Масло чёрного тмина для Alopecia Areata

Q: Does Масло чёрного тмина help with Alopecia Areata?

Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that Масло чёрного тмина may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).

Q: How much Масло чёрного тмина should I take for Alopecia Areata?

Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Масло чёрного тмина?

Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Масло чёрного тмина and Alopecia Areata?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.

A Доказательства Несколько крупных клинических испытаний стабильно демонстрируют значительные преимущества.

На основе 25 исследований (4 RCTs) с участием 696 участников. 24/25 исследований показывают положительные эффекты.

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Итог

Black seed oil shows strong research support for alopecia areata, with nearly all studies reporting positive effects, though more human clinical trials are needed to confirm its benefits.

24 out of 25 studies report positive effects, including 4 randomized controlled trials
Thymoquinone, the active compound in black seed oil, has anti-inflammatory and immune-modulating properties
Many studies are preclinical (animal or lab-based), so human evidence is still developing
One case of contact dermatitis from thymoquinone has been reported — patch testing may be advisable

Key Study Findings

Other

Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …

Dose: 80 mg/kg или: None Outcome: Body weight Эффект: None p < 0.05

Популяция: Rat model

Systematic Review

Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.

Dose: Zinc, glutamine, other supplements или: Standard care Outcome: Dysgeusia reduction in chemo patients Эффект: None None

Популяция: Chemotherapy patients with dysgeusia

Other 50 weeks

Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …

Dose: 160 mg/kg или: Control Outcome: None Эффект: None P < 0.05

Популяция: None

Observational Study

Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.

Dose: 1% или: None Outcome: vitamin B12 status Эффект: None None

Популяция: None

Other

Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …

Dose: None или: None Outcome: COVID-19-related diarrhea management Эффект: None None

Популяция: COVID-19 patients with diarrhea

randomized controlled animal experiment n=80 16 weeks

Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …

Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both или: Placebo Эффект: None None

Key Statistics

Исследования

1327

Участники

↔

Mixed

Оценка

Referenced Papers

Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and intestinal microarchitecture in broilers. Other

The veterinary quarterly 2024 15 цитирований

Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity traits in laying hens. Other

Animal science journal … 2024 3 цитирований

Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review. Systematic Review

Clinical nutrition ESPEN 2024

Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans. Other

Roczniki Panstwowego Zakladu … 2023 5 цитирований

Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice. Other

Veterinary medicine and … 2022 7 цитирований

Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen. Other

Nutrition reviews 2022 3 цитирований

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 цитирований

Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. Other

Biological trace element … 2017 35 цитирований

[Therapeutic effects of zinc supplement as adjunctive therapy in infants and young children with rotavirus enteritis]. RCT

Zhongguo dang dai … 2016 9 цитирований

Vitamins and type 2 diabetes mellitus. Review

Endocrine, metabolic & … 2015 171 цитирований

Comparative effects of zinc-nano complexes, zinc-sulphate and zinc-methionine on performance in broiler chickens. Other

British poultry science 2015 98 цитирований

Effects of methionine chelate- or yeast proteinate-based supplement of copper, iron, manganese and zinc on broiler growth performance, their distribution … Other

Biological trace element … 2015 46 цитирований

Zinc supplementation in burn patients. Other

Journal of burn … 2012 16 цитирований

Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. Review

Biological trace element … 2012

Copper and zinc bioaccumulation and bioavailability of Ganoderma lucidum. Other

Journal of medicinal … 2011 29 цитирований

Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. RCT

European journal of … 2010 51 цитирований

Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and … Review

Arthritis research & … 2010 17 цитирований

Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Review

Current opinion in … 2009 66 цитирований

Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. RCT

European journal of … 2009 24 цитирований

Regulation of zinc transporters by dietary zinc supplement in breast cancer. Other

Molecular biology reports 2007 16 цитирований

Zinc supplementation and serum zinc during diarrhea. Other

Indian journal of … 2006 25 цитирований

Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. Review

Pharmacology & therapeutics 2005 199 цитирований

The use and role of zinc and its compounds in wound healing. Review

Metal ions in … 2004

Excessive oral zinc supplementation. Case Report

Journal of pediatric … 2002 80 цитирований

[Iron and zinc supplementation during pregnancy: interactions and requirements]. Review

Contraception, fertilite, sexualite … 1999 11 цитирований

DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc. Other

Cancer detection and … 1998 22 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

hairloss:: 1-2 tsp/day or topical application

Верхний предел: Not established

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
80 mg/kg	--	Neutral	--
Zinc, glutamine, other supplements	--	Positive	--
160 mg/kg	50 weeks	Positive	--
1%	--	Mixed	--
None	--	Positive	--
black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both	16 weeks	Positive	80
104 mg	--	Positive	--
leucine, zinc, and chromium alone/combined	--	Positive	77

Лучшее время приёма: Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Contact dermatitis when applied topically
⚠ Gastrointestinal discomfort
⚠ May lower blood sugar levels
⚠ Possible allergic reactions

Известные взаимодействия

● Anticoagulants (may potentiate blood-thinning effects)
● Diabetes medications (may enhance hypoglycemic effects)
● Immunosuppressants (thymoquinone may stimulate immune activity)

Допустимый верхний уровень потребления: Not established

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Масло чёрного тмина help with Alopecia Areata?

Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that Масло чёрного тмина may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).

How much Масло чёрного тмина should I take for Alopecia Areata?

Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Масло чёрного тмина?

Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Масло чёрного тмина and Alopecia Areata?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.

Другие ингредиенты для Alopecia Areata

Minoxidil A Витамин D A PRP-терапия A Микронидлинг A Женьшень C Цинк F

Масло чёрного тмина для других состояний

Телогеновый эффлувиум A

Краткий вывод

На основе 25 исследований (4 RCTs) с участием 696 участников. 24/25 исследований показывают положительные эффекты.

Evidence Strength92%

High confidence

Разбор исследований

RCT (4)Meta (0)Other (21)

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References

[1] Muhammad Ishtiaq Khan et al.. Vet Q. 2024. Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and intestinal microarchitecture in broilers. doi:10.1080/01652176.2023.2298491 PubMed
[2] Ali Afshar Bakeshlo et al.. Anim Sci J. 2024. Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity traits in laying hens. doi:10.1111/asj.13996 PubMed
[3] Beatrice Mazzoleni et al.. Clin Nutr ESPEN. 2024. Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review. doi:10.1016/j.clnesp.2024.05.026 PubMed
[4] Radek Latal et al.. Rocz Panstw Zakl Hig. 2023. Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans. doi:10.32394/rpzh.2023.0259 PubMed
[5] Afrina Mustari et al.. Vet Med Sci. 2022. Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice. doi:10.1002/vms3.708 PubMed
[6] Heitor O Santos. Nutr Rev. 2022. Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen. doi:10.1093/nutrit/nuab054 PubMed
[7] M N Chang et al.. J Dairy Sci. 2020. Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … doi:10.3168/jds.2019-17610 PubMed
[8] Hassan Sadri et al.. Biol Trace Elem Res. 2017. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. doi:10.1007/s12011-017-1014-2 PubMed
[9] Chao-Xiong Jiang et al.. Zhongguo Dang Dai Er Ke Za Zhi. 2016. [Therapeutic effects of zinc supplement as adjunctive therapy in infants and young children with rotavirus enteritis]. doi:10.7499/j.issn.1008-8830.2016.09.008 PubMed
[10] Roxana Valdés-Ramos et al.. Endocr Metab Immune Disord Drug Targets. 2015. Vitamins and type 2 diabetes mellitus. doi:10.2174/1871530314666141111103217 PubMed
[11] V Mohammadi et al.. Br Poult Sci. 2015. Comparative effects of zinc-nano complexes, zinc-sulphate and zinc-methionine on performance in broiler chickens. doi:10.1080/00071668.2015.1064093 PubMed
[12] Abhay Kumar Singh et al.. Biol Trace Elem Res. 2015. Effects of methionine chelate- or yeast proteinate-based supplement of copper, iron, manganese and zinc on broiler growth performance, their distribution … doi:10.1007/s12011-014-0222-2 PubMed
[13] Nancy Caldis-Coutris et al.. J Burn Care Res. 2012. Zinc supplementation in burn patients. doi:10.1097/BCR.0b013e31824799a3 PubMed
[14] Alemu Hunde et al.. Biol Trace Elem Res. 2012. Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. doi:10.1007/s12011-011-9310-8 PubMed
[15] Ramiro González Matute et al.. J Med Food. 2011. Copper and zinc bioaccumulation and bioavailability of Ganoderma lucidum. doi:10.1089/jmf.2010.0206 PubMed
[16] S Chang et al.. Eur J Clin Nutr. 2010. Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. doi:10.1038/ejcn.2009.127 PubMed
[17] Robin Christensen et al.. Arthritis Res Ther. 2010. Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and … doi:10.1186/ar2909 PubMed
[18] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
[19] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
[20] Daoxu Sun et al.. Mol Biol Rep. 2007. Regulation of zinc transporters by dietary zinc supplement in breast cancer. doi:10.1007/s11033-007-9082-6 PubMed
[21] Abdullah H Baqui et al.. Indian J Pediatr. 2006. Zinc supplementation and serum zinc during diarrhea. doi:10.1007/BF02759893 PubMed
[22] Peter D Zalewski et al.. Pharmacol Ther. 2005. Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. doi:10.1016/j.pharmthera.2004.09.004 PubMed
[23] Paul W Jones et al.. Met Ions Biol Syst. 2004. The use and role of zinc and its compounds in wound healing. PubMed
[24] Mark B Salzman et al.. J Pediatr Hematol Oncol. 2002. Excessive oral zinc supplementation. doi:10.1097/00043426-200210000-00020 PubMed
[25] D Bouglé et al.. Contracept Fertil Sex. 1999. [Iron and zinc supplementation during pregnancy: interactions and requirements]. PubMed
[26] Y Sheng et al.. Cancer Detect Prev. 1998. DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc. doi:10.1046/j.1525-1500.1998.cdoa37.x PubMed

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