Spironolactone pour Alopécie Androgénétique

Basé sur 25 études (4 meta-analyses, 2 RCTs) avec 6,273 participants au total. 19/25 études montrent des effets positifs.

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En conclusion

Spironolactone is well-supported by research as an anti-androgen medication that may help reduce hair loss in androgenetic alopecia, particularly in women, though it requires medical supervision.

76% of studies show positive effects, backed by 4 meta-analyses
Works by blocking androgen hormones that contribute to hair miniaturization
Particularly studied in women with PCOS-related and female pattern hair loss
Requires prescription and medical monitoring due to hormonal effects

Key Study Findings

Review

Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.

Dose: None vs: None Outcome: None Effet: None None

Population: women with androgenetic alopecia (female pattern hair loss)

Review

Male and female pattern hair loss.

Dose: None vs: Placebo Effet: None None

RCT n=48 24 weeks Double-blind

Efficacy and safety of oral spironolactone for female pattern hair loss in premenopausal women: a …

Dose: Spironolactone 100 mg once daily vs: Placebo Effet: Terminal hair counts: 9.48 vs 5.32 hairs/cm2; hair diameter: 4.23 vs 2.96 μm; moderate-to-marked imp p=0.063 (terminal hair counts)

Randomized Controlled Trial n=125 4 weeks Double-blind

Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, …

Dose: CBD 300 mg + 1 mg each of 8 terpenes vs: Placebo Outcome: Percentage of time in SWS + REM sleep Effet: 1.3% increase [0.1-2.5%]; up to 48 min/night in su 0.03

Population: Individuals with insomnia

Cohort Study n=203

An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia.

Dose: None vs: None Outcome: Clinical presentation and treatment outcomes in pediatric AGA Effet: None None

Population: Pediatric patients with androgenetic alopecia (multicenter)

Randomized Controlled Trial n=30

A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation …

Dose: None vs: Drug therapy (minoxidil + finasteride/spironolactone) only Outcome: Follicle survival rate, growth rate, hair strength Effet: None None

Population: Patients with androgenetic alopecia

Key Statistics

Études

6472

Participants

↑

Positive

Note

Referenced Papers

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A Scoping Review of Exosome Delivery Applications in Hair Loss. Review

Cureus 2025 7 citations

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A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia. RCT

Journal of cosmetic … 2025 5 citations

Efficacy and safety of oral spironolactone for female pattern hair loss in premenopausal women: a randomized, double-blind, placebo-controlled, parallel-group pilot … Other

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An international multicenter, retrospective cohort study of 203 patients with pediatric androgenetic alopecia. Other

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Evaluating the Role of the Gabrin Sign in Predicting COVID-19 Severity Among Patients with Androgenic Alopecia. Other

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The Hormonal Background of Hair Loss in Non-Scarring Alopecias. Review

Biomedicines 2024 17 citations

The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral … RCT

Journal of cosmetic … 2024 14 citations

Management of androgenic alopecia: a systematic review of the literature. Systematic Review

Journal of cosmetic … 2024 11 citations

Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies. Review

Journal of clinical … 2024 11 citations

Cannabidiol (CBD) Inhibits Foam Cell Formation via Regulating Cholesterol Homeostasis and Lipid Metabolism. Other

Molecular nutrition & … 2024 5 citations

Comparative analysis of low-dose oral minoxidil with spironolactone versus finasteride or dutasteride in female androgenetic alopecia management. Other

Archives of dermatological … 2024 4 citations

Improving efficacy and maintaining safety in the treatment of alopecia with low-dose oral minoxidil and spironolactone combination therapy: A retrospective … Other

JAAD international 2024 1 citations

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JAAD international 2023 80 citations

Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs. Review

Clinical, cosmetic and … 2023 58 citations

The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review. Review

Clinical, cosmetic and … 2023 25 citations

Androgenetic alopecia in transgender and gender diverse populations: A review of therapeutics. Review

Journal of the … 2023 24 citations

Medical and procedural treatment of androgenetic alopecia - Where are we? Review

Journal of the … 2023 20 citations

The Efficacy and Safety of Oral Spironolactone in the Treatment of Female Pattern Hair Loss: A Systematic Review and Meta-Analysis. Review

Cureus 2023 13 citations

Efficacy and safety profile of oral spironolactone use for androgenic alopecia: A systematic review. Systematic Review

Journal of the … 2022 24 citations

Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: … Case Report

Frontiers in medicine 2022 14 citations

Primary care provider attitudes, experiences and practices about cannabidiol (CBD) and barriers to patient-provider communication about CBD use: A qualitative … Other

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Current pain and … 2020 85 citations

Spironolactone use does not increase the risk of female breast cancer recurrence: A retrospective analysis. Other

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Herbal Medicines For Treatment of Androgenic Alopecia. Review

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Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee. Meta-Analysis

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Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review. Review

International journal of … 2018 129 citations

Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2017: A Cross-Sectional Study. Other

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Androgenic alopecia: an entity to consider in adolescence. Case Report

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Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

hairloss:: 100-200 mg/day (prescription)

Limite supérieure : 200 mg/day (hair loss indication)

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Neutral	--
None	--	Positive	--
Spironolactone 100 mg once daily	24 weeks	Positive	48
CBD 300 mg + 1 mg each of 8 terpenes	4 weeks	Positive	125
None	--	Positive	203
None	--	Positive	30
various across included studies (2015-2024)	--	Positive	--
None	--	Mixed	--

Moment optimal de prise : Once or twice daily with food; prescription required

Safety & Side Effects

Effets indésirables signalés

⚠ Menstrual irregularities
⚠ Breast tenderness
⚠ Hyperkalemia (elevated potassium levels)
⚠ Dizziness and orthostatic hypotension
⚠ Frequent urination

Interactions connues

● ACE inhibitors and ARBs (increased hyperkalemia risk)
● Potassium supplements and potassium-sparing diuretics (dangerous hyperkalemia)
● NSAIDs (may reduce diuretic effectiveness and increase kidney risk)
● Digoxin (spironolactone may increase digoxin levels)

Apport maximal tolérable : 200 mg/day (hair loss indication)

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Spironolactone help with Alopécie Androgénétique?

Based on 45 studies with 6,472 participants, there is strong evidence from multiple clinical trials that Spironolactone may support Alopécie Androgénétique management. Our evidence grade is A (Strong Evidence).

How much Spironolactone should I take for Alopécie Androgénétique?

Studies have used various dosages. A commonly studied range is 100-200 mg/day (prescription). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Spironolactone?

Reported side effects may include Menstrual irregularities, Breast tenderness, Hyperkalemia (elevated potassium levels), Dizziness and orthostatic hypotension. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Spironolactone and Alopécie Androgénétique?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 45 peer-reviewed studies with 6,472 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Alopécie Androgénétique

Minoxidil A Finasteride A Thérapie PRP A Dutasteride A Acides gras oméga-3 A Micro-aiguilles A

Spironolactone pour d'autres pathologies

Perte Capillaire Féminine A

Verdict rapide

Basé sur 25 études (4 meta-analyses, 2 RCTs) avec 6,273 participants au total. 19/25 études montrent des effets positifs.

Evidence Strength92%

High confidence

Synthèse des études

RCT (4)Meta (2)Other (39)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Alopécie Androgénétique

En savoir plus

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.