スピロノラクトン : 男性型・女性型脱毛症(AGA)
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。合計6,273名の参加者を対象とした25件の研究(メタアナリシス4件、RCT 2件を含む)に基づく。25件中19件の研究で肯定的な効果が示されている。
結論
Spironolactone is well-supported by research as an anti-androgen medication that may help reduce hair loss in androgenetic alopecia, particularly in women, though it requires medical supervision.
- 76% of studies show positive effects, backed by 4 meta-analyses
- Works by blocking androgen hormones that contribute to hair miniaturization
- Particularly studied in women with PCOS-related and female pattern hair loss
- Requires prescription and medical monitoring due to hormonal effects
Key Study Findings
対象集団: women with androgenetic alopecia (female pattern hair loss)
対象集団: Individuals with insomnia
対象集団: Pediatric patients with androgenetic alopecia (multicenter)
対象集団: Patients with androgenetic alopecia
Key Statistics
45
研究数
6472
参加者数
Positive
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- hairloss:
- 100-200 mg/day (prescription)
上限量: 200 mg/day (hair loss indication)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| Spironolactone 100 mg once daily | 24 weeks | Positive | 48 |
| CBD 300 mg + 1 mg each of 8 terpenes | 4 weeks | Positive | 125 |
| None | -- | Positive | 203 |
| None | -- | Positive | 30 |
| various across included studies (2015-2024) | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング: Once or twice daily with food; prescription required
Safety & Side Effects
報告されている副作用
- ⚠ Menstrual irregularities
- ⚠ Breast tenderness
- ⚠ Hyperkalemia (elevated potassium levels)
- ⚠ Dizziness and orthostatic hypotension
- ⚠ Frequent urination
既知の相互作用
- ● ACE inhibitors and ARBs (increased hyperkalemia risk)
- ● Potassium supplements and potassium-sparing diuretics (dangerous hyperkalemia)
- ● NSAIDs (may reduce diuretic effectiveness and increase kidney risk)
- ● Digoxin (spironolactone may increase digoxin levels)
耐容上限摂取量: 200 mg/day (hair loss indication)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does スピロノラクトン help with 男性型・女性型脱毛症(AGA)?
How much スピロノラクトン should I take for 男性型・女性型脱毛症(AGA)?
Are there side effects of スピロノラクトン?
How strong is the evidence for スピロノラクトン and 男性型・女性型脱毛症(AGA)?
Related Evidence
References
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