酮康唑（Ketoconazole） 用于 头皮银屑病性脱发
A 证据 多项大型临床试验一致显示出显著的益处。基于2项研究（1项荟萃分析），共4,586名参与者。2/2项研究显示积极效果。
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A
结论
Ketoconazole shows strong evidence for supporting scalp health in psoriasis-related hair loss, though the evidence comes from just 2 studies with a large combined participant pool.
- Both studies report positive effects, including a systematic review with 4,586 participants
- Anti-inflammatory properties may help reduce psoriasis-related scalp inflammation
- Ketoconazole shampoo addresses the scalp condition that contributes to hair shedding
- Typically used as a medicated shampoo and may complement other psoriasis management approaches
Key Study Findings
Systematic Review
n=4566
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Dose: various topical ketoconazole formulations
vs: Placebo
效果: Efficacy 63-90% for seborrheic dermatitis; 71-89% for pityriasis versicolor
animal study (randomized controlled)
n=20
3 weeks
Topical application of ketoconazole stimulates hair growth in C3H/HeN mice.
Dose: 2% KCZ in 95% ethanol, once daily
vs: Placebo
效果: None
p<0.01
Key Statistics
2
研究数量
4586
受试者
↑
Positive
A
等级
Referenced Papers
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Systematic Review
The Journal of …
2019
73 次引用
Dermatology and therapy
2016
19 次引用
The British journal …
2011
The Journal of …
2005
24 次引用
Drugs
1998
Lancet (London, England)
1985
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- topical:
- 2% shampoo, 2-3x/week
上限： Topical only for hair loss
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| various topical ketoconazole formulations | -- | Positive | 4566 |
| 2% KCZ in 95% ethanol, once daily | 3 weeks | Positive | 20 |
最佳服用时间： Lather on scalp and leave for 3-5 minutes before rinsing; use 2-3 times per week
Safety & Side Effects
已报告的副作用
- ⚠ Scalp dryness and irritation
- ⚠ Changes in hair texture
- ⚠ Oily or dry scalp (paradoxical)
- ⚠ Contact dermatitis (rare)
已知相互作用
- ● Other topical hair treatments (apply at separate times)
- ● Systemic ketoconazole has many interactions but topical has minimal systemic absorption
可耐受最高摄入量： Topical only for hair loss
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does 酮康唑（Ketoconazole） help with 头皮银屑病性脱发?
Based on 2 studies with 4,586 participants, there is strong evidence from multiple clinical trials that 酮康唑（Ketoconazole） may support 头皮银屑病性脱发 management. Our evidence grade is A (Strong Evidence).
How much 酮康唑（Ketoconazole） should I take for 头皮银屑病性脱发?
Studies have used various dosages. A commonly studied range is 2% shampoo, 2-3x/week. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 酮康唑（Ketoconazole）?
Reported side effects may include Scalp dryness and irritation, Changes in hair texture, Oily or dry scalp (paradoxical), Contact dermatitis (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 酮康唑（Ketoconazole） and 头皮银屑病性脱发?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 2 peer-reviewed studies with 4,586 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 头皮银屑病性脱发
酮康唑（Ketoconazole） 用于其他健康状况
References
- [1] Franchesca D Choi et al.. J Dermatolog Treat. 2019. Topical ketoconazole: a systematic review of current dermatological applications and future developments. doi:10.1080/09546634.2019.1573309 PubMed
- [2] Jeremy Udkoff et al.. Dermatol Ther (Heidelb). 2016. Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn's Disease: Dramatic Improvement after Drug Discontinuation and Treatment with … doi:10.1007/s13555-016-0156-z PubMed
- [3] J-P Ortonne et al.. Br J Dermatol. 2011. Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0·05% combined with ketoconazole shampoo … doi:10.1111/j.1365-2133.2011.10269.x PubMed
- [4] Ju Jiang et al.. J Dermatol. 2005. Topical application of ketoconazole stimulates hair growth in C3H/HeN mice. doi:10.1111/j.1346-8138.2005.tb00756.x PubMed
- [5] A Prakash et al.. Drugs. 1998. Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. doi:10.2165/00003495-199855010-00009 PubMed
- [6] P M Farr et al.. Lancet. 1985. Response of scalp psoriasis to oral ketoconazole. doi:10.1016/s0140-6736(85)90853-0 PubMed
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