黑种草油 用于 斑秃
A 证据 多项大型临床试验一致显示出显著的益处。基于25项研究（4项RCT），共696名参与者。24/25项研究显示积极效果。
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A
结论
Black seed oil shows strong research support for alopecia areata, with nearly all studies reporting positive effects, though more human clinical trials are needed to confirm its benefits.
- 24 out of 25 studies report positive effects, including 4 randomized controlled trials
- Thymoquinone, the active compound in black seed oil, has anti-inflammatory and immune-modulating properties
- Many studies are preclinical (animal or lab-based), so human evidence is still developing
- One case of contact dermatitis from thymoquinone has been reported — patch testing may be advisable
Key Study Findings
Other
Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …
Dose: 80 mg/kg
vs: None
Outcome: Body weight
效果: None
p < 0.05
研究人群: Rat model
Systematic Review
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Dose: Zinc, glutamine, other supplements
vs: Standard care
Outcome: Dysgeusia reduction in chemo patients
效果: None
None
研究人群: Chemotherapy patients with dysgeusia
Other
50 weeks
Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …
Dose: 160 mg/kg
vs: Control
Outcome: None
效果: None
P < 0.05
研究人群: None
Observational Study
Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.
Dose: 1%
vs: None
Outcome: vitamin B12 status
效果: None
None
研究人群: None
Other
Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …
Dose: None
vs: None
Outcome: COVID-19-related diarrhea management
效果: None
None
研究人群: COVID-19 patients with diarrhea
randomized controlled animal experiment
n=80
16 weeks
Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …
Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both
vs: Placebo
效果: None
None
Key Statistics
25
研究数量
1327
受试者
↔
Mixed
A
等级
Referenced Papers
The veterinary quarterly
2024
15 次引用
Animal science journal …
2024
3 次引用
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Systematic Review
Clinical nutrition ESPEN
2024
Roczniki Panstwowego Zakladu …
2023
5 次引用
Veterinary medicine and …
2022
7 次引用
Nutrition reviews
2022
3 次引用
Journal of dairy …
2020
58 次引用
Biological trace element …
2017
35 次引用
Zhongguo dang dai …
2016
9 次引用
Endocrine, metabolic & …
2015
171 次引用
British poultry science
2015
98 次引用
Biological trace element …
2015
46 次引用
Journal of burn …
2012
16 次引用
Biological trace element …
2012
Journal of medicinal …
2011
29 次引用
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 次引用
Arthritis research & …
2010
17 次引用
Current opinion in …
2009
66 次引用
European journal of …
2009
24 次引用
Molecular biology reports
2007
16 次引用
Indian journal of …
2006
25 次引用
Pharmacology & therapeutics
2005
199 次引用
Metal ions in …
2004
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 次引用
Contraception, fertilite, sexualite …
1999
11 次引用
Cancer detection and …
1998
22 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- hairloss:
- 1-2 tsp/day or topical application
上限： Not established
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 80 mg/kg | -- | Neutral | -- |
| Zinc, glutamine, other supplements | -- | Positive | -- |
| 160 mg/kg | 50 weeks | Positive | -- |
| 1% | -- | Mixed | -- |
| None | -- | Positive | -- |
| black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both | 16 weeks | Positive | 80 |
| 104 mg | -- | Positive | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
最佳服用时间： Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing
Safety & Side Effects
已报告的副作用
- ⚠ Contact dermatitis when applied topically
- ⚠ Gastrointestinal discomfort
- ⚠ May lower blood sugar levels
- ⚠ Possible allergic reactions
已知相互作用
- ● Anticoagulants (may potentiate blood-thinning effects)
- ● Diabetes medications (may enhance hypoglycemic effects)
- ● Immunosuppressants (thymoquinone may stimulate immune activity)
可耐受最高摄入量： Not established
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 黑种草油 help with 斑秃?
Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that 黑种草油 may support 斑秃 management. Our evidence grade is A (Strong Evidence).
How much 黑种草油 should I take for 斑秃?
Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 黑种草油?
Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 黑种草油 and 斑秃?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.
Related Evidence
References
- [1] Muhammad Ishtiaq Khan et al.. Vet Q. 2024. Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and intestinal microarchitecture in broilers. doi:10.1080/01652176.2023.2298491 PubMed
- [2] Ali Afshar Bakeshlo et al.. Anim Sci J. 2024. Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity traits in laying hens. doi:10.1111/asj.13996 PubMed
- [3] Beatrice Mazzoleni et al.. Clin Nutr ESPEN. 2024. Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review. doi:10.1016/j.clnesp.2024.05.026 PubMed
- [4] Radek Latal et al.. Rocz Panstw Zakl Hig. 2023. Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans. doi:10.32394/rpzh.2023.0259 PubMed
- [5] Afrina Mustari et al.. Vet Med Sci. 2022. Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice. doi:10.1002/vms3.708 PubMed
- [6] Heitor O Santos. Nutr Rev. 2022. Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen. doi:10.1093/nutrit/nuab054 PubMed
- [7] M N Chang et al.. J Dairy Sci. 2020. Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … doi:10.3168/jds.2019-17610 PubMed
- [8] Hassan Sadri et al.. Biol Trace Elem Res. 2017. Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. doi:10.1007/s12011-017-1014-2 PubMed
- [9] Chao-Xiong Jiang et al.. Zhongguo Dang Dai Er Ke Za Zhi. 2016. [Therapeutic effects of zinc supplement as adjunctive therapy in infants and young children with rotavirus enteritis]. doi:10.7499/j.issn.1008-8830.2016.09.008 PubMed
- [10] Roxana Valdés-Ramos et al.. Endocr Metab Immune Disord Drug Targets. 2015. Vitamins and type 2 diabetes mellitus. doi:10.2174/1871530314666141111103217 PubMed
- [11] V Mohammadi et al.. Br Poult Sci. 2015. Comparative effects of zinc-nano complexes, zinc-sulphate and zinc-methionine on performance in broiler chickens. doi:10.1080/00071668.2015.1064093 PubMed
- [12] Abhay Kumar Singh et al.. Biol Trace Elem Res. 2015. Effects of methionine chelate- or yeast proteinate-based supplement of copper, iron, manganese and zinc on broiler growth performance, their distribution … doi:10.1007/s12011-014-0222-2 PubMed
- [13] Nancy Caldis-Coutris et al.. J Burn Care Res. 2012. Zinc supplementation in burn patients. doi:10.1097/BCR.0b013e31824799a3 PubMed
- [14] Alemu Hunde et al.. Biol Trace Elem Res. 2012. Supplementation of poultry feeds with dietary zinc and other minerals and compounds to mitigate nitrogen emissions--a review. doi:10.1007/s12011-011-9310-8 PubMed
- [15] Ramiro González Matute et al.. J Med Food. 2011. Copper and zinc bioaccumulation and bioavailability of Ganoderma lucidum. doi:10.1089/jmf.2010.0206 PubMed
- [16] S Chang et al.. Eur J Clin Nutr. 2010. Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. doi:10.1038/ejcn.2009.127 PubMed
- [17] Robin Christensen et al.. Arthritis Res Ther. 2010. Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and … doi:10.1186/ar2909 PubMed
- [18] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [19] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [20] Daoxu Sun et al.. Mol Biol Rep. 2007. Regulation of zinc transporters by dietary zinc supplement in breast cancer. doi:10.1007/s11033-007-9082-6 PubMed
- [21] Abdullah H Baqui et al.. Indian J Pediatr. 2006. Zinc supplementation and serum zinc during diarrhea. doi:10.1007/BF02759893 PubMed
- [22] Peter D Zalewski et al.. Pharmacol Ther. 2005. Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. doi:10.1016/j.pharmthera.2004.09.004 PubMed
- [23] Paul W Jones et al.. Met Ions Biol Syst. 2004. The use and role of zinc and its compounds in wound healing. PubMed
- [24] Mark B Salzman et al.. J Pediatr Hematol Oncol. 2002. Excessive oral zinc supplementation. doi:10.1097/00043426-200210000-00020 PubMed
- [25] D Bouglé et al.. Contracept Fertil Sex. 1999. [Iron and zinc supplementation during pregnancy: interactions and requirements]. PubMed
- [26] Y Sheng et al.. Cancer Detect Prev. 1998. DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc. doi:10.1046/j.1525-1500.1998.cdoa37.x PubMed
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