硒用于营养缺乏性脱发

基于35项研究（6项荟萃分析、5项RCT），共10,466名参与者。各研究结果不一。

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结论

Research does not support selenium supplementation for hair loss — in fact, excessive selenium intake has been associated with hair loss, so supplementation without a confirmed deficiency is not recommended.

Mixed results across 35 studies — no clear benefit for hair loss
Both selenium deficiency and excess may contribute to hair problems
Case reports have linked selenium supplements to hair loss and nail damage
Only supplement if a healthcare provider has confirmed a deficiency

Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None vs: None Outcome: Cognitive impairment risk 效果: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

研究人群: Elderly participants aged 60+ from NHANES 2011-2014

Systematic Review and Meta-Analysis n=7014

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.

Dose: None vs: Placebo 效果: Standardized mean differences reported for each element and disease combination (specific values not None

prospective controlled study n=30

Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and …

Dose: None vs: Placebo 效果: None None

Review

The role of trace elements for the function and health of the skin.

Dose: None vs: Placebo 效果: None None

Review

Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Review of pharmacogenomics of THC and CBD

Review

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.

Dose: None vs: Placebo 效果: None None

Key Statistics

研究数量

10748

受试者

↔

Mixed

等级

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

Dietary supplementation of male mice with inorganic, organic or nanoparticle selenium preparations: evidence supporting a putative gut-thyroid-male fertility axis. Other

Redox report : … 2025 8 次引用

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. Review

Current medicinal chemistry 2025 5 次引用

The role of trace elements for the function and health of the skin. Review

Journal of trace … 2025 4 次引用

Investigation of ischaemia-modified albumin and antioxidant vitamins and minerals levels in alopecia areata patients and evaluation of their relationship with … Other

Cutaneous and ocular … 2025 1 次引用

Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. Review

Genes 2025 1 次引用

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. Meta-Analysis

Nutrition reviews 2025

A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … Other

Journal of cosmetic … 2024 7 次引用

Micronutrients and Androgenetic Alopecia: A Systematic Review. Systematic Review

Molecular nutrition & … 2024 7 次引用

Selenium in the supplement as the probable cause of hair loss and nail dystrophy. Other

Journal of cosmetic … 2024 4 次引用

Cannabis-based medicines and medical cannabis for adults with cancer pain. Meta-Analysis

The Cochrane database … 2023 47 次引用

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 次引用

Cannabidiol and brain function: current knowledge and future perspectives. Review

Frontiers in pharmacology 2023 29 次引用

Medical and procedural treatment of androgenetic alopecia - Where are we? Review

Journal of the … 2023 20 次引用

Bartter Syndrome: A Systematic Review of Case Reports and Case Series. Systematic Review

Medicina (Kaunas, Lithuania) 2023 17 次引用

Hemp-Derived CBD Used in Food and Food Supplements. Review

Molecules (Basel, Switzerland) 2023 14 次引用

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair … RCT

Skin research and … 2023 11 次引用

CANNabinoid Drug Interaction Review (CANN-DIR™). Review

Medical cannabis and … 2023 9 次引用

Safety and risks of CBD oils purchased online: unveiling uncertain quality and vague health claims. Other

Frontiers in pharmacology 2023 8 次引用

Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic … Other

Italian journal of … 2023 3 次引用

Effects of a Supplement Containing Cannabidiol (CBD) on Sedation and Ataxia Scores and Health. RCT

Journal of equine … 2022 6 次引用

Acceptability of cannabidiol in patients with psychosis. Other

Therapeutic advances in … 2022 4 次引用

A Review of Hemp as Food and Nutritional Supplement. Review

Cannabis and cannabinoid … 2021 171 次引用

The Pharmacological Case for Cannabigerol. Review

The Journal of … 2021 162 次引用

The Impact of Cannabidiol on Psychiatric and Medical Conditions. Review

Journal of clinical … 2020 42 次引用

Alopecia Areata and Toxic Metals. Other

Skin appendage disorders 2020 10 次引用

The Trouble with CBD Oil. Other

Medical cannabis and … 2018 158 次引用

Nutritional Considerations for the Vegetarian and Vegan Dancer. Review

Journal of dance … 2018 15 次引用

The Role of Micronutrients in Alopecia Areata: A Review. Review

American journal of … 2017 104 次引用

Changes of serum trace elements level in patients with alopecia areata: A meta-analysis. Meta-Analysis

The Journal of … 2017 31 次引用

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. Case Report

Acta dermatovenerologica Croatica … 2016 6 次引用

Vitamin B12 and omega-3 fatty acids together regulate lipid metabolism in Wistar rats. Other

Prostaglandins, leukotrienes, and … 2015 40 次引用

[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. Review

Der Internist 2015 3 次引用

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 次引用

[Nutrition and fertility]. Other

Medycyna wieku rozwojowego 2011

A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of … Review

Food and nutrition … 2008 83 次引用

Vitamin B12, folic acid, and the prevention of dementia. Other

The New England … 2006 47 次引用

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 次引用

Element concentrations in serum, erythrocytes, hair and urine of alopecia patients. Other

Acta dermato-venereologica 1986 53 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 55 mcg/day

上限： 400 mcg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	2582
None	--	Mixed	7014
None	--	Neutral	30
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
NaSe 5.6ppm, Met 4.7ppm, DPDS 14.2ppm, NanoSe 2.7ppm	4 weeks	Positive	40
not applicable	--	Mixed	180

最佳服用时间： With meals for better absorption

Safety & Side Effects

已报告的副作用

⚠ Hair loss at excessive doses (selenosis)
⚠ Brittle nails
⚠ Garlic-like breath odor at high doses
⚠ Nausea and diarrhea

已知相互作用

● Statins (selenium may reduce statin effectiveness)
● Chemotherapy drugs (antioxidant effects may theoretically interfere)
● Niacin (may decrease HDL-raising effect when combined)

可耐受最高摄入量： 400 mcg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does 硒 help with 营养缺乏性脱发?

Based on 38 studies with 10,748 participants, there is strong evidence from multiple clinical trials that 硒 may support 营养缺乏性脱发 management. Our evidence grade is A (Strong Evidence).

How much 硒 should I take for 营养缺乏性脱发?

Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of 硒?

Reported side effects may include Hair loss at excessive doses (selenosis), Brittle nails, Garlic-like breath odor at high doses, Nausea and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for 硒 and 营养缺乏性脱发?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 38 peer-reviewed studies with 10,748 total participants. The overall direction of effect is mixed.

Related Evidence

其他成分用于营养缺乏性脱发

生物素（Biotin） B Vitamin A D L-半胱氨酸 D 维生素 B12 F 叶酸（Folate） F

硒用于其他健康状况

甲状腺相关性脱发 A

快速结论

基于35项研究（6项荟萃分析、5项RCT），共10,466名参与者。各研究结果不一。

Evidence Strength92%

High confidence

研究分析

RCT (2)Meta (3)Other (33)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于营养缺乏性脱发

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。

硒 用于 营养缺乏性脱发

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结论

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

常用剂量

研究中使用的剂量

Safety & Side Effects

已报告的副作用

已知相互作用

Frequently Asked Questions

Related Evidence

其他成分用于 营养缺乏性脱发

硒 用于其他健康状况

硒用于营养缺乏性脱发

其他成分用于营养缺乏性脱发

硒用于其他健康状况