Saw Palmetto per Alopecia androgenetica
A Evidenze Più grandi trial clinici mostrano in modo costante benefici significativi.Basato su 21 studi (2 meta-analyses, 4 RCTs) con 2,123 partecipanti totali. 20/21 studi mostrano effetti positivi.
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A
In sintesi
Saw palmetto is well-supported by clinical research as a natural supplement that may help slow hair loss and support regrowth in androgenetic alopecia by naturally inhibiting DHT production.
- 95% of studies (20/21) show positive effects, including 4 RCTs and 2 meta-analyses
- Works as a natural 5-alpha reductase inhibitor, reducing DHT levels
- Both oral supplementation and topical application have demonstrated benefits
- Generally well-tolerated, though less potent than prescription finasteride
Key Study Findings
Review
The Over-The-Counter Finasteride Alternative: A Critical Review of Saw Palmetto's Efficacy, Safety, and Regulatory Concerns.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
RCT
n=80
24 weeks
Double-blind
Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium …
Dose: 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien
vs: Placebo
Effetto: MD=+12.3 hairs/cm2 at 6 months
p<0.05
narrative review
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
Dose: None
vs: Placebo
Effetto: None
None
narrative review
Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.
Dose: varies by remedy and study
vs: Placebo
Effetto: None
None
systematic review
n=1658
Double-blind
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Dose: various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami
vs: Placebo
Effetto: None
None
review
Single-blind
Do Non-Prescription Products Help in Managing Androgenic Alopecia?
Dose: Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed
vs: Placebo
Effetto: Considerable improvements in one or more parameters across 13 included studies
None
Key Statistics
22
Studi
2123
Partecipanti
↑
Positive
A
Grado
Referenced Papers
International journal of …
2026
1 citazioni
Skin appendage disorders
2025
7 citazioni
Skin appendage disorders
2025
3 citazioni
Frontiers in bioinformatics
2025
2 citazioni
International journal of …
2025
1 citazioni
Journal of cosmetic …
2025
1 citazioni
Skin appendage disorders
2025
1 citazioni
Journal of drugs …
2025
Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
Systematic Review
Frontiers in nutrition
2025
Proceedings (Baylor University. …
2024
14 citazioni
Expert opinion on …
2024
8 citazioni
Clinical, cosmetic and …
2024
7 citazioni
Cureus
2023
9 citazioni
Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia.
Other
Journal of drugs …
2023
8 citazioni
Clinical, cosmetic and …
2023
8 citazioni
Dermatologic therapy
2022
41 citazioni
Expert opinion on …
2020
147 citazioni
Archives of dermatological …
2020
51 citazioni
Skin appendage disorders
2020
24 citazioni
Journal of cosmetic …
2019
100 citazioni
International journal of …
2012
69 citazioni
Evidence-based complementary and …
2011
27 citazioni
The Australasian journal …
2002
20 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 320 mg/day
- hairloss:
- 320 mg/day standardized extract
Limite massimo: Not established
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| 1 capsule daily (l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, micronutrien | 24 weeks | Positive | 80 |
| None | -- | Positive | -- |
| varies by remedy and study | -- | Positive | -- |
| various dietary supplements (Nutrafol, apple extract, tocotrienols, pumpkin seed oil, Cistanche/Lami | -- | Positive | 1658 |
| Various non-prescription agents: procyanidin, cetirizine, caffeine, Oryza sativa bran, pumpkin seed | -- | Positive | -- |
| None | -- | Positive | -- |
| USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu | -- | Positive | -- |
Momento migliore per l'assunzione: With meals to reduce gastrointestinal side effects
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Mild gastrointestinal upset (nausea, diarrhea)
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Rare: decreased libido
Interazioni note
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Oral contraceptives and hormone replacement therapy (anti-androgenic effects)
- ● Finasteride and dutasteride (additive 5-alpha-reductase inhibition)
Livello di assunzione massimo tollerabile: Not established
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Saw Palmetto help with Alopecia androgenetica?
Based on 22 studies with 2,123 participants, there is strong evidence from multiple clinical trials that Saw Palmetto may support Alopecia androgenetica management. Our evidence grade is A (Strong Evidence).
How much Saw Palmetto should I take for Alopecia androgenetica?
Studies have used various dosages. A commonly studied range is 320 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saw Palmetto?
Reported side effects may include Mild gastrointestinal upset (nausea, diarrhea), Headache, Dizziness, Rare: decreased libido. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saw Palmetto and Alopecia androgenetica?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 22 peer-reviewed studies with 2,123 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Alopecia androgenetica
Saw Palmetto per altre condizioni
References
- [1] Kevin T Nguyen et al.. Int J Dermatol. 2026. The Over-The-Counter Finasteride Alternative: A Critical Review of Saw Palmetto's Efficacy, Safety, and Regulatory Concerns. doi:10.1111/ijd.17987 PubMed
- [2] Azhar Ahmed et al.. Skin Appendage Disord. 2025. Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. doi:10.1159/000542876 PubMed
- [3] Jaime Piquero-Casals et al.. Skin Appendage Disord. 2025. Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, … doi:10.1159/000540081 PubMed
- [4] Behnam Hasannejad-Asl et al.. Front Bioinform. 2025. Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques. doi:10.3389/fbinf.2025.1570101 PubMed
- [5] David Broadley et al.. Int J Cosmet Sci. 2025. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … doi:10.1111/ics.70035 PubMed
- [6] Massimo Milani et al.. J Cosmet Dermatol. 2025. Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real-Life, Multicenter, Randomized, Assessor-Blinded Trial … doi:10.1111/jocd.70388 PubMed
- [7] Aditya K Gupta et al.. Skin Appendage Disord. 2025. Do Non-Prescription Products Help in Managing Androgenic Alopecia? doi:10.1159/000542880 PubMed
- [8] Adam Leavitt et al.. J Drugs Dermatol. 2025. Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. doi:10.36849/JDD.8763 PubMed
- [9] Lei Zhou et al.. Front Nutr. 2025. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. doi:10.3389/fnut.2025.1719711 PubMed
- [10] Promise Ufomadu. Proc (Bayl Univ Med Cent). 2024. Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia. doi:10.1080/08998280.2023.2263829 PubMed
- [11] Aditya K Gupta et al.. Expert Opin Emerg Drugs. 2024. Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia. doi:10.1080/14728214.2024.2346590 PubMed
- [12] Nouf F Bin Rubaian et al.. Clin Cosmet Investig Dermatol. 2024. An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, with Special Emphasis on Rosemary Oil. doi:10.2147/CCID.S470989 PubMed
- [13] Pavithra Tr et al.. Cureus. 2023. A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma … doi:10.7759/cureus.38696 PubMed
- [14] Jeffrey Rapaport et al.. J Drugs Dermatol. 2023. Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia. doi:10.36849/JDD.7403 PubMed
- [15] Heggar Venkataramana Sudeep et al.. Clin Cosmet Investig Dermatol. 2023. Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic … doi:10.2147/CCID.S435795 PubMed
- [16] Aditya K Gupta et al.. Dermatol Ther. 2022. Natural products for male androgenetic alopecia. doi:10.1111/dth.15323 PubMed
- [17] Katherine York et al.. Expert Opin Pharmacother. 2020. A review of the treatment of male pattern hair loss. doi:10.1080/14656566.2020.1721463 PubMed
- [18] Ana Zgonc Škulj et al.. Arch Dermatol Res. 2020. Herbal preparations for the treatment of hair loss. doi:10.1007/s00403-019-02003-x PubMed
- [19] Evyatar Evron et al.. Skin Appendage Disord. 2020. Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. doi:10.1159/000509905 PubMed
- [20] Maria Yusuf Dhariwala et al.. J Cosmet Dermatol. 2019. An overview of herbal alternatives in androgenetic alopecia. doi:10.1111/jocd.12930 PubMed
- [21] A Rossi et al.. Int J Immunopathol Pharmacol. 2012. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. doi:10.1177/039463201202500435 PubMed
- [22] Sridar Chittur et al.. Evid Based Complement Alternat Med. 2011. Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic Acid and saw palmetto extract. doi:10.1093/ecam/nep102 PubMed
- [23] Rodney D Sinclair et al.. Australas J Dermatol. 2002. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia. doi:10.1046/j.1440-0960.2002.00620.x PubMed
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