硒 用于 营养缺乏性脱发
A 证据 多项大型临床试验一致显示出显著的益处。基于35项研究（6项荟萃分析、5项RCT），共10,466名参与者。各研究结果不一。
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A
结论
Research does not support selenium supplementation for hair loss — in fact, excessive selenium intake has been associated with hair loss, so supplementation without a confirmed deficiency is not recommended.
- Mixed results across 35 studies — no clear benefit for hair loss
- Both selenium deficiency and excess may contribute to hair problems
- Case reports have linked selenium supplements to hair loss and nail damage
- Only supplement if a healthcare provider has confirmed a deficiency
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
效果: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
研究人群: Elderly participants aged 60+ from NHANES 2011-2014
Systematic Review and Meta-Analysis
n=7014
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Dose: None
vs: Placebo
效果: Standardized mean differences reported for each element and disease combination (specific values not
None
prospective controlled study
n=30
Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …
Dose: None
vs: Placebo
效果: None
None
Review
The role of trace elements for the function and health of the skin.
Dose: None
vs: Placebo
效果: None
None
Review
Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of pharmacogenomics of THC and CBD
Review
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Dose: None
vs: Placebo
效果: None
None
Key Statistics
38
研究数量
10748
受试者
↔
Mixed
A
等级
Referenced Papers
Brain and behavior
2026
Redox report : …
2025
8 次引用
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Review
Current medicinal chemistry
2025
5 次引用
Journal of trace …
2025
4 次引用
Cutaneous and ocular …
2025
1 次引用
Genes
2025
1 次引用
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Meta-Analysis
Nutrition reviews
2025
Journal of cosmetic …
2024
7 次引用
Micronutrients and Androgenetic Alopecia: A Systematic Review.
Systematic Review
Molecular nutrition & …
2024
7 次引用
Journal of cosmetic …
2024
4 次引用
The Cochrane database …
2023
47 次引用
Arthritis care & …
2023
36 次引用
Frontiers in pharmacology
2023
29 次引用
Journal of the …
2023
20 次引用
Bartter Syndrome: A Systematic Review of Case Reports and Case Series.
Systematic Review
Medicina (Kaunas, Lithuania)
2023
17 次引用
Molecules (Basel, Switzerland)
2023
14 次引用
Skin research and …
2023
11 次引用
Medical cannabis and …
2023
9 次引用
Safety and risks of CBD oils purchased online: unveiling uncertain quality and vague health claims.
Other
Frontiers in pharmacology
2023
8 次引用
Italian journal of …
2023
3 次引用
Journal of equine …
2022
6 次引用
Therapeutic advances in …
2022
4 次引用
Cannabis and cannabinoid …
2021
171 次引用
The Journal of …
2021
162 次引用
Journal of clinical …
2020
42 次引用
Skin appendage disorders
2020
10 次引用
Medical cannabis and …
2018
158 次引用
Journal of dance …
2018
15 次引用
American journal of …
2017
104 次引用
Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
Meta-Analysis
The Journal of …
2017
31 次引用
Acta dermatovenerologica Croatica …
2016
6 次引用
Prostaglandins, leukotrienes, and …
2015
40 次引用
[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].
Review
Der Internist
2015
3 次引用
Inflammatory bowel diseases
2012
224 次引用
Medycyna wieku rozwojowego
2011
Food and nutrition …
2008
83 次引用
The New England …
2006
47 次引用
Cardiovascular research
2006
42 次引用
Acta dermato-venereologica
1986
53 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 55 mcg/day
上限： 400 mcg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Mixed | 7014 |
| None | -- | Neutral | 30 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| NaSe 5.6ppm, Met 4.7ppm, DPDS 14.2ppm, NanoSe 2.7ppm | 4 weeks | Positive | 40 |
| not applicable | -- | Mixed | 180 |
最佳服用时间： With meals for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hair loss at excessive doses (selenosis)
- ⚠ Brittle nails
- ⚠ Garlic-like breath odor at high doses
- ⚠ Nausea and diarrhea
已知相互作用
- ● Statins (selenium may reduce statin effectiveness)
- ● Chemotherapy drugs (antioxidant effects may theoretically interfere)
- ● Niacin (may decrease HDL-raising effect when combined)
可耐受最高摄入量： 400 mcg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 硒 help with 营养缺乏性脱发?
Based on 38 studies with 10,748 participants, there is strong evidence from multiple clinical trials that 硒 may support 营养缺乏性脱发 management. Our evidence grade is A (Strong Evidence).
How much 硒 should I take for 营养缺乏性脱发?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 硒?
Reported side effects may include Hair loss at excessive doses (selenosis), Brittle nails, Garlic-like breath odor at high doses, Nausea and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 硒 and 营养缺乏性脱发?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 38 peer-reviewed studies with 10,748 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 营养缺乏性脱发
硒 用于其他健康状况
References
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