Óleo de semente preta para Alopecia Areata
A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.Baseado em 25 estudos (4 RCTs) com 696 participantes no total. 24/25 estudos mostram efeitos positivos.
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A
Conclusão
Black seed oil shows strong research support for alopecia areata, with nearly all studies reporting positive effects, though more human clinical trials are needed to confirm its benefits.
- 24 out of 25 studies report positive effects, including 4 randomized controlled trials
- Thymoquinone, the active compound in black seed oil, has anti-inflammatory and immune-modulating properties
- Many studies are preclinical (animal or lab-based), so human evidence is still developing
- One case of contact dermatitis from thymoquinone has been reported — patch testing may be advisable
Key Study Findings
Other
Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …
Dose: 80 mg/kg
vs: None
Outcome: Body weight
Efeito: None
p < 0.05
População: Rat model
Systematic Review
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Dose: Zinc, glutamine, other supplements
vs: Standard care
Outcome: Dysgeusia reduction in chemo patients
Efeito: None
None
População: Chemotherapy patients with dysgeusia
Other
50 weeks
Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …
Dose: 160 mg/kg
vs: Control
Outcome: None
Efeito: None
P < 0.05
População: None
Observational Study
Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.
Dose: 1%
vs: None
Outcome: vitamin B12 status
Efeito: None
None
População: None
Other
Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …
Dose: None
vs: None
Outcome: COVID-19-related diarrhea management
Efeito: None
None
População: COVID-19 patients with diarrhea
randomized controlled animal experiment
n=80
16 weeks
Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …
Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both
vs: Placebo
Efeito: None
None
Key Statistics
25
Estudos
1327
Participantes
↔
Mixed
A
Nota
Referenced Papers
The veterinary quarterly
2024
15 citações
Animal science journal …
2024
3 citações
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Systematic Review
Clinical nutrition ESPEN
2024
Roczniki Panstwowego Zakladu …
2023
5 citações
Veterinary medicine and …
2022
7 citações
Nutrition reviews
2022
3 citações
Journal of dairy …
2020
58 citações
Biological trace element …
2017
35 citações
Zhongguo dang dai …
2016
9 citações
Endocrine, metabolic & …
2015
171 citações
British poultry science
2015
98 citações
Biological trace element …
2015
46 citações
Journal of burn …
2012
16 citações
Biological trace element …
2012
Journal of medicinal …
2011
29 citações
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 citações
Arthritis research & …
2010
17 citações
Current opinion in …
2009
66 citações
European journal of …
2009
24 citações
Molecular biology reports
2007
16 citações
Indian journal of …
2006
25 citações
Pharmacology & therapeutics
2005
199 citações
Metal ions in …
2004
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 citações
Contraception, fertilite, sexualite …
1999
11 citações
Cancer detection and …
1998
22 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- hairloss:
- 1-2 tsp/day or topical application
Limite superior: Not established
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| 80 mg/kg | -- | Neutral | -- |
| Zinc, glutamine, other supplements | -- | Positive | -- |
| 160 mg/kg | 50 weeks | Positive | -- |
| 1% | -- | Mixed | -- |
| None | -- | Positive | -- |
| black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both | 16 weeks | Positive | 80 |
| 104 mg | -- | Positive | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
Melhor horário: Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Contact dermatitis when applied topically
- ⚠ Gastrointestinal discomfort
- ⚠ May lower blood sugar levels
- ⚠ Possible allergic reactions
Interações Conhecidas
- ● Anticoagulants (may potentiate blood-thinning effects)
- ● Diabetes medications (may enhance hypoglycemic effects)
- ● Immunosuppressants (thymoquinone may stimulate immune activity)
Ingestão máxima tolerável: Not established
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Óleo de semente preta help with Alopecia Areata?
Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that Óleo de semente preta may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).
How much Óleo de semente preta should I take for Alopecia Areata?
Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Óleo de semente preta?
Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Óleo de semente preta and Alopecia Areata?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.
Related Evidence
Outros ingredientes para Alopecia Areata
Óleo de semente preta para outras condições
References
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- [2] Ali Afshar Bakeshlo et al.. Anim Sci J. 2024. Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity traits in laying hens. doi:10.1111/asj.13996 PubMed
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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.