ビオチン ： 休止期脱毛症
B合計484名の参加者を対象とした9件の研究（RCT 2件を含む）に基づく。研究間で結果にばらつきが見られる。
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B
結論
Research on biotin for telogen effluvium is mixed — it may help in some cases, especially if biotin levels are low, but it is not a reliable standalone solution for this type of hair shedding.
- Results are mixed across 9 studies — some show benefit, others do not
- Lower serum biotin levels have been observed in some telogen effluvium patients
- Biotin was often studied as part of multi-ingredient supplements, making it hard to isolate its specific effect
- Testing biotin levels before supplementing may help identify who is most likely to benefit
Key Study Findings
Review
Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients.
Dose: None
vs: Placebo
効果: None
None
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
効果: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
効果: MD=+12.3 hairs/cm2 at 6 months
p<0.05
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
効果: None
None
narrative review
Valproate-associated hair abnormalities: Pathophysiology and management strategies.
Dose: not specified
vs: Placebo
効果: None
None
case-control study
n=80
Biotin Deficiency in Telogen Effluvium: Fact or Fiction?
Dose: None
vs: Placebo
効果: None
None
Key Statistics
9
研究数
484
参加者数
↔
Mixed
B
グレード
Referenced Papers
Skin appendage disorders
2025
3 件の引用
Nutrients
2025
2 件の引用
Journal of drugs …
2025
Journal of cosmetic …
2024
7 件の引用
Human psychopharmacology
2022
7 件の引用
The Journal of …
2020
7 件の引用
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Other
Clinical, cosmetic and …
2018
16 件の引用
Journal of photochemistry …
2018
16 件の引用
International journal of …
2016
89 件の引用
Journal of cutaneous …
2014
10 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 30 mcg/day
- hairloss:
- 2,500-5,000 mcg/day
上限量： No established UL (water-soluble)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| not applicable | -- | Mixed | 180 |
| not specified | -- | Positive | -- |
| None | -- | Neutral | 80 |
| recommended daily intake amounts; taken orally for 180 days | 26 weeks | Positive | -- |
| None | -- | Neutral | 144 |
推奨摂取タイミング： With meals for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ May interfere with laboratory test results (troponin, thyroid panels)
- ⚠ Rare skin rashes at high doses
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential acne breakouts at doses above 5,000 mcg
既知の相互作用
- ● Anticonvulsants (carbamazepine, phenytoin) may reduce biotin levels
- ● Raw egg whites (avidin) bind biotin and reduce absorption
- ● Prolonged antibiotic use may deplete gut bacterial biotin synthesis
耐容上限摂取量： No established UL (water-soluble)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does ビオチン help with 休止期脱毛症?
Based on 9 studies with 484 participants, there is moderate evidence from clinical studies that ビオチン may support 休止期脱毛症 management. Our evidence grade is B (Good Evidence).
How much ビオチン should I take for 休止期脱毛症?
Studies have used various dosages. A commonly studied range is 30 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of ビオチン?
Reported side effects may include May interfere with laboratory test results (troponin, thyroid panels), Rare skin rashes at high doses, Mild gastrointestinal discomfort, Potential acne breakouts at doses above 5,000 mcg. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for ビオチン and 休止期脱毛症?
We rate the evidence as Grade B (Good Evidence). This rating is based on 9 peer-reviewed studies with 484 total participants. The overall direction of effect is mixed.
Related Evidence
ビオチン 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。