ケトコナゾール ： 男性型・女性型脱毛症（AGA）
A合計5,154名の参加者を対象とした17件の研究（メタアナリシス3件、RCT 2件を含む）に基づく。17件中16件の研究で肯定的な効果が示されている。
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A
結論
Ketoconazole shampoo has strong evidence supporting its use for androgenetic alopecia, working through both antifungal and anti-androgenic mechanisms, and is recommended as a complement to other hair loss approaches.
- 16 out of 17 studies show positive effects across 5,154 participants
- Works through dual mechanisms: antifungal scalp benefits and local anti-androgenic activity
- Included in clinical guidelines as a complementary approach for pattern hair loss
- Typically used as a 1-2% shampoo applied 2-3 times per week
Key Study Findings
Review
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.
Dose: None
vs: None
Outcome: scalp microbiome alterations in androgenetic alopecia
効果: None
None
対象集団: patients with androgenetic alopecia
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
効果: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
Review
A Canadian Consensus on Androgenetic Alopecia: Approach and Management.
Dose: None
vs: Placebo
効果: None
None
systematic review
Management of androgenic alopecia: a systematic review of the literature.
Dose: various across 141 included studies
vs: Placebo
効果: multiple treatments shown to successfully promote hair growth; superiority of multifaceted individua
None
Systematic Review
n=318
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
Dose: None
vs: Placebo
効果: Increased hair shaft diameter; significant increase in pilary index; clinical improvement by photogr
None
narrative review
Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris.
Dose: varies
vs: Placebo
効果: None
None
Key Statistics
19
研究数
5154
参加者数
↑
Positive
A
グレード
Referenced Papers
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.
Review
International journal of …
2026
Journal of cutaneous …
2025
2 件の引用
International journal of …
2025
Journal of cosmetic …
2024
11 件の引用
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
Systematic Review
Dermatologic therapy
2020
34 件の引用
American journal of …
2020
24 件の引用
Alternative therapies in …
2020
11 件の引用
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
Systematic Review
The Journal of …
2019
73 件の引用
Pharmaceutics
2019
7 件の引用
The Journal of …
2018
69 件の引用
Female pattern hair loss.
Review
Current problems in …
2015
8 件の引用
Androgenetic alopecia.
Review
Giornale italiano di …
2014
8 件の引用
ISRN pharmacology
2014
International journal of …
2013
Skin therapy letter
2012
100 件の引用
ISRN dermatology
2011
Clinics in dermatology
2010
Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity.
Other
Journal of dermatological …
2007
39 件の引用
Georgian medical news
2007
The Journal of …
2005
24 件の引用
Medical hypotheses
2004
21 件の引用
The Journal of …
2002
96 件の引用
International journal of …
2002
53 件の引用
Dermatology (Basel, Switzerland)
1998
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- topical:
- 2% shampoo, 2-3x/week
上限量： Topical only for hair loss
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Negative | -- |
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| various across 141 included studies | -- | Positive | -- |
| None | -- | Positive | 318 |
| varies | -- | Positive | -- |
| dutasteride and ketoconazole at pharmacokinetic study doses in rats (not specified in abstract) | -- | Mixed | -- |
| various topical ketoconazole formulations | -- | Positive | 4566 |
推奨摂取タイミング： Lather on scalp and leave for 3-5 minutes before rinsing; use 2-3 times per week
Safety & Side Effects
報告されている副作用
- ⚠ Scalp dryness and irritation
- ⚠ Changes in hair texture
- ⚠ Oily or dry scalp (paradoxical)
- ⚠ Contact dermatitis (rare)
既知の相互作用
- ● Other topical hair treatments (apply at separate times)
- ● Systemic ketoconazole has many interactions but topical has minimal systemic absorption
耐容上限摂取量： Topical only for hair loss
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does ケトコナゾール help with 男性型・女性型脱毛症（AGA）?
Based on 19 studies with 5,154 participants, there is strong evidence from multiple clinical trials that ケトコナゾール may support 男性型・女性型脱毛症（AGA） management. Our evidence grade is A (Strong Evidence).
How much ケトコナゾール should I take for 男性型・女性型脱毛症（AGA）?
Studies have used various dosages. A commonly studied range is 2% shampoo, 2-3x/week. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of ケトコナゾール?
Reported side effects may include Scalp dryness and irritation, Changes in hair texture, Oily or dry scalp (paradoxical), Contact dermatitis (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for ケトコナゾール and 男性型・女性型脱毛症（AGA）?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 19 peer-reviewed studies with 5,154 total participants. The overall direction of effect is positive.
Related Evidence
ケトコナゾール 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。