维生素 B12 用于 营养缺乏性脱发
F基于20项研究，共8,355名参与者。各研究结果不一。
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F
结论
Research shows mixed results for vitamin B12 and hair loss — while deficiency may contribute to hair thinning, supplementation is unlikely to help unless you have a confirmed B12 deficiency.
- Mixed results across 20 studies — no consistent benefit from supplementation
- Some studies find lower B12 levels in hair loss patients, others do not
- No large-scale RCTs testing B12 supplementation specifically for hair regrowth
- Supplementation may only help if a genuine B12 deficiency is present
Key Study Findings
retrospective observational
n=113
Telogen Effluvium Following Coronavirus Disease-2019 Infection: A Retrospective Study of 113 Cases.
Dose: None
vs: Placebo
效果: None
None
Retrospective cohort
n=2851
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Dose: None
vs: Placebo
效果: Ferritin low in 46.5% of patients; iron deficiency in 29.5%
p<0.05
Review
Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of pharmacogenomics of THC and CBD
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
效果: None
None
Cross-Sectional Study
n=108
Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with …
Dose: None
vs: Placebo
效果: None
0.05
Case-control
n=973
Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in …
Dose: None
vs: Placebo
效果: r=0.417 (HGB and AHR in females)
p=0.008
Key Statistics
19
研究数量
8130
受试者
↔
Mixed
F
等级
Referenced Papers
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
Other
Journal of cosmetic …
2025
4 次引用
Genes
2025
1 次引用
Telogen Effluvium Following Coronavirus Disease-2019 Infection: A Retrospective Study of 113 Cases.
Other
International journal of …
2025
Journal of cosmetic …
2024
7 次引用
Northern clinics of …
2024
1 次引用
JAMA
2023
49 次引用
Dermatology practical & …
2023
4 次引用
Sports medicine - …
2022
34 次引用
Frontiers in pharmacology
2022
31 次引用
Journal of cosmetic …
2022
22 次引用
Turkish journal of …
2022
8 次引用
Journal of pain …
2020
56 次引用
NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India.
Observational
Journal of cosmetic …
2019
25 次引用
American journal of …
2017
104 次引用
Journal of drugs …
2016
56 次引用
Dermatology research and …
2016
26 次引用
Acta dermatovenerologica Croatica …
2016
6 次引用
Prostaglandins, leukotrienes, and …
2015
40 次引用
Clinical and experimental …
2009
34 次引用
Dermatologic clinics
1993
38 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 2.4 mcg/day
- deficiency:
- 1,000-2,000 mcg/day
上限： No established UL
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Neutral | 113 |
| None | -- | Neutral | 2851 |
| None | -- | Mixed | -- |
| not applicable | -- | Mixed | 180 |
| None | -- | Mixed | 108 |
| None | -- | Positive | 973 |
| None | -- | Neutral | -- |
| 300 mg single dose | -- | Mixed | 9 |
最佳服用时间： With meals; sublingual form can be taken any time
Safety & Side Effects
已报告的副作用
- ⚠ Generally well tolerated even at high doses
- ⚠ Rare allergic reactions (itching, swelling)
- ⚠ Mild diarrhea or nausea at very high doses
已知相互作用
- ● Metformin (reduces B12 absorption by 10-30%)
- ● Proton pump inhibitors and H2 blockers (reduce B12 absorption)
- ● Colchicine (may reduce B12 absorption)
可耐受最高摄入量： No established UL
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 维生素 B12 help with 营养缺乏性脱发?
Based on 19 studies with 8,130 participants, there is insufficient evidence at this time that 维生素 B12 may support 营养缺乏性脱发 management. Our evidence grade is F (Evidence Against).
How much 维生素 B12 should I take for 营养缺乏性脱发?
Studies have used various dosages. A commonly studied range is 2.4 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 维生素 B12?
Reported side effects may include Generally well tolerated even at high doses, Rare allergic reactions (itching, swelling), Mild diarrhea or nausea at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 维生素 B12 and 营养缺乏性脱发?
We rate the evidence as Grade F (Evidence Against). This rating is based on 19 peer-reviewed studies with 8,130 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 营养缺乏性脱发
维生素 B12 用于其他健康状况
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