Olio di semi di zucca per Alopecia androgenetica
A Evidenze Più grandi trial clinici mostrano in modo costante benefici significativi.Basato su 14 studi (2 meta-analyses, 3 RCTs) con 1,874 partecipanti totali. 13/14 studi mostrano effetti positivi.
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A
In sintesi
Pumpkin seed oil is well-supported by multiple clinical trials as a natural supplement that may help promote hair growth in androgenetic alopecia through its DHT-blocking properties.
- 13 out of 14 studies show positive effects, including 3 RCTs
- Acts as a natural 5-alpha reductase inhibitor, potentially reducing DHT levels
- Both oral supplementation and topical application have been studied
- One RCT showed comparable results to minoxidil 5% in women
Key Study Findings
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
Effetto: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
Effetto: MD=+12.3 hairs/cm2 at 6 months
p<0.05
narrative review
Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.
Dose: varies by remedy and study
vs: Placebo
Effetto: None
None
systematic review
n=1658
Double-blind
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Dose: various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami
vs: Placebo
Effetto: None
None
review
Single-blind
Do Non-Prescription Products Help in Managing Androgenic Alopecia?
Dose: Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed
vs: Placebo
Effetto: Considerable improvements in one or more parameters across 13 included studies
None
review
Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia.
Dose: finasteride 1 mg/day; dutasteride 0.5 mg/day; various natural product doses
vs: Placebo
Effetto: None
None
Key Statistics
15
Studi
1874
Partecipanti
↑
Positive
A
Grado
Referenced Papers
Skin appendage disorders
2025
7 citazioni
Skin appendage disorders
2025
3 citazioni
Journal of cosmetic …
2025
1 citazioni
Skin appendage disorders
2025
1 citazioni
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Systematic Review
Frontiers in nutrition
2025
Journal of drugs …
2025
Proceedings (Baylor University. …
2024
14 citazioni
Expert opinion on …
2024
8 citazioni
Clinical, cosmetic and …
2024
7 citazioni
Dermatologic therapy
2022
41 citazioni
Journal of cosmetic …
2021
29 citazioni
Archives of dermatological …
2020
51 citazioni
The Journal of …
2020
24 citazioni
Journal of cosmetic …
2019
100 citazioni
Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.
Other
Avicenna journal of …
2019
23 citazioni
Evidence-based complementary and …
2015
4 citazioni
Evidence-based complementary and …
2014
86 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- hairloss:
- 400 mg/day
Limite massimo: Not established
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| varies by remedy and study | -- | Positive | -- |
| various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami | -- | Positive | 1658 |
| Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed | -- | Positive | -- |
| finasteride 1 mg/day; dutasteride 0.5 mg/day; various natural product doses | -- | Positive | -- |
| various CAMs: pumpkin seed oil, saw palmetto, melatonin extract, caffeine extract, rosemary oil | -- | Positive | -- |
| not specified | -- | Positive | -- |
Momento migliore per l'assunzione: With meals for better absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Mild gastrointestinal upset
- ⚠ Possible stomach discomfort at high doses
- ⚠ Rare allergic reactions in individuals with cucurbit allergies
Interazioni note
- ● Anticoagulants (theoretical increased bleeding risk)
- ● Lithium (pumpkin seed oil may have diuretic properties)
Livello di assunzione massimo tollerabile: Not established
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Olio di semi di zucca help with Alopecia androgenetica?
Based on 15 studies with 1,874 participants, there is strong evidence from multiple clinical trials that Olio di semi di zucca may support Alopecia androgenetica management. Our evidence grade is A (Strong Evidence).
How much Olio di semi di zucca should I take for Alopecia androgenetica?
Studies have used various dosages. A commonly studied range is 400 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Olio di semi di zucca?
Reported side effects may include Mild gastrointestinal upset, Possible stomach discomfort at high doses, Rare allergic reactions in individuals with cucurbit allergies. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Olio di semi di zucca and Alopecia androgenetica?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,874 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Alopecia androgenetica
References
- [1] Azhar Ahmed et al.. Skin Appendage Disord. 2025. Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. doi:10.1159/000542876 PubMed
- [2] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [3] Massimo Milani et al.. J Cosmet Dermatol. 2025. Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real-Life, Multicenter, Randomized, Assessor-Blinded Trial … doi:10.1111/jocd.70388 PubMed
- [4] Aditya K Gupta et al.. Skin Appendage Disord. 2025. Do Non-Prescription Products Help in Managing Androgenic Alopecia? doi:10.1159/000542880 PubMed
- [5] Lei Zhou et al.. Front Nutr. 2025. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. doi:10.3389/fnut.2025.1719711 PubMed
- [6] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [7] Promise Ufomadu. Proc (Bayl Univ Med Cent). 2024. Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia. doi:10.1080/08998280.2023.2263829 PubMed
- [8] Aditya K Gupta et al.. Expert Opin Emerg Drugs. 2024. Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia. doi:10.1080/14728214.2024.2346590 PubMed
- [9] Nouf F Bin Rubaian et al.. Clin Cosmet Investig Dermatol. 2024. An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, with Special Emphasis on Rosemary Oil. doi:10.2147/CCID.S470989 PubMed
- [10] Aditya K Gupta et al.. Dermatol Ther. 2022. Natural products for male androgenetic alopecia. doi:10.1111/dth.15323 PubMed
- [11] Ibrahim M Ibrahim et al.. J Cosmet Dermatol. 2021. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. doi:10.1111/jocd.13976 PubMed
- [12] Ana Zgonc Škulj et al.. Arch Dermatol Res. 2020. Herbal preparations for the treatment of hair loss. doi:10.1007/s00403-019-02003-x PubMed
- [13] Nneamaka Ezekwe et al.. J Clin Aesthet Dermatol. 2020. The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic … PubMed
- [14] Maria Yusuf Dhariwala et al.. J Cosmet Dermatol. 2019. An overview of herbal alternatives in androgenetic alopecia. doi:10.1111/jocd.12930 PubMed
- [15] Valiollah Hajhashemi et al.. Avicenna J Phytomed. 2019. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. doi:10.22038/AJP.2019.13463 PubMed
- [16] Hitesh Verma. Evid Based Complement Alternat Med. 2015. Comment on "effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial". doi:10.1155/2015/271474 PubMed
- [17] Young Hye Cho et al.. Evid Based Complement Alternat Med. 2014. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. doi:10.1155/2014/549721 PubMed
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