زيت الحبة السوداء لـ Alopecia Areata (الثعلبة البقعية)
Aبناءً على 25 دراسة (4 RCTs) بمشاركة 696 مشاركًا إجمالاً. 24/25 دراسة تُظهر تأثيرات إيجابية.
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A
الخلاصة
Black seed oil shows strong research support for alopecia areata, with nearly all studies reporting positive effects, though more human clinical trials are needed to confirm its benefits.
- 24 out of 25 studies report positive effects, including 4 randomized controlled trials
- Thymoquinone, the active compound in black seed oil, has anti-inflammatory and immune-modulating properties
- Many studies are preclinical (animal or lab-based), so human evidence is still developing
- One case of contact dermatitis from thymoquinone has been reported — patch testing may be advisable
Key Study Findings
Other
Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and …
Dose: 80 mg/kg
مقابل: None
Outcome: Body weight
التأثير: None
p < 0.05
المجتمع المدروس: Rat model
Systematic Review
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Dose: Zinc, glutamine, other supplements
مقابل: Standard care
Outcome: Dysgeusia reduction in chemo patients
التأثير: None
None
المجتمع المدروس: Chemotherapy patients with dysgeusia
Other
50 weeks
Comparative effects of zinc hydroxy chloride, zinc sulfate, and zinc-methionine on egg quality and quantity …
Dose: 160 mg/kg
مقابل: Control
Outcome: None
التأثير: None
P < 0.05
المجتمع المدروس: None
Observational Study
Cross sectional study of vitamin B12 supplementation in Slovak and Czech vegans.
Dose: 1%
مقابل: None
Outcome: vitamin B12 status
التأثير: None
None
المجتمع المدروس: None
Other
Therapeutic supplementation with zinc in the management of COVID-19-related diarrhea and ageusia/dysgeusia: mechanisms and clues …
Dose: None
مقابل: None
Outcome: COVID-19-related diarrhea management
التأثير: None
None
المجتمع المدروس: COVID-19 patients with diarrhea
randomized controlled animal experiment
n=80
16 weeks
Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture …
Dose: black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both
مقابل: Placebo
التأثير: None
None
Key Statistics
25
الدراسات
1327
المشاركون
↔
Mixed
A
التقييم
Referenced Papers
The veterinary quarterly
2024
15 اقتباسات
Animal science journal …
2024
3 اقتباسات
Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
Systematic Review
Clinical nutrition ESPEN
2024
Roczniki Panstwowego Zakladu …
2023
5 اقتباسات
Veterinary medicine and …
2022
7 اقتباسات
Nutrition reviews
2022
3 اقتباسات
Journal of dairy …
2020
58 اقتباسات
Biological trace element …
2017
35 اقتباسات
Zhongguo dang dai …
2016
9 اقتباسات
Endocrine, metabolic & …
2015
171 اقتباسات
British poultry science
2015
98 اقتباسات
Biological trace element …
2015
46 اقتباسات
Journal of burn …
2012
16 اقتباسات
Biological trace element …
2012
Journal of medicinal …
2011
29 اقتباسات
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
RCT
European journal of …
2010
51 اقتباسات
Arthritis research & …
2010
17 اقتباسات
Current opinion in …
2009
66 اقتباسات
European journal of …
2009
24 اقتباسات
Molecular biology reports
2007
16 اقتباسات
Indian journal of …
2006
25 اقتباسات
Pharmacology & therapeutics
2005
199 اقتباسات
Metal ions in …
2004
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 اقتباسات
Contraception, fertilite, sexualite …
1999
11 اقتباسات
Cancer detection and …
1998
22 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- hairloss:
- 1-2 tsp/day or topical application
الحد الأعلى: Not established
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| 80 mg/kg | -- | Neutral | -- |
| Zinc, glutamine, other supplements | -- | Positive | -- |
| 160 mg/kg | 50 weeks | Positive | -- |
| 1% | -- | Mixed | -- |
| None | -- | Positive | -- |
| black seed oil 0.5 ml/kg/day; vitamin E 200 mg/kg/day; combination of both | 16 weeks | Positive | 80 |
| 104 mg | -- | Positive | -- |
| leucine, zinc, and chromium alone/combined | -- | Positive | 77 |
أفضل وقت للتناول: Oral: with meals; Topical: massage into scalp and leave for 30 minutes before washing
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Contact dermatitis when applied topically
- ⚠ Gastrointestinal discomfort
- ⚠ May lower blood sugar levels
- ⚠ Possible allergic reactions
التفاعلات المعروفة
- ● Anticoagulants (may potentiate blood-thinning effects)
- ● Diabetes medications (may enhance hypoglycemic effects)
- ● Immunosuppressants (thymoquinone may stimulate immune activity)
الحد الأقصى المسموح به: Not established
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does زيت الحبة السوداء help with Alopecia Areata (الثعلبة البقعية)?
Based on 25 studies with 1,327 participants, there is strong evidence from multiple clinical trials that زيت الحبة السوداء may support Alopecia Areata (الثعلبة البقعية) management. Our evidence grade is A (Strong Evidence).
How much زيت الحبة السوداء should I take for Alopecia Areata (الثعلبة البقعية)?
Studies have used various dosages. A commonly studied range is 1-2 tsp/day or topical application. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of زيت الحبة السوداء?
Reported side effects may include Contact dermatitis when applied topically, Gastrointestinal discomfort, May lower blood sugar levels, Possible allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for زيت الحبة السوداء and Alopecia Areata (الثعلبة البقعية)?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 25 peer-reviewed studies with 1,327 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Alopecia Areata (الثعلبة البقعية)
زيت الحبة السوداء لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.