Folato para Telogen Effluvium
B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.Baseado em 6 estudos com 4,166 participantes no total. Os resultados são variados entre os estudos.
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B
Conclusão
There is limited evidence connecting folate to telogen effluvium — while low folate levels have been observed in some patients, research does not yet support folate supplementation as a reliable approach for this condition.
- Mixed results across 6 studies — no consistent pattern linking folate levels to telogen effluvium
- All studies are observational; no randomized controlled trials exist for this specific use
- Folate is one of many micronutrients that may play a supporting role in hair health
- A comprehensive nutritional assessment may be more useful than supplementing folate alone
Key Study Findings
Retrospective cohort
n=2851
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Dose: None
vs: Placebo
Efeito: Ferritin low in 46.5% of patients; iron deficiency in 29.5%
p<0.05
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
Efeito: None
None
Cross-Sectional Study
n=108
Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with …
Dose: None
vs: Placebo
Efeito: None
0.05
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
Efeito: r=0.417 (HGB and AHR in females)
p=0.008
retrospective cohort study
n=3028
Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …
Dose: standard replacement doses
vs: Placebo
Efeito: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2%
None
randomized controlled trial
26 weeks
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Dose: recommended daily intake amounts; taken orally for 180 days
vs: Placebo
Efeito: Group 1 trichoscopy improvement 11.09% vs Group 2 7.76% after 180 days (significant for Group 1 only
P<0.05 for clinical parameters
Key Statistics
10
Estudos
7126
Participantes
↔
Mixed
B
Nota
Referenced Papers
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Other
Journal of cosmetic …
2025
4 citações
Nutrients
2025
2 citações
Northern clinics of …
2024
1 citações
Dermatology practical & …
2023
4 citações
Journal of cosmetic …
2022
22 citações
Journal of photochemistry …
2018
16 citações
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 citações
Journal of drugs …
2016
56 citações
Acta dermatovenerologica Croatica …
2016
6 citações
Clinical and experimental …
2009
34 citações
Dermatologic clinics
1993
38 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 400 mcg DFE/day
Limite superior: 1,000 mcg/day (synthetic folic acid)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Neutral | 2851 |
| None | -- | Mixed | -- |
| None | -- | Mixed | 108 |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| psychiatric and dermatological management | -- | Neutral | 1 |
| None | -- | Negative | -- |
Melhor horário: With meals for better absorption
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
Interações Conhecidas
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
Ingestão máxima tolerável: 1,000 mcg/day (synthetic folic acid)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Folato help with Telogen Effluvium?
Based on 10 studies with 7,126 participants, there is moderate evidence from clinical studies that Folato may support Telogen Effluvium management. Our evidence grade is B (Good Evidence).
How much Folato should I take for Telogen Effluvium?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folato?
Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folato and Telogen Effluvium?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 7,126 total participants. The overall direction of effect is mixed.
Related Evidence
Outros ingredientes para Telogen Effluvium
Folato para outras condições
References
- [1] Ömer Karakoyun et al.. J Cosmet Dermatol. 2025. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. doi:10.1111/jocd.70037 PubMed
- [2] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [3] Leyla Bilik et al.. North Clin Istanb. 2024. Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin … doi:10.14744/nci.2023.33269 PubMed
- [4] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
- [5] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
- [6] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [7] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
- [8] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
- [9] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
- [10] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
- [11] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.