Microagulhamento para Alopecia Areata
ABaseado em 32 estudos (1 meta-analysis, 9 RCTs) com 1,908 participantes no total. 25/32 estudos mostram efeitos positivos.
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A
Conclusão
Microneedling has strong evidence for supporting hair regrowth in alopecia areata, especially when combined with topical medications, and is backed by multiple randomized controlled trials.
- 25 out of 32 studies show positive effects, with 9 RCTs providing robust evidence
- Works by creating micro-injuries that stimulate healing responses and improve drug absorption
- Most effective when combined with topical agents like corticosteroids or vitamin D3
- Both professional clinical procedures and at-home derma rollers have been studied
Key Study Findings
scoping_review
n=16
A Scoping Review of Exosome Delivery Applications in Hair Loss.
Dose: variable; exosomes predominantly from mesenchymal stem cells (MSCs)
vs: Placebo
Efeito: None
None
retrospective cohort
n=7
Open-label
Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study.
Dose: Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip
vs: Placebo
Efeito: 85.7% achieved complete recovery; 14.3% achieved >50% regrowth; significant SALT score improvement
None
Review
Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven …
Dose: None
vs: Placebo
Efeito: None
None
randomized controlled trial
n=24
18 weeks
Open-label
A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment …
Dose: Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals
vs: Placebo
Efeito: Comparable efficacy between FRM and ILCS; nonsignificant differences in trichoscopic scores, PGA, an
None
review
The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.
Dose: Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera
vs: Placebo
Efeito: Positive outcomes reported for hair density and thickness with microneedling, lasers, LLLT, and PRP
None
animal study
2 weeks
Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing …
Dose: Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment
vs: Placebo
Efeito: Microneedling enhanced hair growth; restored gut microbiome diversity; reduced acetic acid and propa
None
Key Statistics
34
Estudos
1908
Participantes
↑
Positive
A
Nota
Referenced Papers
Cureus
2025
7 citações
Aesthetic plastic surgery
2025
2 citações
Journal of cosmetic …
2025
1 citações
Italian journal of …
2025
Dermatology reports
2025
Dermatologic surgery : …
2025
Frontiers in microbiology
2025
Lasers in medical …
2024
10 citações
Skin appendage disorders
2024
5 citações
PloS one
2024
4 citações
Skin research and …
2024
3 citações
The Journal of …
2024
2 citações
Journal of cosmetic …
2023
8 citações
Clinical, cosmetic and …
2023
3 citações
Dermatology and therapy
2022
43 citações
Archives of dermatological …
2022
16 citações
Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata.
RCT
The Journal of …
2022
9 citações
Dermatologic therapy
2022
9 citações
Microneedling combined with compound betamethasone in treatment of severe alopecia areata: A case report.
Case Report
Frontiers in immunology
2022
8 citações
Dermatologic therapy
2022
8 citações
International journal of …
2022
1 citações
Aesthetic plastic surgery
2021
8 citações
Dermatologic therapy
2021
7 citações
Clinical and experimental …
2020
27 citações
Acta dermatovenerologica Alpina, …
2020
24 citações
Journal of the …
2020
10 citações
Proceedings (Baylor University. …
2020
8 citações
Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases.
Case Report
Skin appendage disorders
2020
6 citações
Cureus
2019
18 citações
Journal of cosmetic …
2019
14 citações
Journal of the …
2018
114 citações
The journal of …
2018
25 citações
The Journal of …
2017
1 citações
Journal of cutaneous …
2014
80 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- hairloss:
- 1.5 mm depth, weekly sessions
Limite superior: Not applicable
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| variable; exosomes predominantly from mesenchymal stem cells (MSCs) | -- | Positive | 16 |
| Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip | -- | Positive | 7 |
| None | -- | Mixed | -- |
| Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals | 18 weeks | Neutral | 24 |
| Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera | -- | Positive | -- |
| Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment | 2 weeks | Positive | -- |
| Microinfusion of medications into the skin (MMP) using tattoo devices; various drugs (minoxidil, ste | -- | Positive | -- |
| Melatonin 3 mg/kg; PBM diode laser 660nm, 100mW, 3 J/point, 2 sessions/week | 12 weeks | Mixed | 60 |
Melhor horário: Weekly sessions; avoid minoxidil for 24 hours post-treatment
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Scalp redness and inflammation (24-72 hours)
- ⚠ Mild bleeding at treatment site
- ⚠ Scalp tenderness and soreness
- ⚠ Rare: infection if proper sterilization not maintained
Interações Conhecidas
- ● Topical minoxidil (enhanced absorption; wait 24 hours after microneedling to apply)
- ● Blood thinners (may increase bleeding during procedure)
- ● Topical retinoids (discontinue 3-5 days before treatment)
Ingestão máxima tolerável: Not applicable
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Microagulhamento help with Alopecia Areata?
Based on 34 studies with 1,908 participants, there is strong evidence from multiple clinical trials that Microagulhamento may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).
How much Microagulhamento should I take for Alopecia Areata?
Studies have used various dosages. A commonly studied range is 1.5 mm depth, weekly sessions. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Microagulhamento?
Reported side effects may include Scalp redness and inflammation (24-72 hours), Mild bleeding at treatment site, Scalp tenderness and soreness, Rare: infection if proper sterilization not maintained. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Microagulhamento and Alopecia Areata?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 1,908 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Alopecia Areata
Microagulhamento para outras condições
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.