角蛋白（Keratin） 用于 休止期脱发
B 证据 至少一项随机试验支持这一结论，结果基本一致。基于5项研究（1项RCT），共60名参与者。多数研究显示无效果或负面效果。
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B
结论
Research does not support keratin supplementation as helpful for telogen effluvium — the limited evidence available suggests it is unlikely to meaningfully reduce this type of hair shedding.
- Majority of studies show negative or no effects for keratin in telogen effluvium
- Very small participant pool (60 people) limits the reliability of findings
- Telogen effluvium has different underlying mechanisms than age-related thinning, where keratin shows more promise
- Other approaches may be more effective for addressing telogen effluvium specifically
Key Study Findings
Case Reports
n=1
Open-label
Plica Neuropathica (Polonica) Secondary to Diffuse Alopecia: A Case Report and Literature Review.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: 62-year-old female with diffuse alopecia and plica neuropathica
Systematic Review
Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled …
Dose: Various regenerative methods
vs: Standard treatment or placebo
Outcome: Dermatologic disease improvement
效果: None
None
研究人群: Patients with specific dermatologic diseases
Review
The Role of One-Carbon Metabolism in Healthy Brain Aging.
Dose: None
vs: None
Outcome: folate status
效果: None
None
研究人群: None
Review
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Dose: None
vs: None
Outcome: Hair regrowth
效果: None
None
研究人群: Alopecia patients
Other
Reply to "Vitamin D status in scarring and nonscarring alopecia".
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
11
研究数量
61
受试者
↑
Positive
B
等级
Referenced Papers
Plica Neuropathica (Polonica) Secondary to Diffuse Alopecia: A Case Report and Literature Review.
Case Report
Cureus
2025
Scientific reports
2025
Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled clinical trials.
Systematic Review
Stem cell research …
2024
2 次引用
Nutrients
2023
9 次引用
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.
Review
Regenerative therapy
2022
96 次引用
Journal of the …
2022
6 次引用
Journal of cosmetic …
2021
44 次引用
Experimental dermatology
2020
10 次引用
Clinical, cosmetic and …
2019
7 次引用
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 次引用
Medical archives (Sarajevo, …
2018
16 次引用
Journal of photochemistry …
2018
16 次引用
Experimental dermatology
2003
35 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- hairloss:
- 500 mg/day
上限： Not established
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | 1 |
| Various regenerative methods | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| not applicable (genetic association study) | -- | Negative | 60 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
最佳服用时间： With meals for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Generally well tolerated
- ⚠ Mild gastrointestinal discomfort in some individuals
- ⚠ Rare allergic reactions
已知相互作用
- ● No significant drug interactions established
- ● May interact with protein absorption in individuals with digestive disorders
可耐受最高摄入量： Not established
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 角蛋白（Keratin） help with 休止期脱发?
Based on 11 studies with 61 participants, there is moderate evidence from clinical studies that 角蛋白（Keratin） may support 休止期脱发 management. Our evidence grade is B (Good Evidence).
How much 角蛋白（Keratin） should I take for 休止期脱发?
Studies have used various dosages. A commonly studied range is 500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 角蛋白（Keratin）?
Reported side effects may include Generally well tolerated, Mild gastrointestinal discomfort in some individuals, Rare allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 角蛋白（Keratin） and 休止期脱发?
We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 61 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 休止期脱发
角蛋白（Keratin） 用于其他健康状况
References
- [1] Alondra Saray Polanco-Llanes et al.. Cureus. 2025. Plica Neuropathica (Polonica) Secondary to Diffuse Alopecia: A Case Report and Literature Review. doi:10.7759/cureus.93402 PubMed
- [2] Stefanie Klingenstein et al.. Sci Rep. 2025. Ex vivo detection of SARS CoV 2 spike protein in human hair follicles and potential link to telogen effluvium. doi:10.1038/s41598-025-28909-3 PubMed
- [3] Alireza Jafarzadeh et al.. Stem Cell Res Ther. 2024. Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled clinical trials. doi:10.1186/s13287-024-03800-6 PubMed
- [4] Sapna Virdi et al.. Nutrients. 2023. The Role of One-Carbon Metabolism in Healthy Brain Aging. doi:10.3390/nu15183891 PubMed
- [5] Yusuke Shimizu et al.. Regen Ther. 2022. Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature. doi:10.1016/j.reth.2022.10.005 PubMed
- [6] Shawn Afvari et al.. J Am Acad Dermatol. 2022. Reply to "Vitamin D status in scarring and nonscarring alopecia". doi:10.1016/j.jaad.2022.04.055 PubMed
- [7] Kriteeka Saini et al.. J Cosmet Dermatol. 2021. Role of vitamin D in hair loss: A short review. doi:10.1111/jocd.14421 PubMed
- [8] Ralf Paus et al.. Exp Dermatol. 2020. Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? doi:10.1111/exd.14156 PubMed
- [9] Iman Seleit et al.. Clin Cosmet Investig Dermatol. 2019. Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. doi:10.2147/CCID.S227232 PubMed
- [10] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
- [11] Erkin Pekmezci et al.. Med Arch. 2018. Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia. doi:10.5455/medarh.2018.72.136-140 PubMed
- [12] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [13] Petra Clara Arck et al.. Exp Dermatol. 2003. Topical minoxidil counteracts stress-induced hair growth inhibition in mice. doi:10.1034/j.1600-0625.2003.00028.x PubMed
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