生物素（Biotin） 用于 休止期脱发
B 证据 至少一项随机试验支持这一结论，结果基本一致。基于9项研究（2项RCT），共484名参与者。各研究结果不一。
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B
结论
Research on biotin for telogen effluvium is mixed — it may help in some cases, especially if biotin levels are low, but it is not a reliable standalone solution for this type of hair shedding.
- Results are mixed across 9 studies — some show benefit, others do not
- Lower serum biotin levels have been observed in some telogen effluvium patients
- Biotin was often studied as part of multi-ingredient supplements, making it hard to isolate its specific effect
- Testing biotin levels before supplementing may help identify who is most likely to benefit
Key Study Findings
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
效果: None
None
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
效果: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
效果: MD=+12.3 hairs/cm2 at 6 months
p<0.05
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
效果: None
None
narrative review
Valproate-associated hair abnormalities: Pathophysiology and management strategies.
Dose: not specified
vs: Placebo
效果: None
None
case-control study
n=80
Biotin Deficiency in Telogen Effluvium: Fact or Fiction?
Dose: None
vs: Placebo
效果: None
None
Key Statistics
9
研究数量
484
受试者
↔
Mixed
B
等级
Referenced Papers
Skin appendage disorders
2025
3 次引用
Nutrients
2025
2 次引用
Journal of drugs …
2025
Journal of cosmetic …
2024
7 次引用
Human psychopharmacology
2022
7 次引用
The Journal of …
2020
7 次引用
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 次引用
Journal of photochemistry …
2018
16 次引用
International journal of …
2016
89 次引用
Journal of cutaneous …
2014
10 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 30 mcg/day
- hairloss:
- 2,500-5,000 mcg/day
上限： No established UL (water-soluble)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| not applicable | -- | Mixed | 180 |
| not specified | -- | Positive | -- |
| None | -- | Neutral | 80 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| None | -- | Neutral | 144 |
最佳服用时间： With meals for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ May interfere with laboratory test results (troponin, thyroid panels)
- ⚠ Rare skin rashes at high doses
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential acne breakouts at doses above 5,000 mcg
已知相互作用
- ● Anticonvulsants (carbamazepine, phenytoin) may reduce biotin levels
- ● Raw egg whites (avidin) bind biotin and reduce absorption
- ● Prolonged antibiotic use may deplete gut bacterial biotin synthesis
可耐受最高摄入量： No established UL (water-soluble)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 生物素（Biotin） help with 休止期脱发?
Based on 9 studies with 484 participants, there is moderate evidence from clinical studies that 生物素（Biotin） may support 休止期脱发 management. Our evidence grade is B (Good Evidence).
How much 生物素（Biotin） should I take for 休止期脱发?
Studies have used various dosages. A commonly studied range is 30 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 生物素（Biotin）?
Reported side effects may include May interfere with laboratory test results (troponin, thyroid panels), Rare skin rashes at high doses, Mild gastrointestinal discomfort, Potential acne breakouts at doses above 5,000 mcg. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 生物素（Biotin） and 休止期脱发?
We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 484 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 休止期脱发
生物素（Biotin） 用于其他健康状况
References
- [1] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [2] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [3] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [4] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
- [5] Samir Kumar Praharaj et al.. Hum Psychopharmacol. 2022. Valproate-associated hair abnormalities: Pathophysiology and management strategies. doi:10.1002/hup.2814 PubMed
- [6] Sherine Hosny Abdel Rahman et al.. J Clin Aesthet Dermatol. 2020. Biotin Deficiency in Telogen Effluvium: Fact or Fiction? PubMed
- [7] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
- [8] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [9] Ralph M Trüeb. Int J Trichology. 2016. Serum Biotin Levels in Women Complaining of Hair Loss. doi:10.4103/0974-7753.188040 PubMed
- [10] Thamer Mubki. J Cutan Med Surg. 2014. Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. doi:10.2310/7750.2014.14008 PubMed
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