Keratin para Afinamento Capilar Relacionado à Idade

A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.

Baseado em 32 estudos (5 RCTs) com 495 participantes no total. 21/32 estudos mostram efeitos positivos.

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Conclusão

Keratin supplements show good evidence for supporting hair growth in age-related thinning, with multiple RCTs reporting positive results, though the research includes a mix of direct and indirect evidence.

21 out of 32 studies show positive effects, including 5 randomized controlled trials
Annurca apple-derived keratin formulations have shown particularly promising results in RCTs
Keratin-related signaling pathways are well-established as important for hair follicle health
Some evidence is from laboratory studies, so real-world effectiveness may vary

Key Study Findings

Other

TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis.

Dose: None vs: untreated controls Outcome: hair follicle transition from telogen to anagen phase Efeito: None None

População: female and male rats, naturally aged and DHT-induced alopecia model mice

in vitro/ex vivo study

A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond …

Dose: USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu vs: Placebo Efeito: USPlus DERM IC50=0.39 μg/mL (vs 29.1 μg/mL standard extract); 0.4 μg/mL significantly reduced melani None

Animal/Laboratory Study

IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice.

Dose: Corticosteroid injections (dose not specified) in transgenic mice vs: Placebo Efeito: None None

Observational Study n=144 Open-label

Alternative and Complimentary Medication Use in Singers: A Pilot Survey.

Dose: None vs: None Outcome: Self-reported use patterns and perceived vocal effects Efeito: None None

População: Singers with varying singing styles, mean age 51.8y

Review

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.

Dose: None vs: None Outcome: Pregnancy outcomes and offspring neurodevelopment Efeito: None None

População: Pregnant women (review)

Review

Cannabidiol (CBD) as an emerging nutraceutical ingredient from industrial hemp: regulation, production, extraction, nutraceutical properties, …

Dose: None vs: None Outcome: CBD food applications and functional properties Efeito: None None

População: General population (review of CBD in food industry)

Key Statistics

Estudos

6199

Participantes

↔

Mixed

Nota

Referenced Papers

TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis. Other

Biochemical pharmacology 2026

Cannabidiol (CBD) as an emerging nutraceutical ingredient from industrial hemp: regulation, production, extraction, nutraceutical properties, and functionality. Review

Critical reviews in … 2025 5 citações

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. Review

The Proceedings of … 2025 5 citações

Alternative and Complimentary Medication Use in Singers: A Pilot Survey. Other

Journal of voice … 2025 2 citações

IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice. Other

Experimental dermatology 2025 2 citações

A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … Other

International journal of … 2025 1 citações

Tolerability of long-term cannabidiol supplementation to healthy adult dogs. RCT

Journal of veterinary … 2024 19 citações

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 citações

Safety study of cannabidiol products in healthy dogs. Other

Frontiers in veterinary … 2024 11 citações

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. Other

Poultry science 2024 9 citações

Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle? Review

International journal of … 2024 5 citações

Does a broad-spectrum cannabidiol supplement improve performance in a 10-min cycle ergometer performance-test? RCT

European journal of … 2024 4 citações

Prevalence of Dietary Modification and Supplement Use in Patients with Metastatic Renal Cell Carcinoma Receiving Systemic Therapy. Other

Nutrients 2024 2 citações

Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system. Other

Journal of animal … 2024

The Role of One-Carbon Metabolism in Healthy Brain Aging. Review

Nutrients 2023 9 citações

Reply to "Vitamin D status in scarring and nonscarring alopecia". Other

Journal of the … 2022 6 citações

Acceptability of cannabidiol in patients with psychosis. Other

Therapeutic advances in … 2022 4 citações

Role of vitamin D in hair loss: A short review. Review

Journal of cosmetic … 2021 44 citações

Feeding Cannabidiol (CBD)-Containing Treats Did Not Affect Canine Daily Voluntary Activity. Other

Frontiers in veterinary … 2021 26 citações

Nutrient intakes from supplement and factors associated with supplement use among breast cancer survivors: A cross-sectional study. Other

European journal of … 2021 5 citações

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? Review

Experimental dermatology 2020 10 citações

Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss. Other

Indian journal of … 2020 5 citações

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Other

Molecules (Basel, Switzerland) 2019 137 citações

Decarbonylation: A metabolic pathway of cannabidiol in humans. Other

Drug testing and … 2019 31 citações

Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study. Other

Breast cancer research … 2019 25 citações

Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. Other

Clinical, cosmetic and … 2019 7 citações

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Other

Clinical, cosmetic and … 2018 16 citações

Vitamin D Level in Alopecia Areata. Other

Indian journal of … 2017 46 citações

Correspondence of folate dietary intake and biomarker data. Other

The American journal … 2017 34 citações

Zinc and skin biology. Review

Archives of biochemistry … 2016 124 citações

Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. Other

Journal of cosmetic … 2016 43 citações

[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. Review

Ginekologia polska 2015 7 citações

Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. Meta-Analysis

Clinical nutrition (Edinburgh, … 2014 12 citações

Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. Systematic Review

International journal of … 2012 19 citações

Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic Acid and saw palmetto extract. Other

Evidence-based complementary and … 2011 27 citações

[Vitamin B6 (Pyridoxine)--excessive dosage in food supplements and OTC medications]. Review

Harefuah 2004

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

hairloss:: 500 mg/day

Limite superior: Not established

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Positive	--
USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu	--	Positive	--
Corticosteroid injections (dose not specified) in transgenic mice	--	Positive	--
None	--	Neutral	144
None	--	Positive	--
None	--	Positive	--
None	--	Neutral	--
5 or 10 mg/kg BW/day	36 weeks	Neutral	18

Melhor horário: With meals for better absorption

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Generally well tolerated
⚠ Mild gastrointestinal discomfort in some individuals
⚠ Rare allergic reactions

Interações Conhecidas

● No significant drug interactions established
● May interact with protein absorption in individuals with digestive disorders

Ingestão máxima tolerável: Not established

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Keratin help with Afinamento Capilar Relacionado à Idade?

Based on 36 studies with 6,199 participants, there is strong evidence from multiple clinical trials that Keratin may support Afinamento Capilar Relacionado à Idade management. Our evidence grade is A (Strong Evidence).

How much Keratin should I take for Afinamento Capilar Relacionado à Idade?

Studies have used various dosages. A commonly studied range is 500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Keratin?

Reported side effects may include Generally well tolerated, Mild gastrointestinal discomfort in some individuals, Rare allergic reactions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Keratin and Afinamento Capilar Relacionado à Idade?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 36 peer-reviewed studies with 6,199 total participants. The overall direction of effect is mixed.

Outros ingredientes para Afinamento Capilar Relacionado à Idade

Viviscal A Colágeno A MSM B Vitamin E D Extrato de cavalinha D Copper Peptides (GHK-Cu) D

Keratin para outras condições

Telogen Effluvium B

Veredito Rápido

Baseado em 32 estudos (5 RCTs) com 495 participantes no total. 21/32 estudos mostram efeitos positivos.

Evidence Strength92%

High confidence

Detalhamento dos Estudos

RCT (2)Meta (2)Other (32)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Afinamento Capilar Relacionado à Idade

Saiba Mais

References

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[3] Kristina Pentieva et al.. Proc Nutr Soc. 2025. B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. doi:10.1017/S0029665124004865 PubMed
[4] Granit Mavraj et al.. J Voice. 2025. Alternative and Complimentary Medication Use in Singers: A Pilot Survey. doi:10.1016/j.jvoice.2022.08.021 PubMed
[5] Yukiyasu Arakawa et al.. Exp Dermatol. 2025. IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice. doi:10.1111/exd.70074 PubMed
[6] David Broadley et al.. Int J Cosmet Sci. 2025. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … doi:10.1111/ics.70035 PubMed
[7] Isabella Corsato Alvarenga et al.. J Vet Intern Med. 2024. Tolerability of long-term cannabidiol supplementation to healthy adult dogs. doi:10.1111/jvim.16949 PubMed
[8] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
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[10] Guangtian Cao et al.. Poult Sci. 2024. Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. doi:10.1016/j.psj.2024.103966 PubMed
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[14] Nadia Musco et al.. J Anim Sci. 2024. Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system. doi:10.1093/jas/skae376 PubMed
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[16] Shawn Afvari et al.. J Am Acad Dermatol. 2022. Reply to "Vitamin D status in scarring and nonscarring alopecia". doi:10.1016/j.jaad.2022.04.055 PubMed
[17] Edward Chesney et al.. Ther Adv Psychopharmacol. 2022. Acceptability of cannabidiol in patients with psychosis. doi:10.1177/20451253221128445 PubMed
[18] Kriteeka Saini et al.. J Cosmet Dermatol. 2021. Role of vitamin D in hair loss: A short review. doi:10.1111/jocd.14421 PubMed
[19] Elizabeth M Morris et al.. Front Vet Sci. 2021. Feeding Cannabidiol (CBD)-Containing Treats Did Not Affect Canine Daily Voluntary Activity. doi:10.3389/fvets.2021.645667 PubMed
[20] Jiyoung Youn et al.. Eur J Cancer Care (Engl). 2021. Nutrient intakes from supplement and factors associated with supplement use among breast cancer survivors: A cross-sectional study. doi:10.1111/ecc.13447 PubMed
[21] Ralf Paus et al.. Exp Dermatol. 2020. Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? doi:10.1111/exd.14156 PubMed
[22] Iman Seleit et al.. Indian J Dermatol. 2020. Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss. doi:10.4103/ijd.IJD_482_18 PubMed
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[24] Michael Kraemer et al.. Drug Test Anal. 2019. Decarbonylation: A metabolic pathway of cannabidiol in humans. doi:10.1002/dta.2572 PubMed
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[26] Iman Seleit et al.. Clin Cosmet Investig Dermatol. 2019. Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. doi:10.2147/CCID.S227232 PubMed
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[28] Yasmeen Jabeen Bhat et al.. Indian J Dermatol. 2017. Vitamin D Level in Alopecia Areata. doi:10.4103/ijd.IJD_677_16 PubMed
[29] Regan L Bailey et al.. Am J Clin Nutr. 2017. Correspondence of folate dietary intake and biomarker data. doi:10.3945/ajcn.116.148775 PubMed
[30] Youichi Ogawa et al.. Arch Biochem Biophys. 2016. Zinc and skin biology. doi:10.1016/j.abb.2016.06.003 PubMed
[31] Marwa M T Fawzi et al.. J Cosmet Dermatol. 2016. Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. doi:10.1111/jocd.12224 PubMed
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[33] Xianhui Qin et al.. Clin Nutr. 2014. Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. doi:10.1016/j.clnu.2014.01.006 PubMed
[34] Szimonetta Lohner et al.. Int J Food Sci Nutr. 2012. Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. doi:10.3109/09637486.2012.683779 PubMed
[35] Sridar Chittur et al.. Evid Based Complement Alternat Med. 2011. Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic Acid and saw palmetto extract. doi:10.1093/ecam/nep102 PubMed
[36] Nir Barak et al.. Harefuah. 2004. [Vitamin B6 (Pyridoxine)--excessive dosage in food supplements and OTC medications]. PubMed

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.