Skip to main content
HairCited

스피로놀락톤 관련 안드로겐성 탈모증

A 근거 여러 대규모 임상 시험이 일관되게 유의미한 효과를 보여줍니다.

총 6,273명의 참여자를 대상으로 한 25건의 연구(메타분석 4건, RCT 2건)에 근거합니다. 25건 중 19건의 연구에서 긍정적인 효과가 나타났습니다.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'haircited.com'; const params = 'ingredient\u003Dspironolactone\u0026condition\u003Dandrogenetic\u002Dalopecia'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    

Widget powered by . Free, no account required.

A

결론

Spironolactone is well-supported by research as an anti-androgen medication that may help reduce hair loss in androgenetic alopecia, particularly in women, though it requires medical supervision.

  • 76% of studies show positive effects, backed by 4 meta-analyses
  • Works by blocking androgen hormones that contribute to hair miniaturization
  • Particularly studied in women with PCOS-related and female pattern hair loss
  • Requires prescription and medical monitoring due to hormonal effects

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None 효과: None None

대상 집단: women with androgenetic alopecia (female pattern hair loss)

Review
Male and female pattern hair loss.
Dose: None vs: Placebo 효과: None None
RCT n=48 24 weeks Double-blind
Efficacy and safety of oral spironolactone for female pattern hair loss in premenopausal women: a …
Dose: Spironolactone 100 mg once daily vs: Placebo 효과: Terminal hair counts: 9.48 vs 5.32 hairs/cm2; hair diameter: 4.23 vs 2.96 μm; moderate-to-marked imp p=0.063 (terminal hair counts)
Randomized Controlled Trial n=125 4 weeks Double-blind
Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, …
Dose: CBD 300 mg + 1 mg each of 8 terpenes vs: Placebo Outcome: Percentage of time in SWS + REM sleep 효과: 1.3% increase [0.1-2.5%]; up to 48 min/night in su 0.03

대상 집단: Individuals with insomnia

Cohort Study n=203
An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia.
Dose: None vs: None Outcome: Clinical presentation and treatment outcomes in pediatric AGA 효과: None None

대상 집단: Pediatric patients with androgenetic alopecia (multicenter)

Randomized Controlled Trial n=30
A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation …
Dose: None vs: Drug therapy (minoxidil + finasteride/spironolactone) only Outcome: Follicle survival rate, growth rate, hair strength 효과: None None

대상 집단: Patients with androgenetic alopecia

Key Statistics

45

연구

6472

참여자

Positive

A

등급

Referenced Papers

Australian prescriber 2025 2 인용
Journal of cosmetic … 2024 11 인용
JAAD international 2023 80 인용
Clinical, cosmetic and … 2023 58 인용
Alternative therapies in … 2020 11 인용
BMJ case reports 2017 6 인용
The Cochrane database … 2016 18 인용
Current problems in … 2015 8 인용
International journal of … 2013
Seminars in cutaneous … 2009 4 인용
Revue medicale de … 2004
Current pharmaceutical design 1999
Journal of the … 1999
Dermatologic clinics 1998 121 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

hairloss:
100-200 mg/day (prescription)

상한량: 200 mg/day (hair loss indication)

연구에서 사용된 용량

용량 기간 효과 N
None -- Neutral --
None -- Positive --
Spironolactone 100 mg once daily 24 weeks Positive 48
CBD 300 mg + 1 mg each of 8 terpenes 4 weeks Positive 125
None -- Positive 203
None -- Positive 30
various across included studies (2015-2024) -- Positive --
None -- Mixed --

권장 복용 시간: Once or twice daily with food; prescription required

Safety & Side Effects

보고된 부작용

  • Menstrual irregularities
  • Breast tenderness
  • Hyperkalemia (elevated potassium levels)
  • Dizziness and orthostatic hypotension
  • Frequent urination

알려진 상호작용

  • ACE inhibitors and ARBs (increased hyperkalemia risk)
  • Potassium supplements and potassium-sparing diuretics (dangerous hyperkalemia)
  • NSAIDs (may reduce diuretic effectiveness and increase kidney risk)
  • Digoxin (spironolactone may increase digoxin levels)

일일 최대 섭취 허용량: 200 mg/day (hair loss indication)

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 스피로놀락톤 help with 안드로겐성 탈모증?
Based on 45 studies with 6,472 participants, there is strong evidence from multiple clinical trials that 스피로놀락톤 may support 안드로겐성 탈모증 management. Our evidence grade is A (Strong Evidence).
How much 스피로놀락톤 should I take for 안드로겐성 탈모증?
Studies have used various dosages. A commonly studied range is 100-200 mg/day (prescription). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 스피로놀락톤?
Reported side effects may include Menstrual irregularities, Breast tenderness, Hyperkalemia (elevated potassium levels), Dizziness and orthostatic hypotension. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 스피로놀락톤 and 안드로겐성 탈모증?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 45 peer-reviewed studies with 6,472 total participants. The overall direction of effect is positive.

스피로놀락톤 다른 건강 상태에 대한 근거

References

  1. [1] Caitlin A Kearney et al.. Am J Clin Dermatol. 2026. Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments. doi:10.1007/s40257-026-01009-2 PubMed
  2. [2] Jair Alejandro Valdez-Zertuche et al.. Expert Opin Drug Metab Toxicol. 2025. Efficacy, safety and tolerability of drugs for alopecia: a comprehensive review. doi:10.1080/17425255.2025.2461483 PubMed
  3. [3] Ilmari Saarinen et al.. Br J Surg. 2025. Nutritional deficiencies after sleeve gastrectomy and Roux-en-Y gastric bypass at 10 years: secondary analysis of the SLEEVEPASS randomized clinical trial. doi:10.1093/bjs/znaf132 PubMed
  4. [4] Aditya K Gupta et al.. PLoS One. 2025. Epidemiological landscape of androgenetic alopecia in the US: An All of Us cross-sectional study. doi:10.1371/journal.pone.0319040 PubMed
  5. [5] Sarah Schaffer et al.. Cureus. 2025. A Scoping Review of Exosome Delivery Applications in Hair Loss. doi:10.7759/cureus.81152 PubMed
  6. [6] Michael Wang et al.. J Clin Sleep Med. 2025. Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study. doi:10.5664/jcsm.11324 PubMed
  7. [7] Ping Xue et al.. J Cosmet Dermatol. 2025. A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia. doi:10.1111/jocd.16665 PubMed
  8. [8] Pimpakarn Werachattawatchai et al.. Int J Womens Dermatol. 2025. Efficacy and safety of oral spironolactone for female pattern hair loss in premenopausal women: a randomized, double-blind, placebo-controlled, parallel-group pilot … doi:10.1097/JW9.0000000000000227 PubMed
  9. [9] Tyan Shin Lee et al.. J Am Acad Dermatol. 2025. An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia. doi:10.1016/j.jaad.2025.02.002 PubMed
  10. [10] Paola Loli et al.. Endocrine. 2025. Non-classical congenital adrenal hyperplasia: current insights into clinical implications, diagnosis and treatment. doi:10.1007/s12020-025-04341-5 PubMed
  11. [11] Laxmi Iyengar et al.. Aust Prescr. 2025. Male and female pattern hair loss. doi:10.18773/austprescr.2025.020 PubMed
  12. [12] Nghiem H Nguyen et al.. J Plast Reconstr Aesthet Surg. 2025. Estrogen hormone therapy stabilizes lateral hairline in transfeminine patients: Implications for facial feminization surgery. doi:10.1016/j.bjps.2024.07.044 PubMed
  13. [13] Alpana Mohta et al.. Int J Trichology. 2025. Evaluating the Role of the Gabrin Sign in Predicting COVID-19 Severity Among Patients with Androgenic Alopecia. doi:10.4103/ijt.ijt_5_23 PubMed
  14. [14] Barbara Owecka et al.. Biomedicines. 2024. The Hormonal Background of Hair Loss in Non-Scarring Alopecias. doi:10.3390/biomedicines12030513 PubMed
  15. [15] Afsaneh Sadeghzadeh Bazargan et al.. J Cosmet Dermatol. 2024. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral … doi:10.1111/jocd.15979 PubMed
  16. [16] Amanda Rosenthal et al.. J Cosmet Laser Ther. 2024. Management of androgenic alopecia: a systematic review of the literature. doi:10.1080/14764172.2024.2362126 PubMed
  17. [17] S Morteza Seyed Jafari et al.. J Clin Med. 2024. Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies. doi:10.3390/jcm13113052 PubMed
  18. [18] Mengxue He et al.. Mol Nutr Food Res. 2024. Cannabidiol (CBD) Inhibits Foam Cell Formation via Regulating Cholesterol Homeostasis and Lipid Metabolism. doi:10.1002/mnfr.202400154 PubMed
  19. [19] Deesha D Desai et al.. Arch Dermatol Res. 2024. Comparative analysis of low-dose oral minoxidil with spironolactone versus finasteride or dutasteride in female androgenetic alopecia management. doi:10.1007/s00403-024-03361-x PubMed
  20. [20] Ambika Nohria et al.. JAAD Int. 2024. Improving efficacy and maintaining safety in the treatment of alopecia with low-dose oral minoxidil and spironolactone combination therapy: A retrospective … doi:10.1016/j.jdin.2024.07.023 PubMed
  21. [21] Faiz-Ul Hassan et al.. Front Immunol. 2023. Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges. doi:10.3389/fimmu.2023.1285052 PubMed
  22. [22] Sincengile Ntshingila et al.. JAAD Int. 2023. Androgenetic alopecia: An update. doi:10.1016/j.jdin.2023.07.005 PubMed
  23. [23] Michael Kaiser et al.. Clin Cosmet Investig Dermatol. 2023. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs. doi:10.2147/CCID.S385861 PubMed
  24. [24] Chaofan Wang et al.. Clin Cosmet Investig Dermatol. 2023. The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review. doi:10.2147/CCID.S398950 PubMed
  25. [25] Julia L Gao et al.. J Am Acad Dermatol. 2023. Androgenetic alopecia in transgender and gender diverse populations: A review of therapeutics. doi:10.1016/j.jaad.2021.08.067 PubMed
  26. [26] Nathalie Y Ly et al.. J Am Acad Dermatol. 2023. Medical and procedural treatment of androgenetic alopecia - Where are we? doi:10.1016/j.jaad.2023.05.004 PubMed
  27. [27] Majed Aleissa. Cureus. 2023. The Efficacy and Safety of Oral Spironolactone in the Treatment of Female Pattern Hair Loss: A Systematic Review and Meta-Analysis. doi:10.7759/cureus.43559 PubMed
  28. [28] JaBreia F James et al.. J Am Acad Dermatol. 2022. Efficacy and safety profile of oral spironolactone use for androgenic alopecia: A systematic review. doi:10.1016/j.jaad.2021.07.048 PubMed
  29. [29] Xuelei Liang et al.. Front Med (Lausanne). 2022. Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: … doi:10.3389/fmed.2022.905140 PubMed
  30. [30] Pravesh Sharma et al.. PEC Innov. 2022. Primary care provider attitudes, experiences and practices about cannabidiol (CBD) and barriers to patient-provider communication about CBD use: A qualitative … doi:10.1016/j.pecinn.2022.100044 PubMed
  31. [31] Fan Zhang et al.. Clin Cosmet Investig Dermatol. 2022. Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles. doi:10.2147/CCID.S383289 PubMed
  32. [32] Shafik Boyaji et al.. Curr Pain Headache Rep. 2020. The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence. doi:10.1007/s11916-020-0835-4 PubMed
  33. [33] Chapman Wei et al.. J Am Acad Dermatol. 2020. Spironolactone use does not increase the risk of female breast cancer recurrence: A retrospective analysis. doi:10.1016/j.jaad.2020.05.081 PubMed
  34. [34] Solmaz Asnaashari et al.. Altern Ther Health Med. 2020. Herbal Medicines For Treatment of Androgenic Alopecia. PubMed
  35. [35] Enrico Carmina et al.. J Clin Endocrinol Metab. 2019. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee. doi:10.1210/jc.2018-02548 PubMed
  36. [36] Amanda Bienenfeld et al.. J Am Acad Dermatol. 2019. Androgens in women: Androgen-mediated skin disease and patient evaluation. doi:10.1016/j.jaad.2018.08.062 PubMed
  37. [37] Sarah Azarchi et al.. J Am Acad Dermatol. 2019. Androgens in women: Hormone-modulating therapies for skin disease. doi:10.1016/j.jaad.2018.08.061 PubMed
  38. [38] Karolina Kozicka et al.. Pol Merkur Lekarski. 2019. Methods of treatment patients with androgenetic alopecia based on reference of Department of Dermatology in Cracow. PubMed
  39. [39] G Fabbrocini et al.. Int J Womens Dermatol. 2018. Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review. doi:10.1016/j.ijwd.2018.05.001 PubMed
  40. [40] C Pindado-Ortega et al.. Actas Dermosifiliogr (Engl Ed). 2018. Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2017: A Cross-Sectional Study. doi:10.1016/j.ad.2018.02.006 PubMed
  41. [41] Marlene Rodrigues et al.. BMJ Case Rep. 2017. Androgenic alopecia: an entity to consider in adolescence. doi:10.1136/bcr-2017-220679 PubMed
  42. [42] Esther J van Zuuren et al.. Cochrane Database Syst Rev. 2016. Interventions for female pattern hair loss. doi:10.1002/14651858.CD007628.pub4 PubMed
  43. [43] Jay C Vary. Med Clin North Am. 2015. Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis. doi:10.1016/j.mcna.2015.07.003 PubMed
  44. [44] Timothy H Schmidt et al.. J Am Acad Dermatol. 2015. Evidence-based approach to cutaneous hyperandrogenism in women. doi:10.1016/j.jaad.2015.05.026 PubMed
  45. [45] Dimitrios Ioannides et al.. Curr Probl Dermatol. 2015. Female pattern hair loss. doi:10.1159/000369404 PubMed
  46. [46] Rehab Nabil Shamma et al.. Int J Nanomedicine. 2014. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. doi:10.2147/IJN.S73010 PubMed
  47. [47] Lauren L Levy et al.. Int J Womens Health. 2013. Female pattern alopecia: current perspectives. doi:10.2147/IJWH.S49337 PubMed
  48. [48] R Sinclair et al.. Br J Dermatol. 2011. Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. doi:10.1111/j.1365-2133.2011.10630.x PubMed
  49. [49] Deepani Rathnayake et al.. Dermatol Clin. 2010. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss. doi:10.1016/j.det.2010.03.011 PubMed
  50. [50] Andreas D Katsambas et al.. Clin Dermatol. 2010. Hormonal therapy for acne: why not as first line therapy? facts and controversies. doi:10.1016/j.clindermatol.2009.03.006 PubMed
  51. [51] Francisco M Camacho-Martínez. Semin Cutan Med Surg. 2009. Hair loss in women. doi:10.1016/j.sder.2009.01.001 PubMed
  52. [52] Noah Scheinfeld. Dermatol Online J. 2008. A review of hormonal therapy for female pattern (androgenic) alopecia. PubMed
  53. [53] Carlijn Hoedemaker et al.. Australas J Dermatol. 2007. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. doi:10.1111/j.1440-0960.2007.00332.x PubMed
  54. [54] Serge Ahouansou et al.. Eur J Dermatol. 2007. Association of androgenetic alopecia and hypertension. doi:10.1684/ejd.2007.0152 PubMed
  55. [55] V del Marmol et al.. Rev Med Brux. 2004. [Androgenetic alopecia]. PubMed
  56. [56] J McMurray et al.. Eur J Heart Fail. 2001. Practical recommendations for the use of ACE inhibitors, beta-blockers and spironolactone in heart failure: putting guidelines into practice. doi:10.1016/s1388-9842(01)00173-8 PubMed
  57. [57] E Diamanti-Kandarakis. Curr Pharm Des. 1999. Current aspects of antiandrogen therapy in women. PubMed
  58. [58] A Tosti et al.. J Eur Acad Dermatol Venereol. 1999. Management of androgenetic alopecia. PubMed
  59. [59] J Shapiro et al.. Dermatol Clin. 1998. Hair regrowth. Therapeutic agents. doi:10.1016/s0733-8635(05)70017-6 PubMed
  60. [60] D A Adamopoulos et al.. Clin Endocrinol (Oxf). 1997. Beneficial effect of spironolactone on androgenic alopecia. doi:10.1046/j.1365-2265.1997.3761162.x PubMed
  61. [61] G P Redmond et al.. J Am Acad Dermatol. 1990. Treatment of androgenic disorders with dexamethasone: dose-response relationship for suppression of dehydroepiandrosterone sulfate. doi:10.1016/0190-9622(90)70014-9 PubMed
  62. [62] B M Burke et al.. Br J Dermatol. 1985. Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia. doi:10.1111/j.1365-2133.1985.tb02305.x PubMed

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.