维生素 B12 用于营养缺乏性脱发

Q: Does 维生素 B12 help with 营养缺乏性脱发?

Based on 19 studies with 8,130 participants, there is insufficient evidence at this time that 维生素 B12 may support 营养缺乏性脱发 management. Our evidence grade is F (Evidence Against).

Q: How much 维生素 B12 should I take for 营养缺乏性脱发?

Studies have used various dosages. A commonly studied range is 2.4 mcg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of 维生素 B12?

Reported side effects may include Generally well tolerated even at high doses, Rare allergic reactions (itching, swelling), Mild diarrhea or nausea at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for 维生素 B12 and 营养缺乏性脱发?

We rate the evidence as Grade F (Evidence Against). This rating is based on 19 peer-reviewed studies with 8,130 total participants. The overall direction of effect is mixed.

F 效果研究表明，该用途可能不太有效。

基于20项研究，共8,355名参与者。各研究结果不一。

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结论

Research shows mixed results for vitamin B12 and hair loss — while deficiency may contribute to hair thinning, supplementation is unlikely to help unless you have a confirmed B12 deficiency.

Mixed results across 20 studies — no consistent benefit from supplementation
Some studies find lower B12 levels in hair loss patients, others do not
No large-scale RCTs testing B12 supplementation specifically for hair regrowth
Supplementation may only help if a genuine B12 deficiency is present

Key Study Findings

retrospective observational n=113

Telogen Effluvium Following Coronavirus Disease-2019 Infection: A Retrospective Study of 113 Cases.

Dose: None vs: Placebo 效果: None None

Retrospective cohort n=2851

Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.

Dose: None vs: Placebo 效果: Ferritin low in 46.5% of patients; iron deficiency in 29.5% p<0.05

Review

Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Review of pharmacogenomics of THC and CBD

case-control study n=180

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …

Dose: not applicable vs: Placebo 效果: None None

Cross-Sectional Study n=108

Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with …

Dose: None vs: Placebo 效果: None 0.05

Case-control n=973

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …

Dose: None vs: Placebo 效果: r=0.417 (HGB and AHR in females) p=0.008

Key Statistics

研究数量

8130

受试者

↔

Mixed

等级

Referenced Papers

Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. Other

Journal of cosmetic … 2025 4 次引用

Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. Review

Genes 2025 1 次引用

Telogen Effluvium Following Coronavirus Disease-2019 Infection: A Retrospective Study of 113 Cases. Other

International journal of … 2025

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … Other

Journal of cosmetic … 2024 7 次引用

Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin … Other

Northern clinics of … 2024 1 次引用

Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US. Other

JAMA 2023 49 次引用

Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. Other

Dermatology practical & … 2023 4 次引用

Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial. Other

Sports medicine - … 2022 34 次引用

Differentiating Cannabis Products: Drugs, Food, and Supplements. Review

Frontiers in pharmacology 2022 31 次引用

Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. Other

Journal of cosmetic … 2022 22 次引用

Nonscarring scalp alopecia: Which laboratory analysis should we perform on whom? Other

Turkish journal of … 2022 8 次引用

CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons. Other

Journal of pain … 2020 56 次引用

NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. Observational

Journal of cosmetic … 2019 25 次引用

The Role of Micronutrients in Alopecia Areata: A Review. Review

American journal of … 2017 104 次引用

Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. Other

Journal of drugs … 2016 56 次引用

Clinicoepidemiological Observational Study of Acquired Alopecias in Females Correlating with Anemia and Thyroid Function. Other

Dermatology research and … 2016 26 次引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 次引用

Vitamin B12 and omega-3 fatty acids together regulate lipid metabolism in Wistar rats. Other

Prostaglandins, leukotrienes, and … 2015 40 次引用

The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … Other

Clinical and experimental … 2009 34 次引用

Management of hair loss in women. Review

Dermatologic clinics 1993 38 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 2.4 mcg/day
deficiency:: 1,000-2,000 mcg/day

上限： No established UL

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Neutral	113
None	--	Neutral	2851
None	--	Mixed	--
not applicable	--	Mixed	180
None	--	Mixed	108
None	--	Positive	973
None	--	Neutral	--
300 mg single dose	--	Mixed	9

最佳服用时间： With meals; sublingual form can be taken any time

Safety & Side Effects

已报告的副作用

⚠ Generally well tolerated even at high doses
⚠ Rare allergic reactions (itching, swelling)
⚠ Mild diarrhea or nausea at very high doses

已知相互作用

● Metformin (reduces B12 absorption by 10-30%)
● Proton pump inhibitors and H2 blockers (reduce B12 absorption)
● Colchicine (may reduce B12 absorption)

可耐受最高摄入量： No established UL

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 维生素 B12 help with 营养缺乏性脱发?

Based on 19 studies with 8,130 participants, there is insufficient evidence at this time that 维生素 B12 may support 营养缺乏性脱发 management. Our evidence grade is F (Evidence Against).

How much 维生素 B12 should I take for 营养缺乏性脱发?

Studies have used various dosages. A commonly studied range is 2.4 mcg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 维生素 B12?

Reported side effects may include Generally well tolerated even at high doses, Rare allergic reactions (itching, swelling), Mild diarrhea or nausea at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 维生素 B12 and 营养缺乏性脱发?

We rate the evidence as Grade F (Evidence Against). This rating is based on 19 peer-reviewed studies with 8,130 total participants. The overall direction of effect is mixed.

其他成分用于营养缺乏性脱发

硒 A 生物素（Biotin） B Vitamin A D L-半胱氨酸 D 叶酸（Folate） F

维生素 B12 用于其他健康状况

休止期脱发 F

快速结论

基于20项研究，共8,355名参与者。各研究结果不一。

Evidence Strength10%

Low confidence

研究分析

RCT (0)Meta (0)Other (19)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于营养缺乏性脱发

了解更多

References

[1] Ömer Karakoyun et al.. J Cosmet Dermatol. 2025. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience. doi:10.1111/jocd.70037 PubMed
[2] Małgorzata Kalak et al.. Genes (Basel). 2025. Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. doi:10.3390/genes16121487 PubMed
[3] Namrata Chhabra et al.. Int J Trichology. 2025. Telogen Effluvium Following Coronavirus Disease-2019 Infection: A Retrospective Study of 113 Cases. doi:10.4103/ijt.ijt_38_22 PubMed
[4] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
[5] Leyla Bilik et al.. North Clin Istanb. 2024. Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin … doi:10.14744/nci.2023.33269 PubMed
[6] Pieter A Cohen et al.. JAMA. 2023. Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US. doi:10.1001/jama.2023.2296 PubMed
[7] Hakan Arslan et al.. Dermatol Pract Concept. 2023. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center. doi:10.5826/dpc.1303a202 PubMed
[8] Ayshe Sahinovic et al.. Sports Med Open. 2022. Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial. doi:10.1186/s40798-022-00417-y PubMed
[9] Arash Salehi et al.. Front Pharmacol. 2022. Differentiating Cannabis Products: Drugs, Food, and Supplements. doi:10.3389/fphar.2022.906038 PubMed
[10] Ahu Yorulmaz et al.. J Cosmet Dermatol. 2022. Telogen effluvium in daily practice: Patient characteristics, laboratory parameters, and treatment modalities of 3028 patients with telogen effluvium. doi:10.1111/jocd.14413 PubMed
[11] Ümran Öner et al.. Turk J Med Sci. 2022. Nonscarring scalp alopecia: Which laboratory analysis should we perform on whom? doi:10.3906/sag-2106-28 PubMed
[12] Uma Anand et al.. J Pain Res. 2020. CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons. doi:10.2147/JPR.S258433 PubMed
[13] Kavita Poonia et al.. J Cosmet Dermatol. 2019. NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. doi:10.1111/jocd.12559 PubMed
[14] Jordan M Thompson et al.. Am J Clin Dermatol. 2017. The Role of Micronutrients in Alopecia Areata: A Review. doi:10.1007/s40257-017-0285-x PubMed
[15] Evelyn J Cheung et al.. J Drugs Dermatol. 2016. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study. PubMed
[16] Kirti Deo et al.. Dermatol Res Pract. 2016. Clinicoepidemiological Observational Study of Acquired Alopecias in Females Correlating with Anemia and Thyroid Function. doi:10.1155/2016/6279108 PubMed
[17] Jana Zímová et al.. Acta Dermatovenerol Croat. 2016. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. PubMed
[18] Amrita Khaire et al.. Prostaglandins Leukot Essent Fatty Acids. 2015. Vitamin B12 and omega-3 fatty acids together regulate lipid metabolism in Wistar rats. doi:10.1016/j.plefa.2015.04.006 PubMed
[19] C Durusoy et al.. Clin Exp Dermatol. 2009. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control … doi:10.1111/j.1365-2230.2008.03165.x PubMed
[20] D H Rushton. Dermatol Clin. 1993. Management of hair loss in women. PubMed

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维生素 B12 用于 营养缺乏性脱发