Biotin لـ تساقط الشعر الكربي (Telogen Effluvium)
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.بناءً على 9 دراسة (2 RCTs) بمشاركة 484 مشاركًا إجمالاً. النتائج متباينة بين الدراسات.
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B
الخلاصة
Research on biotin for telogen effluvium is mixed — it may help in some cases, especially if biotin levels are low, but it is not a reliable standalone solution for this type of hair shedding.
- Results are mixed across 9 studies — some show benefit, others do not
- Lower serum biotin levels have been observed in some telogen effluvium patients
- Biotin was often studied as part of multi-ingredient supplements, making it hard to isolate its specific effect
- Testing biotin levels before supplementing may help identify who is most likely to benefit
Key Study Findings
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
مقابل: Placebo
التأثير: None
None
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
مقابل: Placebo
التأثير: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
مقابل: Placebo
التأثير: MD=+12.3 hairs/cm2 at 6 months
p<0.05
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
مقابل: Placebo
التأثير: None
None
narrative review
Valproate-associated hair abnormalities: Pathophysiology and management strategies.
Dose: not specified
مقابل: Placebo
التأثير: None
None
case-control study
n=80
Biotin Deficiency in Telogen Effluvium: Fact or Fiction?
Dose: None
مقابل: Placebo
التأثير: None
None
Key Statistics
9
الدراسات
484
المشاركون
↔
Mixed
B
التقييم
Referenced Papers
Skin appendage disorders
2025
3 اقتباسات
Nutrients
2025
2 اقتباسات
Journal of drugs …
2025
Journal of cosmetic …
2024
7 اقتباسات
Human psychopharmacology
2022
7 اقتباسات
The Journal of …
2020
7 اقتباسات
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 اقتباسات
Journal of photochemistry …
2018
16 اقتباسات
International journal of …
2016
89 اقتباسات
Journal of cutaneous …
2014
10 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 30 mcg/day
- hairloss:
- 2,500-5,000 mcg/day
الحد الأعلى: No established UL (water-soluble)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| not applicable | -- | Mixed | 180 |
| not specified | -- | Positive | -- |
| None | -- | Neutral | 80 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| None | -- | Neutral | 144 |
أفضل وقت للتناول: With meals for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ May interfere with laboratory test results (troponin, thyroid panels)
- ⚠ Rare skin rashes at high doses
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential acne breakouts at doses above 5,000 mcg
التفاعلات المعروفة
- ● Anticonvulsants (carbamazepine, phenytoin) may reduce biotin levels
- ● Raw egg whites (avidin) bind biotin and reduce absorption
- ● Prolonged antibiotic use may deplete gut bacterial biotin synthesis
الحد الأقصى المسموح به: No established UL (water-soluble)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Biotin help with تساقط الشعر الكربي (Telogen Effluvium)?
Based on 9 studies with 484 participants, there is moderate evidence from clinical studies that Biotin may support تساقط الشعر الكربي (Telogen Effluvium) management. Our evidence grade is B (Good Evidence).
How much Biotin should I take for تساقط الشعر الكربي (Telogen Effluvium)?
Studies have used various dosages. A commonly studied range is 30 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Biotin?
Reported side effects may include May interfere with laboratory test results (troponin, thyroid panels), Rare skin rashes at high doses, Mild gastrointestinal discomfort, Potential acne breakouts at doses above 5,000 mcg. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Biotin and تساقط الشعر الكربي (Telogen Effluvium)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 484 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ تساقط الشعر الكربي (Telogen Effluvium)
Biotin لحالات أخرى
References
- [1] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [2] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [3] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [4] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
- [5] Samir Kumar Praharaj et al.. Hum Psychopharmacol. 2022. Valproate-associated hair abnormalities: Pathophysiology and management strategies. doi:10.1002/hup.2814 PubMed
- [6] Sherine Hosny Abdel Rahman et al.. J Clin Aesthet Dermatol. 2020. Biotin Deficiency in Telogen Effluvium: Fact or Fiction? PubMed
- [7] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
- [8] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [9] Ralph M Trüeb. Int J Trichology. 2016. Serum Biotin Levels in Women Complaining of Hair Loss. doi:10.4103/0974-7753.188040 PubMed
- [10] Thamer Mubki. J Cutan Med Surg. 2014. Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. doi:10.2310/7750.2014.14008 PubMed
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