葉酸 ： 休止期脱毛症
B合計4,166名の参加者を対象とした6件の研究に基づく。研究間で結果にばらつきが見られる。
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B
結論
There is limited evidence connecting folate to telogen effluvium — while low folate levels have been observed in some patients, research does not yet support folate supplementation as a reliable approach for this condition.
- Mixed results across 6 studies — no consistent pattern linking folate levels to telogen effluvium
- All studies are observational; no randomized controlled trials exist for this specific use
- Folate is one of many micronutrients that may play a supporting role in hair health
- A comprehensive nutritional assessment may be more useful than supplementing folate alone
Key Study Findings
Retrospective cohort
n=2851
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Dose: None
vs: Placebo
効果: Ferritin low in 46.5% of patients; iron deficiency in 29.5%
p<0.05
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
効果: None
None
Cross-Sectional Study
n=108
Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with …
Dose: None
vs: Placebo
効果: None
0.05
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
効果: r=0.417 (HGB and AHR in females)
p=0.008
retrospective cohort study
n=3028
Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients …
Dose: standard replacement doses
vs: Placebo
効果: vitamin D deficient: 72.2%; B12 deficient: 30.7%; iron deficiency anemia: 6.2%
None
randomized controlled trial
26 weeks
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Dose: recommended daily intake amounts; taken orally for 180 days
vs: Placebo
効果: Group 1 trichoscopy improvement 11.09% vs Group 2 7.76% after 180 days (significant for Group 1 only
P<0.05 for clinical parameters
Key Statistics
10
研究数
7126
参加者数
↔
Mixed
B
グレード
Referenced Papers
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Other
Journal of cosmetic …
2025
4 件の引用
Nutrients
2025
2 件の引用
Northern clinics of …
2024
1 件の引用
Dermatology practical & …
2023
4 件の引用
Journal of cosmetic …
2022
22 件の引用
Journal of photochemistry …
2018
16 件の引用
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 件の引用
Journal of drugs …
2016
56 件の引用
Acta dermatovenerologica Croatica …
2016
6 件の引用
Clinical and experimental …
2009
34 件の引用
Dermatologic clinics
1993
38 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 400 mcg DFE/day
上限量： 1,000 mcg/day (synthetic folic acid)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Neutral | 2851 |
| None | -- | Mixed | -- |
| None | -- | Mixed | 108 |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| psychiatric and dermatological management | -- | Neutral | 1 |
| None | -- | Negative | -- |
推奨摂取タイミング： With meals for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
既知の相互作用
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
耐容上限摂取量： 1,000 mcg/day (synthetic folic acid)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does 葉酸 help with 休止期脱毛症?
Based on 10 studies with 7,126 participants, there is moderate evidence from clinical studies that 葉酸 may support 休止期脱毛症 management. Our evidence grade is B (Good Evidence).
How much 葉酸 should I take for 休止期脱毛症?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 葉酸?
Reported side effects may include Generally well tolerated, May mask vitamin B12 deficiency symptoms at high doses, Rare: abdominal cramps, insomnia. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 葉酸 and 休止期脱毛症?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 7,126 total participants. The overall direction of effect is mixed.
Related Evidence
葉酸 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。