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Spironolactone के लिए Androgenetic Alopecia

A संबंधित साक्ष्य कई बड़े नैदानिक परीक्षण लगातार महत्वपूर्ण लाभ दर्शाते हैं।

25 अध्ययनों (4 meta-analyses, 2 RCTs) पर आधारित, में कुल 6,273 प्रतिभागियों के साथ। 19/25 अध्ययन सकारात्मक प्रभाव दिखाते हैं।

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A

निष्कर्ष

Spironolactone is well-supported by research as an anti-androgen medication that may help reduce hair loss in androgenetic alopecia, particularly in women, though it requires medical supervision.

  • 76% of studies show positive effects, backed by 4 meta-analyses
  • Works by blocking androgen hormones that contribute to hair miniaturization
  • Particularly studied in women with PCOS-related and female pattern hair loss
  • Requires prescription and medical monitoring due to hormonal effects

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: women with androgenetic alopecia (female pattern hair loss)

Review
Male and female pattern hair loss.
Dose: None बनाम: Placebo प्रभाव: None None
RCT n=48 24 weeks Double-blind
Efficacy and safety of oral spironolactone for female pattern hair loss in premenopausal women: a …
Dose: Spironolactone 100 mg once daily बनाम: Placebo प्रभाव: Terminal hair counts: 9.48 vs 5.32 hairs/cm2; hair diameter: 4.23 vs 2.96 μm; moderate-to-marked imp p=0.063 (terminal hair counts)
Randomized Controlled Trial n=125 4 weeks Double-blind
Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, …
Dose: CBD 300 mg + 1 mg each of 8 terpenes बनाम: Placebo Outcome: Percentage of time in SWS + REM sleep प्रभाव: 1.3% increase [0.1-2.5%]; up to 48 min/night in su 0.03

जनसंख्या: Individuals with insomnia

Cohort Study n=203
An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia.
Dose: None बनाम: None Outcome: Clinical presentation and treatment outcomes in pediatric AGA प्रभाव: None None

जनसंख्या: Pediatric patients with androgenetic alopecia (multicenter)

Randomized Controlled Trial n=30
A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation …
Dose: None बनाम: Drug therapy (minoxidil + finasteride/spironolactone) only Outcome: Follicle survival rate, growth rate, hair strength प्रभाव: None None

जनसंख्या: Patients with androgenetic alopecia

Key Statistics

45

अध्ययन

6472

प्रतिभागी

Positive

A

ग्रेड

Referenced Papers

Expert opinion on … 2025 11 उद्धरण
Australian prescriber 2025 2 उद्धरण
Biomedicines 2024 17 उद्धरण
Journal of cosmetic … 2024 11 उद्धरण
JAAD international 2023 80 उद्धरण
Clinical, cosmetic and … 2023 58 उद्धरण
Journal of the … 2023 20 उद्धरण
Alternative therapies in … 2020 11 उद्धरण
Journal of the … 2019 95 उद्धरण
Journal of the … 2019 55 उद्धरण
International journal of … 2018 129 उद्धरण
BMJ case reports 2017 6 उद्धरण
The Cochrane database … 2016 18 उद्धरण
The Medical clinics … 2015 66 उद्धरण
Journal of the … 2015 50 उद्धरण
Current problems in … 2015 8 उद्धरण
International journal of … 2013
The British journal … 2011 96 उद्धरण
Seminars in cutaneous … 2009 4 उद्धरण
The Australasian journal … 2007 32 उद्धरण
Revue medicale de … 2004
Current pharmaceutical design 1999
Journal of the … 1999
Dermatologic clinics 1998 121 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

hairloss:
100-200 mg/day (prescription)

अधिकतम सीमा: 200 mg/day (hair loss indication)

अनुसंधान में अध्ययन की गई खुराकें

खुराक अवधि प्रभाव N
None -- Neutral --
None -- Positive --
Spironolactone 100 mg once daily 24 weeks Positive 48
CBD 300 mg + 1 mg each of 8 terpenes 4 weeks Positive 125
None -- Positive 203
None -- Positive 30
various across included studies (2015-2024) -- Positive --
None -- Mixed --

सेवन का सर्वोत्तम समय: Once or twice daily with food; prescription required

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

  • Menstrual irregularities
  • Breast tenderness
  • Hyperkalemia (elevated potassium levels)
  • Dizziness and orthostatic hypotension
  • Frequent urination

ज्ञात अंतःक्रियाएँ

  • ACE inhibitors and ARBs (increased hyperkalemia risk)
  • Potassium supplements and potassium-sparing diuretics (dangerous hyperkalemia)
  • NSAIDs (may reduce diuretic effectiveness and increase kidney risk)
  • Digoxin (spironolactone may increase digoxin levels)

सहनीय अधिकतम सेवन: 200 mg/day (hair loss indication)

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Spironolactone help with Androgenetic Alopecia?
Based on 45 studies with 6,472 participants, there is strong evidence from multiple clinical trials that Spironolactone may support Androgenetic Alopecia management. Our evidence grade is A (Strong Evidence).
How much Spironolactone should I take for Androgenetic Alopecia?
Studies have used various dosages. A commonly studied range is 100-200 mg/day (prescription). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Spironolactone?
Reported side effects may include Menstrual irregularities, Breast tenderness, Hyperkalemia (elevated potassium levels), Dizziness and orthostatic hypotension. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Spironolactone and Androgenetic Alopecia?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 45 peer-reviewed studies with 6,472 total participants. The overall direction of effect is positive.

इसके लिए अन्य सामग्री Androgenetic Alopecia

Spironolactone अन्य स्वास्थ्य स्थितियों के लिए

References

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FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।