

A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch. Other

Bioactive materials 2023 108 次引用

Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. Other

Theranostics 2023 65 次引用

Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 … Other

Plants (Basel, Switzerland) 2023 14 次引用

Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … Other

Italian journal of … 2023 3 次引用

Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study. Other

European journal of … 2022 34 次引用

Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, … RCT

Journal of cosmetic … 2022 11 次引用

The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. Review

Human nutrition & … 2022 9 次引用

Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. Other

JAAD international 2022 6 次引用

Association between serum zinc levels and androgenetic alopecia: a systematic review and meta-analysis. Meta-Analysis

Journal of cosmetic … 2022 5 次引用

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. Other

Dermatology reports 2022 4 次引用

A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. RCT

Italian journal of … 2022 2 次引用

Erosive pustular dermatosis of the scalp: causes and treatments. Review

International journal of … 2021 23 次引用

Vulvar Fordyce adenitis: A cohort of 45 women. Other

Annales de dermatologie … 2021 4 次引用

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy's Effectiveness. Other

Diagnostics (Basel, Switzerland) 2020 13 次引用

Dietary zinc supplement militates against ketamine-induced behaviours by age-dependent modulation of oxidative stress and acetylcholinesterase activity in mice. Other

Pharmacological reports : … 2020 7 次引用

A Matched Case-Control Study of Zinc Levels in Androgenetic Alopecia and Alopecia Areata: Is There a Need to Do Routine … Other

Skinmed 2020

Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee. Meta-Analysis

The Journal of … 2019 101 次引用

Serum biotin and zinc in male androgenetic alopecia. Other

Journal of cosmetic … 2019 15 次引用

Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study. Other

Indian journal of … 2018 26 次引用

Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. Other

International journal of … 2017 43 次引用

Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: … Other

Journal of research … 2017 12 次引用

Low plasma zinc levels in androgenetic alopecia. Other

Indian journal of … 2017 10 次引用

Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Other

International journal of … 2016 28 次引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 次引用

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss. Other

Journal of ethnopharmacology 2015 37 次引用

BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia. Other

Journal of trace … 2014 62 次引用

Evidence for supplemental treatments in androgenetic alopecia. Other

Journal of drugs … 2014 26 次引用

Analysis of serum zinc and copper concentrations in hair loss. Other

Annals of dermatology 2013 114 次引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 次引用

[Effectiveness of the treatment plan for androgenetic alopecia]. Other

Georgian medical news 2007

The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. Review

Journal of the … 2006 255 次引用

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. Other

International journal of … 2002 53 次引用

Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. Other

Clinical and experimental … 1989 140 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 8-11 mg/day
hairloss:: 15-30 mg/day

上限： 40 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
zinc and/or selenium supplementation; doses not specified in abstract	--	Positive	--
None	--	Positive	--
tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral	--	Positive	--
None	--	Neutral	--
variable across included studies	--	Mixed	--
not specified	--	Positive	--
Daily tablet (L-cystine, L-methionine, liposomal glutathione, zinc, copper, iron, selenium, ubidecar	24 weeks	Positive	20
Topical lotion containing zinc and arginine (concentration not specified)	23 weeks	Positive	40

最佳服用时间： With meals to minimize stomach upset; separate from iron and calcium by 2 hours

Safety & Side Effects

已报告的副作用

⚠ Nausea and vomiting (especially on an empty stomach)
⚠ Metallic taste in the mouth
⚠ Copper depletion with chronic high-dose use
⚠ Headache and diarrhea

已知相互作用

● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)

可耐受最高摄入量： 40 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 锌 help with 雄激素性脱发?

Based on 33 studies with 49,138 participants, there is strong evidence from multiple clinical trials that 锌 may support 雄激素性脱发 management. Our evidence grade is A (Strong Evidence).

How much 锌 should I take for 雄激素性脱发?

Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 锌?

Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use, Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 锌 and 雄激素性脱发?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 33 peer-reviewed studies with 49,138 total participants. The overall direction of effect is mixed.

Related Evidence

其他成分用于雄激素性脱发

米诺地尔（Minoxidil） A 非那雄胺（Finasteride） A PRP 疗法 A 度他雄胺（Dutasteride） A Omega-3 脂肪酸 A 微针疗法 A

锌用于其他健康状况

斑秃 F 休止期脱发 F

快速结论

基于29项研究（1项荟萃分析、3项RCT），共49,138名参与者。各研究结果不一。

Evidence Strength92%

High confidence

研究分析

RCT (2)Meta (2)Other (29)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于雄激素性脱发

了解更多

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