カフェイン（外用） ： 男性型・女性型脱毛症（AGA）
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。合計62名の参加者を対象とした9件の研究（RCT 1件を含む）に基づく。9件中8件の研究で肯定的な効果が示されている。
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B
結論
Topical caffeine shows promising early evidence for supporting hair growth in androgenetic alopecia, but the research base is still small and more large-scale human trials are needed.
- 8 out of 9 studies report positive effects on hair growth
- Caffeine may work by counteracting DHT's negative effects on hair follicles
- One RCT showed improved hair density with a caffeine-containing topical product
- The total participant pool is very small (62 people), limiting the strength of conclusions
Key Study Findings
review
Single-blind
Do Non-Prescription Products Help in Managing Androgenic Alopecia?
Dose: Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed
vs: Placebo
効果: Considerable improvements in one or more parameters across 13 included studies
None
Review
A Canadian Consensus on Androgenetic Alopecia: Approach and Management.
Dose: None
vs: Placebo
効果: None
None
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
効果: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
review
[Nutrition in improving sleep quality and fighting insomnia].
Dose: tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral
vs: Placebo
効果: None
None
review
Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia.
Dose: various CAMs: pumpkin seed oil, saw palmetto, melatonin extract, caffeine extract, rosemary oil
vs: Placebo
効果: several CAMs effective vs baseline or minoxidil with minimal side effects
None
animal experimental study
Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.
Dose: dose-dependent (specific doses not reported in abstract)
vs: Placebo
効果: None
None
Key Statistics
9
研究数
62
参加者数
↑
Positive
B
グレード
Referenced Papers
Journal of cutaneous …
2025
2 件の引用
Skin appendage disorders
2025
1 件の引用
International journal of …
2025
Nutricion hospitalaria
2025
Proceedings (Baylor University. …
2024
14 件の引用
Journal of food …
2023
17 件の引用
Dermatologic therapy
2022
41 件の引用
Journal of cosmetic …
2022
11 件の引用
Journal of drugs …
2014
26 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- topical:
- 0.2% caffeine shampoo or serum
上限量： Topical only
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed | -- | Positive | -- |
| None | -- | Positive | -- |
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| tryptophan, carbohydrates, omega-3, vitamins (B6, B12, folate, niacin, D, C, beta-carotene), mineral | -- | Positive | -- |
| various CAMs: pumpkin seed oil, saw palmetto, melatonin extract, caffeine extract, rosemary oil | -- | Positive | -- |
| dose-dependent (specific doses not reported in abstract) | -- | Positive | -- |
| None | -- | Positive | -- |
| foam applied twice daily containing nicotinic acid hexyl ester, polyphenols, zinc, glycine, and caff | 26 weeks | Positive | 62 |
推奨摂取タイミング： Apply shampoo or serum to scalp, leave on for 2 minutes before rinsing
Safety & Side Effects
報告されている副作用
- ⚠ Scalp irritation or dryness
- ⚠ Minimal systemic absorption (low risk of systemic effects)
- ⚠ Contact sensitization (rare)
既知の相互作用
- ● Minoxidil (may be used in combination; no significant interaction)
- ● Other topical scalp products (apply at separate times)
耐容上限摂取量： Topical only
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does カフェイン（外用） help with 男性型・女性型脱毛症（AGA）?
Based on 9 studies with 62 participants, there is moderate evidence from clinical studies that カフェイン（外用） may support 男性型・女性型脱毛症（AGA） management. Our evidence grade is B (Good Evidence).
How much カフェイン（外用） should I take for 男性型・女性型脱毛症（AGA）?
Studies have used various dosages. A commonly studied range is 0.2% caffeine shampoo or serum. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of カフェイン（外用）?
Reported side effects may include Scalp irritation or dryness, Minimal systemic absorption (low risk of systemic effects), Contact sensitization (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for カフェイン（外用） and 男性型・女性型脱毛症（AGA）?
We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 62 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] Ian Landells et al.. J Cutan Med Surg. 2025. A Canadian Consensus on Androgenetic Alopecia: Approach and Management. doi:10.1177/12034754251368849 PubMed
- [2] Aditya K Gupta et al.. Skin Appendage Disord. 2025. Do Non-Prescription Products Help in Managing Androgenic Alopecia? doi:10.1159/000542880 PubMed
- [3] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [4] Rosa M Ortega et al.. Nutr Hosp. 2025. [Nutrition in improving sleep quality and fighting insomnia]. doi:10.20960/nh.06090 PubMed
- [5] Promise Ufomadu. Proc (Bayl Univ Med Cent). 2024. Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia. doi:10.1080/08998280.2023.2263829 PubMed
- [6] Chun Woong Park et al.. J Food Drug Anal. 2023. Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors. doi:10.38212/2224-6614.3456 PubMed
- [7] Aditya K Gupta et al.. Dermatol Ther. 2022. Natural products for male androgenetic alopecia. doi:10.1111/dth.15323 PubMed
- [8] Julia Welzel et al.. J Cosmet Dermatol. 2022. Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, … doi:10.1111/jocd.14158 PubMed
- [9] Shannon Famenini et al.. J Drugs Dermatol. 2014. Evidence for supplemental treatments in androgenetic alopecia. PubMed
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