Folato para Perda Capilar por Deficiência Nutricional
F Efeito A pesquisa indica que é pouco provável que seja eficaz para esta utilização.Baseado em 11 estudos com 4,429 participantes no total. Os resultados são variados entre os estudos.
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F
Conclusão
The evidence linking folate supplementation to hair regrowth is limited and mixed — folate deficiency may contribute to hair loss in some cases, but supplementation is not well-supported as a general hair loss remedy.
- Results are mixed across 11 studies, with no clear consensus on folate's role in hair loss
- No randomized controlled trials have specifically tested folate supplementation for hair regrowth
- Folate deficiency may be more relevant when caused by medications (e.g., methotrexate) rather than diet
- Blood testing for folate levels may help determine if supplementation is appropriate
Key Study Findings
In Vitro
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells.
Dose: None
vs: Untreated hepatic cells
Outcome: Cytotoxicity via apoptosis and ER stress
Efeito: None
None
População: Primary human hepatocytes and HepG2 cells
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
Efeito: None
None
Review
Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Review of pharmacogenomics of THC and CBD
In Vitro
2 weeks
Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows.
Dose: 10.2% d
vs: None
Outcome: glycemic control
Efeito: None
None
População: Cows
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
Efeito: r=0.417 (HGB and AHR in females)
p=0.008
retrospective cohort study
n=3028
Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …
Dose: standard replacement doses
vs: Placebo
Efeito: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2%
None
Key Statistics
11
Estudos
4166
Participantes
↔
Mixed
F
Nota
Referenced Papers
Nutrients
2025
2 citações
Archives of toxicology
2025
1 citações
Genes
2025
1 citações
Journal of dairy …
2023
8 citações
Dermatology practical & …
2023
4 citações
Journal of cosmetic …
2022
22 citações
Medical cannabis and …
2018
158 citações
American journal of …
2017
104 citações
Journal of drugs …
2016
56 citações
Clinical and experimental …
2009
34 citações
Dermatologic clinics
1993
38 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 400 mcg DFE/day
Limite superior: 1,000 mcg/day (synthetic folic acid)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 10.2% d | 2 weeks | Mixed | -- |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
Melhor horário: With meals for better absorption
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
Interações Conhecidas
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
Ingestão máxima tolerável: 1,000 mcg/day (synthetic folic acid)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Folato help with Perda Capilar por Deficiência Nutricional?
Based on 11 studies with 4,166 participants, there is insufficient evidence at this time that Folato may support Perda Capilar por Deficiência Nutricional management. Our evidence grade is F (Evidence Against).
How much Folato should I take for Perda Capilar por Deficiência Nutricional?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folato?
Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folato and Perda Capilar por Deficiência Nutricional?
We rate the evidence as Grade F (Evidence Against). This rating is based on 11 peer-reviewed studies with 4,166 total participants. The overall direction of effect is mixed.
Related Evidence
Outros ingredientes para Perda Capilar por Deficiência Nutricional
Folato para outras condições
References
- [1] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [2] Yuxi Li et al.. Arch Toxicol. 2025. 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells. doi:10.1007/s00204-025-04001-7 PubMed
- [3] Małgorzata Kalak et al.. Genes (Basel). 2025. Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. doi:10.3390/genes16121487 PubMed
- [4] F Addo et al.. J Dairy Sci. 2023. Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows. doi:10.3168/jds.2023-23222 PubMed
- [5] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
- [6] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
- [7] Arno Hazekamp. Med Cannabis Cannabinoids. 2018. The Trouble with CBD Oil. doi:10.1159/000489287 PubMed
- [8] Jordan M Thompson et al.. Am J Clin Dermatol. 2017. The Role of Micronutrients in Alopecia Areata: A Review. doi:10.1007/s40257-017-0285-x PubMed
- [9] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
- [10] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
- [11] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.