Ketoconazole لـ تساقط الشعر بسبب صدفية فروة الرأس
A الأدلة تُظهر تجارب سريرية كبيرة متعددة باستمرار فوائد ملحوظة.بناءً على 2 دراسة (1 meta-analysis) بمشاركة 4,586 مشاركًا إجمالاً. 2/2 دراسة تُظهر تأثيرات إيجابية.
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A
الخلاصة
Ketoconazole shows strong evidence for supporting scalp health in psoriasis-related hair loss, though the evidence comes from just 2 studies with a large combined participant pool.
- Both studies report positive effects, including a systematic review with 4,586 participants
- Anti-inflammatory properties may help reduce psoriasis-related scalp inflammation
- Ketoconazole shampoo addresses the scalp condition that contributes to hair shedding
- Typically used as a medicated shampoo and may complement other psoriasis management approaches
Key Study Findings
Systematic Review
n=4566
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Dose: various topical ketoconazole formulations
مقابل: Placebo
التأثير: Efficacy 63-90% for seborrheic dermatitis; 71-89% for pityriasis versicolor
animal study (randomized controlled)
n=20
3 weeks
Topical application of ketoconazole stimulates hair growth in C3H/HeN mice.
Dose: 2% KCZ in 95% ethanol, once daily
مقابل: Placebo
التأثير: None
p<0.01
Key Statistics
2
الدراسات
4586
المشاركون
↑
Positive
A
التقييم
Referenced Papers
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Systematic Review
The Journal of …
2019
73 اقتباسات
Dermatology and therapy
2016
19 اقتباسات
The British journal …
2011
The Journal of …
2005
24 اقتباسات
Drugs
1998
Lancet (London, England)
1985
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- topical:
- 2% shampoo, 2-3x/week
الحد الأعلى: Topical only for hair loss
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| various topical ketoconazole formulations | -- | Positive | 4566 |
| 2% KCZ in 95% ethanol, once daily | 3 weeks | Positive | 20 |
أفضل وقت للتناول: Lather on scalp and leave for 3-5 minutes before rinsing; use 2-3 times per week
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Scalp dryness and irritation
- ⚠ Changes in hair texture
- ⚠ Oily or dry scalp (paradoxical)
- ⚠ Contact dermatitis (rare)
التفاعلات المعروفة
- ● Other topical hair treatments (apply at separate times)
- ● Systemic ketoconazole has many interactions but topical has minimal systemic absorption
الحد الأقصى المسموح به: Topical only for hair loss
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Ketoconazole help with تساقط الشعر بسبب صدفية فروة الرأس?
Based on 2 studies with 4,586 participants, there is strong evidence from multiple clinical trials that Ketoconazole may support تساقط الشعر بسبب صدفية فروة الرأس management. Our evidence grade is A (Strong Evidence).
How much Ketoconazole should I take for تساقط الشعر بسبب صدفية فروة الرأس?
Studies have used various dosages. A commonly studied range is 2% shampoo, 2-3x/week. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ketoconazole?
Reported side effects may include Scalp dryness and irritation, Changes in hair texture, Oily or dry scalp (paradoxical), Contact dermatitis (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ketoconazole and تساقط الشعر بسبب صدفية فروة الرأس?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 2 peer-reviewed studies with 4,586 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ تساقط الشعر بسبب صدفية فروة الرأس
Ketoconazole لحالات أخرى
References
- [1] Franchesca D Choi et al.. J Dermatolog Treat. 2019. Topical ketoconazole: a systematic review of current dermatological applications and future developments. doi:10.1080/09546634.2019.1573309 PubMed
- [2] Jeremy Udkoff et al.. Dermatol Ther (Heidelb). 2016. Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn's Disease: Dramatic Improvement after Drug Discontinuation and Treatment with … doi:10.1007/s13555-016-0156-z PubMed
- [3] J-P Ortonne et al.. Br J Dermatol. 2011. Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0·05% combined with ketoconazole shampoo … doi:10.1111/j.1365-2133.2011.10269.x PubMed
- [4] Ju Jiang et al.. J Dermatol. 2005. Topical application of ketoconazole stimulates hair growth in C3H/HeN mice. doi:10.1111/j.1346-8138.2005.tb00756.x PubMed
- [5] A Prakash et al.. Drugs. 1998. Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. doi:10.2165/00003495-199855010-00009 PubMed
- [6] P M Farr et al.. Lancet. 1985. Response of scalp psoriasis to oral ketoconazole. doi:10.1016/s0140-6736(85)90853-0 PubMed
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