Microneedling untuk Alopecia Areata
A Bukti Beberapa uji klinis besar secara konsisten menunjukkan manfaat yang signifikan.Berdasarkan 32 studi (1 meta-analysis, 9 RCTs) dengan 1,908 peserta secara total. 25/32 studi menunjukkan efek positif.
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A
Kesimpulan
Microneedling has strong evidence for supporting hair regrowth in alopecia areata, especially when combined with topical medications, and is backed by multiple randomized controlled trials.
- 25 out of 32 studies show positive effects, with 9 RCTs providing robust evidence
- Works by creating micro-injuries that stimulate healing responses and improve drug absorption
- Most effective when combined with topical agents like corticosteroids or vitamin D3
- Both professional clinical procedures and at-home derma rollers have been studied
Key Study Findings
scoping_review
n=16
A Scoping Review of Exosome Delivery Applications in Hair Loss.
Dose: variable; exosomes predominantly from mesenchymal stem cells (MSCs)
vs: Placebo
Efek: None
None
retrospective cohort
n=7
Open-label
Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study.
Dose: Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip
vs: Placebo
Efek: 85.7% achieved complete recovery; 14.3% achieved >50% regrowth; significant SALT score improvement
None
Review
Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven …
Dose: None
vs: Placebo
Efek: None
None
randomized controlled trial
n=24
18 weeks
Open-label
A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment …
Dose: Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals
vs: Placebo
Efek: Comparable efficacy between FRM and ILCS; nonsignificant differences in trichoscopic scores, PGA, an
None
review
The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.
Dose: Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera
vs: Placebo
Efek: Positive outcomes reported for hair density and thickness with microneedling, lasers, LLLT, and PRP
None
animal study
2 weeks
Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing …
Dose: Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment
vs: Placebo
Efek: Microneedling enhanced hair growth; restored gut microbiome diversity; reduced acetic acid and propa
None
Key Statistics
34
Studi
1908
Peserta
↑
Positive
A
Peringkat
Referenced Papers
Cureus
2025
7 sitasi
Aesthetic plastic surgery
2025
2 sitasi
Journal of cosmetic …
2025
1 sitasi
Italian journal of …
2025
Dermatology reports
2025
Dermatologic surgery : …
2025
Frontiers in microbiology
2025
Lasers in medical …
2024
10 sitasi
Skin appendage disorders
2024
5 sitasi
PloS one
2024
4 sitasi
Skin research and …
2024
3 sitasi
The Journal of …
2024
2 sitasi
Journal of cosmetic …
2023
8 sitasi
Clinical, cosmetic and …
2023
3 sitasi
Dermatology and therapy
2022
43 sitasi
Archives of dermatological …
2022
16 sitasi
Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata.
RCT
The Journal of …
2022
9 sitasi
Dermatologic therapy
2022
9 sitasi
Microneedling combined with compound betamethasone in treatment of severe alopecia areata: A case report.
Case Report
Frontiers in immunology
2022
8 sitasi
Dermatologic therapy
2022
8 sitasi
International journal of …
2022
1 sitasi
Aesthetic plastic surgery
2021
8 sitasi
Dermatologic therapy
2021
7 sitasi
Clinical and experimental …
2020
27 sitasi
Acta dermatovenerologica Alpina, …
2020
24 sitasi
Journal of the …
2020
10 sitasi
Proceedings (Baylor University. …
2020
8 sitasi
Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases.
Case Report
Skin appendage disorders
2020
6 sitasi
Cureus
2019
18 sitasi
Journal of cosmetic …
2019
14 sitasi
Journal of the …
2018
114 sitasi
The journal of …
2018
25 sitasi
The Journal of …
2017
1 sitasi
Journal of cutaneous …
2014
80 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- hairloss:
- 1.5 mm depth, weekly sessions
Batas atas: Not applicable
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| variable; exosomes predominantly from mesenchymal stem cells (MSCs) | -- | Positive | 16 |
| Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip | -- | Positive | 7 |
| None | -- | Mixed | -- |
| Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals | 18 weeks | Neutral | 24 |
| Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera | -- | Positive | -- |
| Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment | 2 weeks | Positive | -- |
| Microinfusion of medications into the skin (MMP) using tattoo devices; various drugs (minoxidil, ste | -- | Positive | -- |
| Melatonin 3 mg/kg; PBM diode laser 660nm, 100mW, 3 J/point, 2 sessions/week | 12 weeks | Mixed | 60 |
Waktu terbaik diminum: Weekly sessions; avoid minoxidil for 24 hours post-treatment
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Scalp redness and inflammation (24-72 hours)
- ⚠ Mild bleeding at treatment site
- ⚠ Scalp tenderness and soreness
- ⚠ Rare: infection if proper sterilization not maintained
Interaksi yang Diketahui
- ● Topical minoxidil (enhanced absorption; wait 24 hours after microneedling to apply)
- ● Blood thinners (may increase bleeding during procedure)
- ● Topical retinoids (discontinue 3-5 days before treatment)
Asupan atas yang dapat ditoleransi: Not applicable
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Microneedling help with Alopecia Areata?
Based on 34 studies with 1,908 participants, there is strong evidence from multiple clinical trials that Microneedling may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).
How much Microneedling should I take for Alopecia Areata?
Studies have used various dosages. A commonly studied range is 1.5 mm depth, weekly sessions. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Microneedling?
Reported side effects may include Scalp redness and inflammation (24-72 hours), Mild bleeding at treatment site, Scalp tenderness and soreness, Rare: infection if proper sterilization not maintained. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Microneedling and Alopecia Areata?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 1,908 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Alopecia Areata
Microneedling untuk kondisi lain
References
- [1] Sarah Schaffer et al.. Cureus. 2025. A Scoping Review of Exosome Delivery Applications in Hair Loss. doi:10.7759/cureus.81152 PubMed
- [2] Xuexue Pan et al.. Aesthetic Plast Surg. 2025. Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation. doi:10.1007/s00266-025-05077-3 PubMed
- [3] Lingling Jia et al.. J Cosmet Dermatol. 2025. Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study. doi:10.1111/jocd.16591 PubMed
- [4] Woo C Tay et al.. Ital J Dermatol Venerol. 2025. The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia. doi:10.23736/S2784-8671.25.08232-5 PubMed
- [5] Khalid Nabil Nagshabandi et al.. Dermatol Reports. 2025. Microinfusion of medications into the skin as a drug delivery technique: a narrative review. doi:10.4081/dr.2025.10306 PubMed
- [6] Eman Raafat Said et al.. Dermatol Surg. 2025. A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment of Alopecia Areata. doi:10.1097/DSS.0000000000004619 PubMed
- [7] Yue Zhang et al.. Front Microbiol. 2025. Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing and metabolomics. doi:10.3389/fmicb.2025.1649496 PubMed
- [8] Eliza Balazic et al.. Lasers Med Sci. 2024. The role of laser and energy-assisted drug delivery in the treatment of alopecia. doi:10.1007/s10103-024-04015-0 PubMed
- [9] Malak M Almutlq et al.. Skin Appendage Disord. 2024. Growth Factors and Microneedling in Alopecia Areata: A Narrative Review. doi:10.1159/000534636 PubMed
- [10] Flaviana Amado Martins et al.. PLoS One. 2024. Comparison between melatonin versus melatonin and photobiomodulation versus photobiomodulation in the treatment of Alopecia X in German Spitz dogs: Clinical, … doi:10.1371/journal.pone.0304605 PubMed
- [11] Fanglin Wei et al.. Skin Res Technol. 2024. Effect of minoxidil combined with triamcinolone acetonide on alopecia areata by microneedle injection. doi:10.1111/srt.13713 PubMed
- [12] Yutong Xie et al.. J Dermatolog Treat. 2024. Cosmetic filler-induced hair loss: case series and literature review. doi:10.1080/09546634.2024.2443111 PubMed
- [13] Mona S Ali et al.. J Cosmet Dermatol. 2023. Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized … doi:10.1111/jocd.15569 PubMed
- [14] Jiong Zhou et al.. Clin Cosmet Investig Dermatol. 2023. Efficacy, safety, and Pharmacoeconomics of Three Common Strategies for Pediatric Alopecia Areata Patients: A Retrospective Cohort Study. doi:10.2147/CCID.S425534 PubMed
- [15] Robert S English et al.. Dermatol Ther (Heidelb). 2022. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. doi:10.1007/s13555-021-00653-2 PubMed
- [16] Seon Bok Lee et al.. Arch Dermatol Res. 2022. Clinical efficacy of adipocyte-derived stem cells conditioned media combined with micro-injury in refractory patch of alopecia areata. doi:10.1007/s00403-021-02252-9 PubMed
- [17] Mahmoud Abd El-Rahim Abdallah et al.. J Dermatolog Treat. 2022. Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata. doi:10.1080/09546634.2020.1793893 PubMed
- [18] Faten Abd ElWadoud Abd ElKawy et al.. Dermatol Ther. 2022. Fractional CO2 laser versus microneedling as a transepidermal drug delivery system for the treatment of alopecia areata: A clinical dermoscopic … doi:10.1111/dth.15553 PubMed
- [19] Danning Pei et al.. Front Immunol. 2022. Microneedling combined with compound betamethasone in treatment of severe alopecia areata: A case report. doi:10.3389/fimmu.2022.939077 PubMed
- [20] Mai Mohamed Omar et al.. Dermatol Ther. 2022. Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant … doi:10.1111/dth.15913 PubMed
- [21] Astha Arora et al.. Int J Trichology. 2022. Comparative Efficacy of Injection Triamcinolone Acetonide given Intralesionally and through Microneedling in Alopecia areata. doi:10.4103/ijt.ijt_140_20 PubMed
- [22] Benjamin Talei et al.. Aesthetic Plast Surg. 2021. Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series. doi:10.1007/s00266-021-02406-0 PubMed
- [23] Soha Aboeldahab et al.. Dermatol Ther. 2021. Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single-blinded randomized … doi:10.1111/dth.15044 PubMed
- [24] C M Giorgio et al.. Clin Exp Dermatol. 2020. Combination of photodynamic therapy with 5-aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our … doi:10.1111/ced.14084 PubMed
- [25] Sally Esam Marouf Ragab et al.. Acta Dermatovenerol Alp Pannonica Adriat. 2020. Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or … PubMed
- [26] Olivera Stojadinovic et al.. J Am Acad Dermatol. 2020. Adverse effects of platelet-rich plasma and microneedling. doi:10.1016/j.jaad.2019.07.109 PubMed
- [27] Usman Asad et al.. Proc (Bayl Univ Med Cent). 2020. Ophiasis alopecia areata treated with microneedling. doi:10.1080/08998280.2020.1753456 PubMed
- [28] Marina Barletta et al.. Skin Appendage Disord. 2020. Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases. doi:10.1159/000506314 PubMed
- [29] Robert J Dabek et al.. Cureus. 2019. Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review. doi:10.7759/cureus.4943 PubMed
- [30] Angela Wipf et al.. J Cosmet Laser Ther. 2019. The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards … doi:10.1080/14764172.2018.1525743 PubMed
- [31] R M Fertig et al.. J Eur Acad Dermatol Venereol. 2018. Microneedling for the treatment of hair loss? doi:10.1111/jdv.14722 PubMed
- [32] Lauren C Strazzulla et al.. J Investig Dermatol Symp Proc. 2018. An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. doi:10.1016/j.jisp.2017.10.002 PubMed
- [33] Lauren C Strazzulla et al.. J Invest Dermatol. 2017. WITHDRAWN: An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. doi:10.1016/j.jid.2017.07.827 PubMed
- [34] Bs Chandrashekar et al.. J Cutan Aesthet Surg. 2014. Alopecia areata-successful outcome with microneedling and triamcinolone acetonide. doi:10.4103/0974-2077.129989 PubMed
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