Folat untuk Kerontokan Rambut Akibat Defisiensi Nutrisi
F Efek Penelitian menunjukkan bahwa ini kemungkinan tidak efektif untuk penggunaan ini.Berdasarkan 11 studi dengan 4,429 peserta secara total. Hasil bervariasi di antara studi-studi tersebut.
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F
Kesimpulan
The evidence linking folate supplementation to hair regrowth is limited and mixed — folate deficiency may contribute to hair loss in some cases, but supplementation is not well-supported as a general hair loss remedy.
- Results are mixed across 11 studies, with no clear consensus on folate's role in hair loss
- No randomized controlled trials have specifically tested folate supplementation for hair regrowth
- Folate deficiency may be more relevant when caused by medications (e.g., methotrexate) rather than diet
- Blood testing for folate levels may help determine if supplementation is appropriate
Key Study Findings
In Vitro
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells.
Dose: None
vs: Untreated hepatic cells
Outcome: Cytotoxicity via apoptosis and ER stress
Efek: None
None
Populasi: Primary human hepatocytes and HepG2 cells
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
Efek: None
None
Review
Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Review of pharmacogenomics of THC and CBD
In Vitro
2 weeks
Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows.
Dose: 10.2% d
vs: None
Outcome: glycemic control
Efek: None
None
Populasi: Cows
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
Efek: r=0.417 (HGB and AHR in females)
p=0.008
retrospective cohort study
n=3028
Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …
Dose: standard replacement doses
vs: Placebo
Efek: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2%
None
Key Statistics
11
Studi
4166
Peserta
↔
Mixed
F
Peringkat
Referenced Papers
Nutrients
2025
2 sitasi
Archives of toxicology
2025
1 sitasi
Genes
2025
1 sitasi
Journal of dairy …
2023
8 sitasi
Dermatology practical & …
2023
4 sitasi
Journal of cosmetic …
2022
22 sitasi
Medical cannabis and …
2018
158 sitasi
American journal of …
2017
104 sitasi
Journal of drugs …
2016
56 sitasi
Clinical and experimental …
2009
34 sitasi
Dermatologic clinics
1993
38 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 400 mcg DFE/day
Batas atas: 1,000 mcg/day (synthetic folic acid)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 10.2% d | 2 weeks | Mixed | -- |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
Waktu terbaik diminum: With meals for better absorption
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
Interaksi yang Diketahui
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
Asupan atas yang dapat ditoleransi: 1,000 mcg/day (synthetic folic acid)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Folat help with Kerontokan Rambut Akibat Defisiensi Nutrisi?
Based on 11 studies with 4,166 participants, there is insufficient evidence at this time that Folat may support Kerontokan Rambut Akibat Defisiensi Nutrisi management. Our evidence grade is F (Evidence Against).
How much Folat should I take for Kerontokan Rambut Akibat Defisiensi Nutrisi?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folat?
Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folat and Kerontokan Rambut Akibat Defisiensi Nutrisi?
We rate the evidence as Grade F (Evidence Against). This rating is based on 11 peer-reviewed studies with 4,166 total participants. The overall direction of effect is mixed.
Related Evidence
Bahan lain untuk Kerontokan Rambut Akibat Defisiensi Nutrisi
Folat untuk kondisi lain
References
- [1] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [2] Yuxi Li et al.. Arch Toxicol. 2025. 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells. doi:10.1007/s00204-025-04001-7 PubMed
- [3] Małgorzata Kalak et al.. Genes (Basel). 2025. Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. doi:10.3390/genes16121487 PubMed
- [4] F Addo et al.. J Dairy Sci. 2023. Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows. doi:10.3168/jds.2023-23222 PubMed
- [5] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
- [6] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
- [7] Arno Hazekamp. Med Cannabis Cannabinoids. 2018. The Trouble with CBD Oil. doi:10.1159/000489287 PubMed
- [8] Jordan M Thompson et al.. Am J Clin Dermatol. 2017. The Role of Micronutrients in Alopecia Areata: A Review. doi:10.1007/s40257-017-0285-x PubMed
- [9] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
- [10] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
- [11] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed
Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.