葉酸 ： 栄養不足による脱毛症
F 効果 研究によると、この用途への効果は期待しにくい可能性があります。合計4,429名の参加者を対象とした11件の研究に基づく。研究間で結果にばらつきが見られる。
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F
結論
The evidence linking folate supplementation to hair regrowth is limited and mixed — folate deficiency may contribute to hair loss in some cases, but supplementation is not well-supported as a general hair loss remedy.
- Results are mixed across 11 studies, with no clear consensus on folate's role in hair loss
- No randomized controlled trials have specifically tested folate supplementation for hair regrowth
- Folate deficiency may be more relevant when caused by medications (e.g., methotrexate) rather than diet
- Blood testing for folate levels may help determine if supplementation is appropriate
Key Study Findings
In Vitro
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells.
Dose: None
vs: Untreated hepatic cells
Outcome: Cytotoxicity via apoptosis and ER stress
効果: None
None
対象集団: Primary human hepatocytes and HepG2 cells
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
効果: None
None
Review
Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of pharmacogenomics of THC and CBD
In Vitro
2 weeks
Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows.
Dose: 10.2% d
vs: None
Outcome: glycemic control
効果: None
None
対象集団: Cows
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
効果: r=0.417 (HGB and AHR in females)
p=0.008
retrospective cohort study
n=3028
Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …
Dose: standard replacement doses
vs: Placebo
効果: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2%
None
Key Statistics
11
研究数
4166
参加者数
↔
Mixed
F
グレード
Referenced Papers
Nutrients
2025
2 件の引用
Archives of toxicology
2025
1 件の引用
Genes
2025
1 件の引用
Journal of dairy …
2023
8 件の引用
Dermatology practical & …
2023
4 件の引用
Journal of cosmetic …
2022
22 件の引用
Medical cannabis and …
2018
158 件の引用
American journal of …
2017
104 件の引用
Journal of drugs …
2016
56 件の引用
Clinical and experimental …
2009
34 件の引用
Dermatologic clinics
1993
38 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 400 mcg DFE/day
上限量： 1,000 mcg/day (synthetic folic acid)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 10.2% d | 2 weeks | Mixed | -- |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
推奨摂取タイミング： With meals for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
既知の相互作用
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
耐容上限摂取量： 1,000 mcg/day (synthetic folic acid)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does 葉酸 help with 栄養不足による脱毛症?
Based on 11 studies with 4,166 participants, there is insufficient evidence at this time that 葉酸 may support 栄養不足による脱毛症 management. Our evidence grade is F (Evidence Against).
How much 葉酸 should I take for 栄養不足による脱毛症?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 葉酸?
Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 葉酸 and 栄養不足による脱毛症?
We rate the evidence as Grade F (Evidence Against). This rating is based on 11 peer-reviewed studies with 4,166 total participants. The overall direction of effect is mixed.
Related Evidence
References
- [1] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [2] Yuxi Li et al.. Arch Toxicol. 2025. 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells. doi:10.1007/s00204-025-04001-7 PubMed
- [3] Małgorzata Kalak et al.. Genes (Basel). 2025. Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. doi:10.3390/genes16121487 PubMed
- [4] F Addo et al.. J Dairy Sci. 2023. Quality and safety of hemp meal as a protein supplement for nonlactating dairy cows. doi:10.3168/jds.2023-23222 PubMed
- [5] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
- [6] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
- [7] Arno Hazekamp. Med Cannabis Cannabinoids. 2018. The Trouble with CBD Oil. doi:10.1159/000489287 PubMed
- [8] Jordan M Thompson et al.. Am J Clin Dermatol. 2017. The Role of Micronutrients in Alopecia Areata: A Review. doi:10.1007/s40257-017-0285-x PubMed
- [9] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
- [10] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
- [11] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed
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