Microneedling untuk Alopecia Areata

Berdasarkan 32 studi (1 meta-analysis, 9 RCTs) dengan 1,908 peserta secara total. 25/32 studi menunjukkan efek positif.

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Kesimpulan

Microneedling has strong evidence for supporting hair regrowth in alopecia areata, especially when combined with topical medications, and is backed by multiple randomized controlled trials.

25 out of 32 studies show positive effects, with 9 RCTs providing robust evidence
Works by creating micro-injuries that stimulate healing responses and improve drug absorption
Most effective when combined with topical agents like corticosteroids or vitamin D3
Both professional clinical procedures and at-home derma rollers have been studied

Key Study Findings

scoping_review n=16

A Scoping Review of Exosome Delivery Applications in Hair Loss.

Dose: variable; exosomes predominantly from mesenchymal stem cells (MSCs) vs: Placebo Efek: None None

retrospective cohort n=7 Open-label

Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study.

Dose: Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip vs: Placebo Efek: 85.7% achieved complete recovery; 14.3% achieved >50% regrowth; significant SALT score improvement None

Review

Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven …

Dose: None vs: Placebo Efek: None None

randomized controlled trial n=24 18 weeks Open-label

A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment …

Dose: Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals vs: Placebo Efek: Comparable efficacy between FRM and ILCS; nonsignificant differences in trichoscopic scores, PGA, an None

review

The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.

Dose: Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera vs: Placebo Efek: Positive outcomes reported for hair density and thickness with microneedling, lasers, LLLT, and PRP None

animal study 2 weeks

Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing …

Dose: Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment vs: Placebo Efek: Microneedling enhanced hair growth; restored gut microbiome diversity; reduced acetic acid and propa None

Key Statistics

Studi

1908

Peserta

↑

Positive

Peringkat

Referenced Papers

A Scoping Review of Exosome Delivery Applications in Hair Loss. Review

Cureus 2025 7 sitasi

Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation. Review

Aesthetic plastic surgery 2025 2 sitasi

Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study. Other

Journal of cosmetic … 2025 1 sitasi

The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia. Review

Italian journal of … 2025

Microinfusion of medications into the skin as a drug delivery technique: a narrative review. Other

Dermatology reports 2025

A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment of Alopecia Areata. RCT

Dermatologic surgery : … 2025

Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing and metabolomics. Other

Frontiers in microbiology 2025

The role of laser and energy-assisted drug delivery in the treatment of alopecia. Review

Lasers in medical … 2024 10 sitasi

Growth Factors and Microneedling in Alopecia Areata: A Narrative Review. Review

Skin appendage disorders 2024 5 sitasi

Comparison between melatonin versus melatonin and photobiomodulation versus photobiomodulation in the treatment of Alopecia X in German Spitz dogs: Clinical, … Other

PloS one 2024 4 sitasi

Effect of minoxidil combined with triamcinolone acetonide on alopecia areata by microneedle injection. Other

Skin research and … 2024 3 sitasi

Cosmetic filler-induced hair loss: case series and literature review. Case Report

The Journal of … 2024 2 sitasi

Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized … RCT

Journal of cosmetic … 2023 8 sitasi

Efficacy, safety, and Pharmacoeconomics of Three Common Strategies for Pediatric Alopecia Areata Patients: A Retrospective Cohort Study. Other

Clinical, cosmetic and … 2023 3 sitasi

Microneedling and Its Use in Hair Loss Disorders: A Systematic Review. Review

Dermatology and therapy 2022 43 sitasi

Clinical efficacy of adipocyte-derived stem cells conditioned media combined with micro-injury in refractory patch of alopecia areata. Other

Archives of dermatological … 2022 16 sitasi

Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata. RCT

The Journal of … 2022 9 sitasi

Fractional CO2 laser versus microneedling as a transepidermal drug delivery system for the treatment of alopecia areata: A clinical dermoscopic … RCT

Dermatologic therapy 2022 9 sitasi

Microneedling combined with compound betamethasone in treatment of severe alopecia areata: A case report. Case Report

Frontiers in immunology 2022 8 sitasi

Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant … RCT

Dermatologic therapy 2022 8 sitasi

Comparative Efficacy of Injection Triamcinolone Acetonide given Intralesionally and through Microneedling in Alopecia areata. Other

International journal of … 2022 1 sitasi

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series. Review

Aesthetic plastic surgery 2021 8 sitasi

Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single-blinded randomized … RCT

Dermatologic therapy 2021 7 sitasi

Combination of photodynamic therapy with 5-aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our … Other

Clinical and experimental … 2020 27 sitasi

Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or … RCT

Acta dermatovenerologica Alpina, … 2020 24 sitasi

Adverse effects of platelet-rich plasma and microneedling. Other

Journal of the … 2020 10 sitasi

Ophiasis alopecia areata treated with microneedling. Case Report

Proceedings (Baylor University. … 2020 8 sitasi

Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases. Case Report

Skin appendage disorders 2020 6 sitasi

Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review. Review

Cureus 2019 18 sitasi

The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards … Review

Journal of cosmetic … 2019 14 sitasi

Microneedling for the treatment of hair loss? Review

Journal of the … 2018 114 sitasi

An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. Review

The journal of … 2018 25 sitasi

WITHDRAWN: An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata. Review

The Journal of … 2017 1 sitasi

Alopecia areata-successful outcome with microneedling and triamcinolone acetonide. Other

Journal of cutaneous … 2014 80 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

hairloss:: 1.5 mm depth, weekly sessions

Batas atas: Not applicable

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
variable; exosomes predominantly from mesenchymal stem cells (MSCs)	--	Positive	16
Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip	--	Positive	7
None	--	Mixed	--
Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals	18 weeks	Neutral	24
Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera	--	Positive	--
Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment	2 weeks	Positive	--
Microinfusion of medications into the skin (MMP) using tattoo devices; various drugs (minoxidil, ste	--	Positive	--
Melatonin 3 mg/kg; PBM diode laser 660nm, 100mW, 3 J/point, 2 sessions/week	12 weeks	Mixed	60

Waktu terbaik diminum: Weekly sessions; avoid minoxidil for 24 hours post-treatment

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Scalp redness and inflammation (24-72 hours)
⚠ Mild bleeding at treatment site
⚠ Scalp tenderness and soreness
⚠ Rare: infection if proper sterilization not maintained

Interaksi yang Diketahui

● Topical minoxidil (enhanced absorption; wait 24 hours after microneedling to apply)
● Blood thinners (may increase bleeding during procedure)
● Topical retinoids (discontinue 3-5 days before treatment)

Asupan atas yang dapat ditoleransi: Not applicable

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Microneedling help with Alopecia Areata?

Based on 34 studies with 1,908 participants, there is strong evidence from multiple clinical trials that Microneedling may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).

How much Microneedling should I take for Alopecia Areata?

Studies have used various dosages. A commonly studied range is 1.5 mm depth, weekly sessions. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Microneedling?

Reported side effects may include Scalp redness and inflammation (24-72 hours), Mild bleeding at treatment site, Scalp tenderness and soreness, Rare: infection if proper sterilization not maintained. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Microneedling and Alopecia Areata?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 1,908 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Alopecia Areata

Minoxidil A Vitamin D A Terapi PRP A Minyak Biji Hitam A Ginseng C Seng F

Microneedling untuk kondisi lain

Alopecia Androgenetik A

Kesimpulan Singkat

Berdasarkan 32 studi (1 meta-analysis, 9 RCTs) dengan 1,908 peserta secara total. 25/32 studi menunjukkan efek positif.

Evidence Strength92%

High confidence

Rincian Studi

RCT (7)Meta (0)Other (27)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Alopecia Areata

Pelajari Lebih Lanjut

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