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Dutasteride para Alopecia Androgenética

A

Baseado em 43 estudos (7 meta-analyses, 1 RCT) com 12,060 participantes no total. 34/43 estudos mostram efeitos positivos.

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A

Conclusão

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

  • 34 out of 43 studies show positive effects across 12,060 participants
  • Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
  • Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
  • Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None Efeito: None None

População: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind
Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …
Dose: 0.2 mg dutasteride daily vs: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline Efeito: 21.53 vs 5.96 hair count increase 0.0072

População: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.
Dose: 3 sessions of dutasteride microinfusion (monthly) vs: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment Efeito: None None

População: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label
Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …
Dose: 4 monthly sessions of SPi + iontophoresis vs: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … Efeito: None <0.001 (density, diam, pull)

População: 10 males + 10 postmenopausal females with resistant AGA

Review
Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.
Dose: Dutasteride (oral, various doses) vs: Placebo Efeito: None None
Review
Male and female pattern hair loss.
Dose: None vs: Placebo Efeito: None None

Key Statistics

99

Estudos

19921

Participantes

Positive

A

Nota

Referenced Papers

Journal of cosmetic … 2025 3 citações
Australian prescriber 2025 2 citações
Journal of cutaneous … 2025 2 citações
Journal of clinical … 2025 1 citações
Annals of dermatology 2025
Dermatology (Basel, Switzerland) 2024 14 citações
Journal of cosmetic … 2024 11 citações
Facial plastic surgery … 2024 8 citações
American journal of … 2023 41 citações
Dermatology and therapy 2023 23 citações
Fertility and sterility 2020 94 citações
Neurobiology of stress 2020 72 citações
General and comparative … 2020 37 citações
Facial plastic surgery … 2020 15 citações
Alternative therapies in … 2020 11 citações
Archivos espanoles de … 2020 1 citações
The aging male … 2019 19 citações
Assay and drug … 2019 19 citações
Expert opinion on … 2018 38 citações
Current clinical pharmacology 2017 62 citações
International journal of … 2017 45 citações
Actas dermo-sifiliograficas 2017 17 citações
The Cochrane database … 2016 18 citações
Indian journal of … 2016 8 citações
Current problems in … 2015 8 citações
Expert opinion on … 2014 57 citações
Current opinion in … 2014 43 citações
Dermatologic clinics 2013 78 citações
Journal of cosmetic … 2013 62 citações
Facial plastic surgery … 2013 16 citações
International journal of … 2013
Expert opinion on … 2010 264 citações
Current opinion in … 2009 54 citações
Seminars in cutaneous … 2009 4 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

hairloss:
0.5 mg/day (off-label)

Limite superior: 0.5 mg/day

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Neutral --
0.2 mg dutasteride daily 24 weeks Positive 139
3 sessions of dutasteride microinfusion (monthly) 12 weeks Positive 8
4 monthly sessions of SPi + iontophoresis 8 weeks Positive 20
Dutasteride (oral, various doses) -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --

Melhor horário: Once daily at the same time, with or without food; prescription required

Safety & Side Effects

Efeitos Colaterais Relatados

  • Decreased libido (more common than finasteride)
  • Erectile dysfunction
  • Ejaculation disorders
  • Gynecomastia (breast tissue growth)
  • Very long half-life (~5 weeks) means slow side effect resolution

Interações Conhecidas

  • CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
  • May affect PSA levels (reduces by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

Ingestão máxima tolerável: 0.5 mg/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Dutasteride help with Alopecia Androgenética?
Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that Dutasteride may support Alopecia Androgenética management. Our evidence grade is A (Strong Evidence).
How much Dutasteride should I take for Alopecia Androgenética?
Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Dutasteride?
Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Dutasteride and Alopecia Androgenética?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.