Aceite de Semilla de Calabaza para Alopecia Androgenética
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.Basado en 14 estudios (2 meta-analyses, 3 RCTs) con 1,874 participantes en total. 13/14 estudios muestran efectos positivos.
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A
Conclusión
Pumpkin seed oil is well-supported by multiple clinical trials as a natural supplement that may help promote hair growth in androgenetic alopecia through its DHT-blocking properties.
- 13 out of 14 studies show positive effects, including 3 RCTs
- Acts as a natural 5-alpha reductase inhibitor, potentially reducing DHT levels
- Both oral supplementation and topical application have been studied
- One RCT showed comparable results to minoxidil 5% in women
Key Study Findings
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
Efecto: None
None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
Efecto: MD=+12.3 hairs/cm2 at 6 months
p<0.05
narrative review
Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.
Dose: varies by remedy and study
vs: Placebo
Efecto: None
None
systematic review
n=1658
Double-blind
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Dose: various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami
vs: Placebo
Efecto: None
None
review
Single-blind
Do Non-Prescription Products Help in Managing Androgenic Alopecia?
Dose: Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed
vs: Placebo
Efecto: Considerable improvements in one or more parameters across 13 included studies
None
review
Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia.
Dose: finasteride 1 mg/day; dutasteride 0.5 mg/day; various natural product doses
vs: Placebo
Efecto: None
None
Key Statistics
15
Estudios
1874
Participantes
↑
Positive
A
Calificación
Referenced Papers
Skin appendage disorders
2025
7 citas
Skin appendage disorders
2025
3 citas
Journal of cosmetic …
2025
1 citas
Skin appendage disorders
2025
1 citas
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Systematic Review
Frontiers in nutrition
2025
Journal of drugs …
2025
Proceedings (Baylor University. …
2024
14 citas
Expert opinion on …
2024
8 citas
Clinical, cosmetic and …
2024
7 citas
Dermatologic therapy
2022
41 citas
Journal of cosmetic …
2021
29 citas
Archives of dermatological …
2020
51 citas
The Journal of …
2020
24 citas
Journal of cosmetic …
2019
100 citas
Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.
Other
Avicenna journal of …
2019
23 citas
Evidence-based complementary and …
2015
4 citas
Evidence-based complementary and …
2014
86 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- hairloss:
- 400 mg/day
Límite superior: Not established
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| varies by remedy and study | -- | Positive | -- |
| various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami | -- | Positive | 1658 |
| Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed | -- | Positive | -- |
| finasteride 1 mg/day; dutasteride 0.5 mg/day; various natural product doses | -- | Positive | -- |
| various CAMs: pumpkin seed oil, saw palmetto, melatonin extract, caffeine extract, rosemary oil | -- | Positive | -- |
| not specified | -- | Positive | -- |
Mejor momento para tomar: With meals for better absorption
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Mild gastrointestinal upset
- ⚠ Possible stomach discomfort at high doses
- ⚠ Rare allergic reactions in individuals with cucurbit allergies
Interacciones conocidas
- ● Anticoagulants (theoretical increased bleeding risk)
- ● Lithium (pumpkin seed oil may have diuretic properties)
Ingesta máxima tolerable: Not established
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Aceite de Semilla de Calabaza help with Alopecia Androgenética?
Based on 15 studies with 1,874 participants, there is strong evidence from multiple clinical trials that Aceite de Semilla de Calabaza may support Alopecia Androgenética management. Our evidence grade is A (Strong Evidence).
How much Aceite de Semilla de Calabaza should I take for Alopecia Androgenética?
Studies have used various dosages. A commonly studied range is 400 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aceite de Semilla de Calabaza?
Reported side effects may include Mild gastrointestinal upset, Possible stomach discomfort at high doses, Rare allergic reactions in individuals with cucurbit allergies. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aceite de Semilla de Calabaza and Alopecia Androgenética?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,874 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Alopecia Androgenética
References
- [1] Azhar Ahmed et al.. Skin Appendage Disord. 2025. Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. doi:10.1159/000542876 PubMed
- [2] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [3] Massimo Milani et al.. J Cosmet Dermatol. 2025. Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real-Life, Multicenter, Randomized, Assessor-Blinded Trial … doi:10.1111/jocd.70388 PubMed
- [4] Aditya K Gupta et al.. Skin Appendage Disord. 2025. Do Non-Prescription Products Help in Managing Androgenic Alopecia? doi:10.1159/000542880 PubMed
- [5] Lei Zhou et al.. Front Nutr. 2025. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. doi:10.3389/fnut.2025.1719711 PubMed
- [6] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [7] Promise Ufomadu. Proc (Bayl Univ Med Cent). 2024. Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia. doi:10.1080/08998280.2023.2263829 PubMed
- [8] Aditya K Gupta et al.. Expert Opin Emerg Drugs. 2024. Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia. doi:10.1080/14728214.2024.2346590 PubMed
- [9] Nouf F Bin Rubaian et al.. Clin Cosmet Investig Dermatol. 2024. An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, with Special Emphasis on Rosemary Oil. doi:10.2147/CCID.S470989 PubMed
- [10] Aditya K Gupta et al.. Dermatol Ther. 2022. Natural products for male androgenetic alopecia. doi:10.1111/dth.15323 PubMed
- [11] Ibrahim M Ibrahim et al.. J Cosmet Dermatol. 2021. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. doi:10.1111/jocd.13976 PubMed
- [12] Ana Zgonc Škulj et al.. Arch Dermatol Res. 2020. Herbal preparations for the treatment of hair loss. doi:10.1007/s00403-019-02003-x PubMed
- [13] Nneamaka Ezekwe et al.. J Clin Aesthet Dermatol. 2020. The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic … PubMed
- [14] Maria Yusuf Dhariwala et al.. J Cosmet Dermatol. 2019. An overview of herbal alternatives in androgenetic alopecia. doi:10.1111/jocd.12930 PubMed
- [15] Valiollah Hajhashemi et al.. Avicenna J Phytomed. 2019. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. doi:10.22038/AJP.2019.13463 PubMed
- [16] Hitesh Verma. Evid Based Complement Alternat Med. 2015. Comment on "effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial". doi:10.1155/2015/271474 PubMed
- [17] Young Hye Cho et al.. Evid Based Complement Alternat Med. 2014. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. doi:10.1155/2014/549721 PubMed
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.