锌用于休止期脱发

F 效果研究表明，该用途可能不太有效。

基于29项研究（3项RCT），共30,246名参与者。各研究结果不一。

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结论

Moderate evidence suggests that zinc deficiency may contribute to telogen effluvium, and supplementation may help if levels are low — but routine zinc supplementation for hair shedding is not clearly supported.

Lower zinc levels are frequently found in telogen effluvium patients
Some RCTs show benefits from zinc-containing supplement combinations
Difficult to isolate zinc's specific effect from multi-ingredient formulas
Testing zinc levels and supplementing only if deficient is a reasonable approach

Key Study Findings

Prospective Open-Label Interventional Study n=343 4 weeks Open-label

Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium.

Dose: Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month vs: Placebo 效果: Significant improvements in all hair parameters at T1 and T2 (P < 0.001) p<0.001

Retrospective Cross-Sectional Study n=23975

Hair Loss and Zinc Deficiency: A Cross-Sectional Study.

Dose: None vs: Placebo 效果: Median zinc 96 µg/dL (hair loss) vs 99 µg/dL (control); statistically significant but clinically min p<0.001

cross-sectional study

Zinc Status in Kurdish Adults With Hair Loss.

Dose: None vs: Placebo 效果: None None

Case-Control Study n=100

Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia.

Dose: None vs: Placebo 效果: None 0.05

case-control study n=180

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …

Dose: not applicable vs: Placebo 效果: None None

Case-control n=100

Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value …

Dose: None vs: Placebo 效果: None None

Key Statistics

研究数量

30246

受试者

↔

Mixed

等级

Referenced Papers

Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium. Other

International journal of … 2025

Hair Loss and Zinc Deficiency: A Cross-Sectional Study. Other

Healthcare (Basel, Switzerland) 2025

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … Other

Journal of cosmetic … 2024 7 次引用

Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value of dietary supplements. a case … Other

Archives of dermatological … 2024 5 次引用

Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. Other

JPMA. The Journal … 2024 2 次引用

Cost-effectiveness analysis of laboratory monitoring in newly diagnosed telogen effluvium patients. Other

Archives of dermatological … 2024 1 次引用

Zinc Status in Kurdish Adults With Hair Loss. Other

Cureus 2024 1 次引用

"Shedding" low yield testing for telogen effluvium: A cross-sectional study of 16,381 laboratory results from newly diagnosed patients. Other

Journal of the … 2023 5 次引用

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. Other

Dermatology practical & … 2023 4 次引用

Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) … Other

Italian journal of … 2023 4 次引用

Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … Other

Italian journal of … 2023 3 次引用

Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. Other

Journal of cosmetic … 2022 22 次引用

The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. Review

Human nutrition & … 2022 9 次引用

Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. Other

JAAD international 2022 6 次引用

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. Other

Dermatology reports 2022 4 次引用

A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. RCT

Italian journal of … 2022 2 次引用

Laboratory Testing in Telogen Effluvium. Other

Journal of drugs … 2021 3 次引用

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Other

Clinical, cosmetic and … 2018 16 次引用

Assessment of Heavy Metal and Trace Element Levels in Patients with Telogen Effluvium. Other

Indian journal of … 2018 14 次引用

Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. Other

International journal of … 2017 43 次引用

Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. Other

Journal of drugs … 2016 56 次引用

Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Other

International journal of … 2016 28 次引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 次引用

Possible Relationship between Chronic Telogen Effluvium and Changes in Lead, Cadmium, Zinc, and Iron Total Blood Levels in Females: A … Other

International journal of … 2015 18 次引用

Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. Other

Journal of cutaneous … 2014 10 次引用

Analysis of serum zinc and copper concentrations in hair loss. Other

Annals of dermatology 2013 114 次引用

Hair loss in children: common and uncommon causes; clinical and epidemiological study in jordan. Other

International journal of … 2013 37 次引用

Oral zinc therapy for zinc deficiency-related telogen effluvium. Case Report

Dermatologic therapy 2012 31 次引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 次引用

The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. Review

Journal of the … 2006 255 次引用

Dermatologic signs in patients with eating disorders. Review

American journal of … 2005 140 次引用

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. Other

International journal of … 2002 53 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 8-11 mg/day
hairloss:: 15-30 mg/day

上限： 40 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month	4 weeks	Positive	343
None	--	Neutral	23975
None	--	Neutral	--
None	--	Negative	100
not applicable	--	Mixed	180
None	--	Mixed	100
None	--	Mixed	--
4 tablets daily (arginine, l-cystine, zinc, vitamin B6)	12 weeks	Positive	20

最佳服用时间： With meals to minimize stomach upset; separate from iron and calcium by 2 hours

Safety & Side Effects

已报告的副作用

⚠ Nausea and vomiting (especially on an empty stomach)
⚠ Metallic taste in the mouth
⚠ Copper depletion with chronic high-dose use
⚠ Headache and diarrhea

已知相互作用

● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)

可耐受最高摄入量： 40 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 锌 help with 休止期脱发?

Based on 32 studies with 30,246 participants, there is insufficient evidence at this time that 锌 may support 休止期脱发 management. Our evidence grade is F (Evidence Against).

How much 锌 should I take for 休止期脱发?

Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 锌?

Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use, Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 锌 and 休止期脱发?

We rate the evidence as Grade F (Evidence Against). This rating is based on 32 peer-reviewed studies with 30,246 total participants. The overall direction of effect is mixed.

其他成分用于休止期脱发

米诺地尔（Minoxidil） A 黑种草油 A Viviscal A 铁 B 角蛋白（Keratin） B Omega-3 脂肪酸 B

锌用于其他健康状况

雄激素性脱发 A 斑秃 F

快速结论

基于29项研究（3项RCT），共30,246名参与者。各研究结果不一。

Evidence Strength10%

Low confidence

研究分析

RCT (1)Meta (0)Other (31)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于休止期脱发

了解更多

References

[1] Eva María Arias et al.. Int J Trichology. 2025. Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium. doi:10.4103/ijt.ijt_70_24 PubMed
[2] Ori Liran et al.. Healthcare (Basel). 2025. Hair Loss and Zinc Deficiency: A Cross-Sectional Study. doi:10.3390/healthcare13222965 PubMed
[3] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
[4] Nermeen Ibrahim Bedair et al.. Arch Dermatol Res. 2024. Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value of dietary supplements. a case … doi:10.1007/s00403-024-03004-1 PubMed
[5] Shayan Zufishan et al.. J Pak Med Assoc. 2024. Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. doi:10.47391/JPMA-DUHS-S10 PubMed
[6] Rhiannon C Miller et al.. Arch Dermatol Res. 2024. Cost-effectiveness analysis of laboratory monitoring in newly diagnosed telogen effluvium patients. doi:10.1007/s00403-024-02948-8 PubMed
[7] Hivi Mahmoud et al.. Cureus. 2024. Zinc Status in Kurdish Adults With Hair Loss. doi:10.7759/cureus.67264 PubMed
[8] Rhiannon C Miller et al.. J Am Acad Dermatol. 2023. "Shedding" low yield testing for telogen effluvium: A cross-sectional study of 16,381 laboratory results from newly diagnosed patients. doi:10.1016/j.jaad.2023.05.045 PubMed
[9] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
[10] Michela Starace et al.. Ital J Dermatol Venerol. 2023. Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) … doi:10.23736/S2784-8671.23.07576-X PubMed
[11] Michela Starace et al.. Ital J Dermatol Venerol. 2023. Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … doi:10.23736/S2784-8671.22.07416-3 PubMed
[12] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
[13] Noor Altooq et al.. Hum Nutr Metab. 2022. The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. doi:10.1016/j.hnm.2022.200141 PubMed
[14] Elizabeth J Klein et al.. JAAD Int. 2022. Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. doi:10.1016/j.jdin.2022.08.013 PubMed
[15] Mohammed Al Abadie et al.. Dermatol Reports. 2022. Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. doi:10.4081/dr.2022.9512 PubMed
[16] Alfredo Rossi et al.. Ital J Dermatol Venerol. 2022. A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. doi:10.23736/S2784-8671.21.06915-7 PubMed
[17] Efe Kakpovbia et al.. J Drugs Dermatol. 2021. Laboratory Testing in Telogen Effluvium. doi:10.36849/JDD.5771 PubMed
[18] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
[19] Ibrahim Halil Yavuz et al.. Indian J Dermatol. 2018. Assessment of Heavy Metal and Trace Element Levels in Patients with Telogen Effluvium. doi:10.4103/ijd.IJD_610_17 PubMed
[20] Dinesh Gowda et al.. Int J Trichology. 2017. Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. doi:10.4103/ijt.ijt_48_16 PubMed
[21] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
[22] Tee Wei Siah et al.. Int J Trichology. 2016. Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. doi:10.4103/0974-7753.188033 PubMed
[23] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
[24] Abeer M Abdel Aziz et al.. Int J Trichology. 2015. Possible Relationship between Chronic Telogen Effluvium and Changes in Lead, Cadmium, Zinc, and Iron Total Blood Levels in Females: A … doi:10.4103/0974-7753.167465 PubMed
[25] Thamer Mubki. J Cutan Med Surg. 2014. Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. doi:10.2310/7750.2014.14008 PubMed
[26] Min Seong Kil et al.. Ann Dermatol. 2013. Analysis of serum zinc and copper concentrations in hair loss. doi:10.5021/ad.2013.25.4.405 PubMed
[27] Khitam Al-Refu. Int J Trichology. 2013. Hair loss in children: common and uncommon causes; clinical and epidemiological study in jordan. doi:10.4103/0974-7753.130393 PubMed
[28] Tadashi Karashima et al.. Dermatol Ther. 2012. Oral zinc therapy for zinc deficiency-related telogen effluvium. doi:10.1111/j.1529-8019.2012.01443.x PubMed
[29] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
[30] Leonid Benjamin Trost et al.. J Am Acad Dermatol. 2006. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. doi:10.1016/j.jaad.2005.11.1104 PubMed
[31] Renata Strumia. Am J Clin Dermatol. 2005. Dermatologic signs in patients with eating disorders. doi:10.2165/00128071-200506030-00003 PubMed
[32] C Piérard-Franchimont et al.. Int J Cosmet Sci. 2002. Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. doi:10.1046/j.1467-2494.2002.00145.x PubMed

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锌 用于 休止期脱发