葉酸：休止期脱毛症

Q: Does 葉酸 help with 休止期脱毛症?

Based on 10 studies with 7,126 participants, there is moderate evidence from clinical studies that 葉酸 may support 休止期脱毛症 management. Our evidence grade is B (Good Evidence).

Q: How much 葉酸 should I take for 休止期脱毛症?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of 葉酸?

Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for 葉酸 and 休止期脱毛症?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 7,126 total participants. The overall direction of effect is mixed.

B エビデンス少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。

合計4,166名の参加者を対象とした6件の研究に基づく。研究間で結果にばらつきが見られる。

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結論

There is limited evidence connecting folate to telogen effluvium — while low folate levels have been observed in some patients, research does not yet support folate supplementation as a reliable approach for this condition.

Mixed results across 6 studies — no consistent pattern linking folate levels to telogen effluvium
All studies are observational; no randomized controlled trials exist for this specific use
Folate is one of many micronutrients that may play a supporting role in hair health
A comprehensive nutritional assessment may be more useful than supplementing folate alone

Key Study Findings

Retrospective cohort n=2851

Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.

Dose: None vs: Placebo 効果: Ferritin low in 46.5% of patients; iron deficiency in 29.5% p<0.05

Review

Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.

Dose: None vs: Placebo 効果: None None

Cross-Sectional Study n=108

Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with …

Dose: None vs: Placebo 効果: None 0.05

Case-control n=973

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …

Dose: None vs: Placebo 効果: r=0.417 (HGB and AHR in females) p=0.008

retrospective cohort study n=3028

Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …

Dose: standard replacement doses vs: Placebo 効果: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2% None

randomized controlled trial 26 weeks

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.

Dose: recommended daily intake amounts; taken orally for 180 days vs: Placebo 効果: Group 1 trichoscopy improvement 11.09% vs Group 2 7.76% after 180 days (significant for Group 1 only P<0.05 for clinical parameters

Key Statistics

研究数

7126

参加者数

↔

Mixed

グレード

Referenced Papers

Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. Other

Journal of cosmetic … 2025 4 件の引用

Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. Review

Nutrients 2025 2 件の引用

Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin … Other

Northern clinics of … 2024 1 件の引用

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. Other

Dermatology practical & … 2023 4 件の引用

Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. Other

Journal of cosmetic … 2022 22 件の引用

Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. Other

Journal of photochemistry … 2018 16 件の引用

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Other

Clinical, cosmetic and … 2018 16 件の引用

Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. Other

Journal of drugs … 2016 56 件の引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 件の引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 件の引用

Management of hair loss in women. Review

Dermatologic clinics 1993 38 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 400 mcg DFE/day

上限量： 1,000 mcg/day (synthetic folic acid)

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	2851
None	--	Mixed	--
None	--	Mixed	108
None	--	Positive	973
standard replacement doses	--	Neutral	3028
recommended daily intake amounts; taken orally for 180 days	26 weeks	Positive	--
psychiatric and dermatological management	--	Neutral	1
None	--	Negative	--

推奨摂取タイミング： With meals for better absorption

Safety & Side Effects

報告されている副作用

⚠ Generally well tolerated
⚠ May mask vitamin B12 deficiency symptoms at high doses
⚠ Rare: abdominal cramps, insomnia

既知の相互作用

● Methotrexate (folate antagonist; consult physician)
● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
● Sulfasalazine (reduces folate absorption)

耐容上限摂取量： 1,000 mcg/day (synthetic folic acid)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does 葉酸 help with 休止期脱毛症?

Based on 10 studies with 7,126 participants, there is moderate evidence from clinical studies that 葉酸 may support 休止期脱毛症 management. Our evidence grade is B (Good Evidence).

How much 葉酸 should I take for 休止期脱毛症?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 葉酸?

Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 葉酸 and 休止期脱毛症?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 7,126 total participants. The overall direction of effect is mixed.

に関する他の成分：休止期脱毛症

ミノキシジル A ブラックシードオイル A ビビスカル A 鉄 B ケラチン B オメガ3脂肪酸 B

葉酸他の症状・状態について

栄養不足による脱毛症 F

総合評価

合計4,166名の参加者を対象とした6件の研究に基づく。研究間で結果にばらつきが見られる。

Evidence Strength72%

High confidence

研究の内訳

RCT (0)Meta (0)Other (10)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：休止期脱毛症

詳しく見る

References

[1] Ömer Karakoyun et al.. J Cosmet Dermatol. 2025. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. doi:10.1111/jocd.70037 PubMed
[2] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
[3] Leyla Bilik et al.. North Clin Istanb. 2024. Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin … doi:10.14744/nci.2023.33269 PubMed
[4] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
[5] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
[6] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
[7] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
[8] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
[9] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
[10] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
[11] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed

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葉酸 ： 休止期脱毛症