螺内酯(Spironolactone) 用于 雄激素性脱发
A 证据 多项大型临床试验一致显示出显著的益处。基于25项研究(4项荟萃分析、2项RCT),共6,273名参与者。19/25项研究显示积极效果。
结论
Spironolactone is well-supported by research as an anti-androgen medication that may help reduce hair loss in androgenetic alopecia, particularly in women, though it requires medical supervision.
- 76% of studies show positive effects, backed by 4 meta-analyses
- Works by blocking androgen hormones that contribute to hair miniaturization
- Particularly studied in women with PCOS-related and female pattern hair loss
- Requires prescription and medical monitoring due to hormonal effects
Key Study Findings
研究人群: women with androgenetic alopecia (female pattern hair loss)
研究人群: Individuals with insomnia
研究人群: Pediatric patients with androgenetic alopecia (multicenter)
研究人群: Patients with androgenetic alopecia
Key Statistics
45
研究数量
6472
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- hairloss:
- 100-200 mg/day (prescription)
上限: 200 mg/day (hair loss indication)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| Spironolactone 100 mg once daily | 24 weeks | Positive | 48 |
| CBD 300 mg + 1 mg each of 8 terpenes | 4 weeks | Positive | 125 |
| None | -- | Positive | 203 |
| None | -- | Positive | 30 |
| various across included studies (2015-2024) | -- | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间: Once or twice daily with food; prescription required
Safety & Side Effects
已报告的副作用
- ⚠ Menstrual irregularities
- ⚠ Breast tenderness
- ⚠ Hyperkalemia (elevated potassium levels)
- ⚠ Dizziness and orthostatic hypotension
- ⚠ Frequent urination
已知相互作用
- ● ACE inhibitors and ARBs (increased hyperkalemia risk)
- ● Potassium supplements and potassium-sparing diuretics (dangerous hyperkalemia)
- ● NSAIDs (may reduce diuretic effectiveness and increase kidney risk)
- ● Digoxin (spironolactone may increase digoxin levels)
可耐受最高摄入量: 200 mg/day (hair loss indication)
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 螺内酯(Spironolactone) help with 雄激素性脱发?
How much 螺内酯(Spironolactone) should I take for 雄激素性脱发?
Are there side effects of 螺内酯(Spironolactone)?
How strong is the evidence for 螺内酯(Spironolactone) and 雄激素性脱发?
Related Evidence
其他成分用于 雄激素性脱发
螺内酯(Spironolactone) 用于其他健康状况
References
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