亜鉛：休止期脱毛症

合計30,246名の参加者を対象とした29件の研究（RCT 3件を含む）に基づく。研究間で結果にばらつきが見られる。

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結論

Moderate evidence suggests that zinc deficiency may contribute to telogen effluvium, and supplementation may help if levels are low — but routine zinc supplementation for hair shedding is not clearly supported.

Lower zinc levels are frequently found in telogen effluvium patients
Some RCTs show benefits from zinc-containing supplement combinations
Difficult to isolate zinc's specific effect from multi-ingredient formulas
Testing zinc levels and supplementing only if deficient is a reasonable approach

Key Study Findings

Prospective Open-Label Interventional Study n=343 4 weeks Open-label

Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium.

Dose: Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month vs: Placebo 効果: Significant improvements in all hair parameters at T1 and T2 (P < 0.001) p<0.001

Retrospective Cross-Sectional Study n=23975

Hair Loss and Zinc Deficiency: A Cross-Sectional Study.

Dose: None vs: Placebo 効果: Median zinc 96 µg/dL (hair loss) vs 99 µg/dL (control); statistically significant but clinically min p<0.001

cross-sectional study

Zinc Status in Kurdish Adults With Hair Loss.

Dose: None vs: Placebo 効果: None None

Case-Control Study n=100

Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia.

Dose: None vs: Placebo 効果: None 0.05

case-control study n=180

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …

Dose: not applicable vs: Placebo 効果: None None

Case-control n=100

Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value …

Dose: None vs: Placebo 効果: None None

Key Statistics

研究数

30246

参加者数

↔

Mixed

グレード

Referenced Papers

Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium. Other

International journal of … 2025

Hair Loss and Zinc Deficiency: A Cross-Sectional Study. Other

Healthcare (Basel, Switzerland) 2025

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … Other

Journal of cosmetic … 2024 7 件の引用

Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value of dietary supplements. a case … Other

Archives of dermatological … 2024 5 件の引用

Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. Other

JPMA. The Journal … 2024 2 件の引用

Cost-effectiveness analysis of laboratory monitoring in newly diagnosed telogen effluvium patients. Other

Archives of dermatological … 2024 1 件の引用

Zinc Status in Kurdish Adults With Hair Loss. Other

Cureus 2024 1 件の引用

"Shedding" low yield testing for telogen effluvium: A cross-sectional study of 16,381 laboratory results from newly diagnosed patients. Other

Journal of the … 2023 5 件の引用

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. Other

Dermatology practical & … 2023 4 件の引用

Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) … Other

Italian journal of … 2023 4 件の引用

Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … Other

Italian journal of … 2023 3 件の引用

Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. Other

Journal of cosmetic … 2022 22 件の引用

The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy. Review

Human nutrition & … 2022 9 件の引用

Supplementation and hair growth: A retrospective chart review of patients with alopecia and laboratory abnormalities. Other

JAAD international 2022 6 件の引用

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. Other

Dermatology reports 2022 4 件の引用

A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. RCT

Italian journal of … 2022 2 件の引用

Laboratory Testing in Telogen Effluvium. Other

Journal of drugs … 2021 3 件の引用

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Other

Clinical, cosmetic and … 2018 16 件の引用

Assessment of Heavy Metal and Trace Element Levels in Patients with Telogen Effluvium. Other

Indian journal of … 2018 14 件の引用

Prevalence of Nutritional Deficiencies in Hair Loss among Indian Participants: Results of a Cross-sectional Study. Other

International journal of … 2017 43 件の引用

Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. Other

Journal of drugs … 2016 56 件の引用

Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Other

International journal of … 2016 28 件の引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 件の引用

Possible Relationship between Chronic Telogen Effluvium and Changes in Lead, Cadmium, Zinc, and Iron Total Blood Levels in Females: A … Other

International journal of … 2015 18 件の引用

Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. Other

Journal of cutaneous … 2014 10 件の引用

Analysis of serum zinc and copper concentrations in hair loss. Other

Annals of dermatology 2013 114 件の引用

Hair loss in children: common and uncommon causes; clinical and epidemiological study in jordan. Other

International journal of … 2013 37 件の引用

Oral zinc therapy for zinc deficiency-related telogen effluvium. Case Report

Dermatologic therapy 2012 31 件の引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 件の引用

The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. Review

Journal of the … 2006 255 件の引用

Dermatologic signs in patients with eating disorders. Review

American journal of … 2005 140 件の引用

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. Other

International journal of … 2002 53 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-11 mg/day
hairloss:: 15-30 mg/day

上限量： 40 mg/day

研究で検討された用量

用量	期間	効果	N
Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month	4 weeks	Positive	343
None	--	Neutral	23975
None	--	Neutral	--
None	--	Negative	100
not applicable	--	Mixed	180
None	--	Mixed	100
None	--	Mixed	--
4 tablets daily (arginine, l-cystine, zinc, vitamin B6)	12 weeks	Positive	20

推奨摂取タイミング： With meals to minimize stomach upset; separate from iron and calcium by 2 hours

Safety & Side Effects

報告されている副作用

⚠ Nausea and vomiting (especially on an empty stomach)
⚠ Metallic taste in the mouth
⚠ Copper depletion with chronic high-dose use
⚠ Headache and diarrhea

既知の相互作用

● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)

耐容上限摂取量： 40 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does 亜鉛 help with 休止期脱毛症?

Based on 32 studies with 30,246 participants, there is insufficient evidence at this time that 亜鉛 may support 休止期脱毛症 management. Our evidence grade is F (Evidence Against).

How much 亜鉛 should I take for 休止期脱毛症?

Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 亜鉛?

Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use, Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 亜鉛 and 休止期脱毛症?

We rate the evidence as Grade F (Evidence Against). This rating is based on 32 peer-reviewed studies with 30,246 total participants. The overall direction of effect is mixed.

Related Evidence

に関する他の成分：休止期脱毛症

ミノキシジル A ブラックシードオイル A ビビスカル A 鉄 B ケラチン B オメガ3脂肪酸 B

亜鉛他の症状・状態について

男性型・女性型脱毛症（AGA） A 円形脱毛症 F

総合評価

合計30,246名の参加者を対象とした29件の研究（RCT 3件を含む）に基づく。研究間で結果にばらつきが見られる。

Evidence Strength10%

Low confidence

研究の内訳

RCT (1)Meta (0)Other (31)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る：休止期脱毛症

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。