ブラックシードオイル ： 円形脱毛症
A合計696名の参加者を対象とした25件の研究（RCT 4件を含む）に基づく。25件中24件の研究で肯定的な効果が示されている。
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A
結論
Black seed oil shows strong research support for alopecia areata, with nearly all studies reporting positive effects, though more human clinical trials are needed to confirm its benefits.
- 24 out of 25 studies report positive effects, including 4 randomized controlled trials
- Thymoquinone, the active compound in black seed oil, has anti-inflammatory and immune-modulating properties
- Many studies are preclinical (animal or lab-based), so human evidence is still developing
- One case of contact dermatitis from thymoquinone has been reported — patch testing may be advisable
Key Study Findings
Other
Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …
Dose: 80 mg/kg
vs: None
Outcome: Body weight
効果: None
p < 0.05
対象集団: Rat model
Systematic Review
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Dose: Zinc, glutamine, other supplements
vs: Standard care
Outcome: Dysgeusia reduction in chemo patients
効果: None
None
対象集団: Chemotherapy patients with dysgeusia
Other
50 weeks
Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …
Dose: 160 mg/kg
vs: Control
Outcome: None
効果: None
P < 0.05
対象集団: None
Observational Study
Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.
Dose: 1%
vs: None
Outcome: vitamin B12 status
効果: None
None
対象集団: None
Other
Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …
Dose: None
vs: None
Outcome: COVID-19-related diarrhea management
効果: None
None
対象集団: COVID-19 patients with diarrhea
randomized controlled animal experiment
n=80
16 weeks
Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …
Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both
vs: Placebo
効果: None
None
Key Statistics
25
研究数
1327
参加者数
↔
Mixed
A
グレード
Referenced Papers
The veterinary quarterly
2024
15 件の引用
Animal science journal …
2024
3 件の引用
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Systematic Review
Clinical nutrition ESPEN
2024
Roczniki Panstwowego Zakladu …
2023
5 件の引用
Veterinary medicine and …
2022
7 件の引用
Nutrition reviews
2022
3 件の引用
Journal of dairy …
2020
58 件の引用
Biological trace element …
2017
35 件の引用
Zhongguo dang dai …
2016
9 件の引用
Endocrine, metabolic & …
2015
171 件の引用
British poultry science
2015
98 件の引用
Biological trace element …
2015
46 件の引用
Journal of burn …
2012
16 件の引用
Biological trace element …
2012
Journal of medicinal …
2011
29 件の引用
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 件の引用
Arthritis research & …
2010
17 件の引用
Current opinion in …
2009
66 件の引用
European journal of …
2009
24 件の引用
Molecular biology reports
2007
16 件の引用
Indian journal of …
2006
25 件の引用
Pharmacology & therapeutics
2005
199 件の引用
Metal ions in …
2004
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 件の引用
Contraception, fertilite, sexualite …
1999
11 件の引用
Cancer detection and …
1998
22 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- hairloss:
- 1-2 tsp/day or topical application
上限量： Not established
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 80 mg/kg | -- | Neutral | -- |
| Zinc, glutamine, other supplements | -- | Positive | -- |
| 160 mg/kg | 50 weeks | Positive | -- |
| 1% | -- | Mixed | -- |
| None | -- | Positive | -- |
| black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both | 16 weeks | Positive | 80 |
| 104 mg | -- | Positive | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
推奨摂取タイミング： Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing
Safety & Side Effects
報告されている副作用
- ⚠ Contact dermatitis when applied topically
- ⚠ Gastrointestinal discomfort
- ⚠ May lower blood sugar levels
- ⚠ Possible allergic reactions
既知の相互作用
- ● Anticoagulants (may potentiate blood-thinning effects)
- ● Diabetes medications (may enhance hypoglycemic effects)
- ● Immunosuppressants (thymoquinone may stimulate immune activity)
耐容上限摂取量： Not established
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does ブラックシードオイル help with 円形脱毛症?
Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that ブラックシードオイル may support 円形脱毛症 management. Our evidence grade is A (Strong Evidence).
How much ブラックシードオイル should I take for 円形脱毛症?
Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of ブラックシードオイル?
Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for ブラックシードオイル and 円形脱毛症?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.
Related Evidence
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。