锌 用于 休止期脱发
F基于29项研究（3项RCT），共30,246名参与者。各研究结果不一。
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F
结论
Moderate evidence suggests that zinc deficiency may contribute to telogen effluvium, and supplementation may help if levels are low — but routine zinc supplementation for hair shedding is not clearly supported.
- Lower zinc levels are frequently found in telogen effluvium patients
- Some RCTs show benefits from zinc-containing supplement combinations
- Difficult to isolate zinc's specific effect from multi-ingredient formulas
- Testing zinc levels and supplementing only if deficient is a reasonable approach
Key Study Findings
Prospective Open-Label Interventional Study
n=343
4 weeks
Open-label
Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium.
Dose: Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month
vs: Placebo
效果: Significant improvements in all hair parameters at T1 and T2 (P < 0.001)
p<0.001
Retrospective Cross-Sectional Study
n=23975
Hair Loss and Zinc Deficiency: A Cross-Sectional Study.
Dose: None
vs: Placebo
效果: Median zinc 96 µg/dL (hair loss) vs 99 µg/dL (control); statistically significant but clinically min
p<0.001
cross-sectional study
Zinc Status in Kurdish Adults With Hair Loss.
Dose: None
vs: Placebo
效果: None
None
Case-Control Study
n=100
Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia.
Dose: None
vs: Placebo
效果: None
0.05
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
效果: None
None
Case-control
n=100
Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value …
Dose: None
vs: Placebo
效果: None
None
Key Statistics
32
研究数量
30246
受试者
↔
Mixed
F
等级
Referenced Papers
International journal of …
2025
Healthcare (Basel, Switzerland)
2025
Journal of cosmetic …
2024
7 次引用
Archives of dermatological …
2024
5 次引用
JPMA. The Journal …
2024
2 次引用
Cost-effectiveness analysis of laboratory monitoring in newly diagnosed telogen effluvium patients.
Other
Archives of dermatological …
2024
1 次引用
Cureus
2024
1 次引用
Journal of the …
2023
5 次引用
Dermatology practical & …
2023
4 次引用
Italian journal of …
2023
4 次引用
Italian journal of …
2023
3 次引用
Journal of cosmetic …
2022
22 次引用
Human nutrition & …
2022
9 次引用
JAAD international
2022
6 次引用
Dermatology reports
2022
4 次引用
Italian journal of …
2022
2 次引用
Journal of drugs …
2021
3 次引用
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 次引用
Indian journal of …
2018
14 次引用
International journal of …
2017
43 次引用
Journal of drugs …
2016
56 次引用
International journal of …
2016
28 次引用
Acta dermatovenerologica Croatica …
2016
6 次引用
International journal of …
2015
18 次引用
Journal of cutaneous …
2014
10 次引用
Annals of dermatology
2013
114 次引用
Hair loss in children: common and uncommon causes; clinical and epidemiological study in jordan.
Other
International journal of …
2013
37 次引用
Dermatologic therapy
2012
31 次引用
Clinical and experimental …
2009
34 次引用
Journal of the …
2006
255 次引用
American journal of …
2005
140 次引用
International journal of …
2002
53 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 8-11 mg/day
- hairloss:
- 15-30 mg/day
上限： 40 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| Pilopeptan Intensive (hydrolyzed collagen, Group B vitamins, zinc); daily for 1 month | 4 weeks | Positive | 343 |
| None | -- | Neutral | 23975 |
| None | -- | Neutral | -- |
| None | -- | Negative | 100 |
| not applicable | -- | Mixed | 180 |
| None | -- | Mixed | 100 |
| None | -- | Mixed | -- |
| 4 tablets daily (arginine, l-cystine, zinc, vitamin B6) | 12 weeks | Positive | 20 |
最佳服用时间： With meals to minimize stomach upset; separate from iron and calcium by 2 hours
Safety & Side Effects
已报告的副作用
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use
- ⚠ Headache and diarrhea
已知相互作用
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
可耐受最高摄入量： 40 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 锌 help with 休止期脱发?
Based on 32 studies with 30,246 participants, there is insufficient evidence at this time that 锌 may support 休止期脱发 management. Our evidence grade is F (Evidence Against).
How much 锌 should I take for 休止期脱发?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 锌?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use, Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 锌 and 休止期脱发?
We rate the evidence as Grade F (Evidence Against). This rating is based on 32 peer-reviewed studies with 30,246 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 休止期脱发
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