비오틴 관련 휴지기 탈모증
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.총 484명의 참여자를 대상으로 한 9건의 연구(RCT 2건)에 근거합니다. 연구 결과는 혼재되어 있습니다.
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B
결론
Research on biotin for telogen effluvium is mixed — it may help in some cases, especially if biotin levels are low, but it is not a reliable standalone solution for this type of hair shedding.
- Results are mixed across 9 studies — some show benefit, others do not
- Lower serum biotin levels have been observed in some telogen effluvium patients
- Biotin was often studied as part of multi-ingredient supplements, making it hard to isolate its specific effect
- Testing biotin levels before supplementing may help identify who is most likely to benefit
Key Study Findings
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
효과: None
None
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
효과: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
효과: MD=+12.3 hairs/cm2 at 6 months
p<0.05
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
효과: None
None
narrative review
Valproate-associated hair abnormalities: Pathophysiology and management strategies.
Dose: not specified
vs: Placebo
효과: None
None
case-control study
n=80
Biotin Deficiency in Telogen Effluvium: Fact or Fiction?
Dose: None
vs: Placebo
효과: None
None
Key Statistics
9
연구
484
참여자
↔
Mixed
B
등급
Referenced Papers
Skin appendage disorders
2025
3 인용
Nutrients
2025
2 인용
Journal of drugs …
2025
Journal of cosmetic …
2024
7 인용
Human psychopharmacology
2022
7 인용
The Journal of …
2020
7 인용
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 인용
Journal of photochemistry …
2018
16 인용
International journal of …
2016
89 인용
Journal of cutaneous …
2014
10 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 30 mcg/day
- hairloss:
- 2,500-5,000 mcg/day
상한량: No established UL (water-soluble)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| not applicable | -- | Mixed | 180 |
| not specified | -- | Positive | -- |
| None | -- | Neutral | 80 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| None | -- | Neutral | 144 |
권장 복용 시간: With meals for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ May interfere with laboratory test results (troponin, thyroid panels)
- ⚠ Rare skin rashes at high doses
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential acne breakouts at doses above 5,000 mcg
알려진 상호작용
- ● Anticonvulsants (carbamazepine, phenytoin) may reduce biotin levels
- ● Raw egg whites (avidin) bind biotin and reduce absorption
- ● Prolonged antibiotic use may deplete gut bacterial biotin synthesis
일일 최대 섭취 허용량: No established UL (water-soluble)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does 비오틴 help with 휴지기 탈모증?
Based on 9 studies with 484 participants, there is moderate evidence from clinical studies that 비오틴 may support 휴지기 탈모증 management. Our evidence grade is B (Good Evidence).
How much 비오틴 should I take for 휴지기 탈모증?
Studies have used various dosages. A commonly studied range is 30 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 비오틴?
Reported side effects may include May interfere with laboratory test results (troponin, thyroid panels), Rare skin rashes at high doses, Mild gastrointestinal discomfort, Potential acne breakouts at doses above 5,000 mcg. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 비오틴 and 휴지기 탈모증?
We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 484 total participants. The overall direction of effect is mixed.
Related Evidence
비오틴 다른 건강 상태에 대한 근거
References
- [1] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [2] Andrea Sechi et al.. Nutrients. 2025. Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients. doi:10.3390/nu17091451 PubMed
- [3] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [4] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
- [5] Samir Kumar Praharaj et al.. Hum Psychopharmacol. 2022. Valproate-associated hair abnormalities: Pathophysiology and management strategies. doi:10.1002/hup.2814 PubMed
- [6] Sherine Hosny Abdel Rahman et al.. J Clin Aesthet Dermatol. 2020. Biotin Deficiency in Telogen Effluvium: Fact or Fiction? PubMed
- [7] Flávia Alvim Sant'Anna Addor et al.. Clin Cosmet Investig Dermatol. 2018. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. doi:10.2147/CCID.S173082 PubMed
- [8] Thomas Hengl et al.. J Photochem Photobiol B. 2018. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes. doi:10.1016/j.jphotobiol.2018.09.005 PubMed
- [9] Ralph M Trüeb. Int J Trichology. 2016. Serum Biotin Levels in Women Complaining of Hair Loss. doi:10.4103/0974-7753.188040 PubMed
- [10] Thamer Mubki. J Cutan Med Surg. 2014. Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia. doi:10.2310/7750.2014.14008 PubMed
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