Folate for Nutritional Deficiency Hair Loss
FBased on 11 studies with 4,166 total participants. Results are mixed across studies.
The Bottom Line
The evidence linking folate supplementation to hair regrowth is limited and mixed — folate deficiency may contribute to hair loss in some cases, but supplementation is not well-supported as a general hair loss remedy.
- Results are mixed across 11 studies, with no clear consensus on folate's role in hair loss
- No randomized controlled trials have specifically tested folate supplementation for hair regrowth
- Folate deficiency may be more relevant when caused by medications (e.g., methotrexate) rather than diet
- Blood testing for folate levels may help determine if supplementation is appropriate
Key Study Findings
Population: Primary human hepatocytes and HepG2 cells
Population: Review of pharmacogenomics of THC and CBD
Population: Cows
Key Statistics
11
Studies
4166
Participants
Mixed
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 400 mcg DFE/day
Upper limit: 1,000 mcg/day (synthetic folic acid)
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 10.2% d | 2 weeks | Mixed | -- |
| None | -- | Positive | 973 |
| standard replacement doses | -- | Neutral | 3028 |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
Best taken: With meals for better absorption
Safety & Side Effects
Reported Side Effects
- ⚠ Generally well tolerated
- ⚠ May mask vitamin B12 deficiency symptoms at high doses
- ⚠ Rare: abdominal cramps, insomnia
Known Interactions
- ● Methotrexate (folate antagonist; consult physician)
- ● Anticonvulsants (phenytoin, carbamazepine) may reduce folate levels
- ● Sulfasalazine (reduces folate absorption)
Tolerable upper intake: 1,000 mcg/day (synthetic folic acid)
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Folate help with Nutritional Deficiency Hair Loss?
How much Folate should I take for Nutritional Deficiency Hair Loss?
Are there side effects of Folate?
How strong is the evidence for Folate and Nutritional Deficiency Hair Loss?
Related Evidence
Other ingredients for Nutritional Deficiency Hair Loss
Folate for other conditions
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.