Microneedling für Alopecia Areata
ABasierend auf 32 Studien (1 meta-analysis, 9 RCTs) mit 1,908 Teilnehmern insgesamt. 25/32 Studien zeigen positive Effekte.
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A
Fazit
Microneedling has strong evidence for supporting hair regrowth in alopecia areata, especially when combined with topical medications, and is backed by multiple randomized controlled trials.
- 25 out of 32 studies show positive effects, with 9 RCTs providing robust evidence
- Works by creating micro-injuries that stimulate healing responses and improve drug absorption
- Most effective when combined with topical agents like corticosteroids or vitamin D3
- Both professional clinical procedures and at-home derma rollers have been studied
Key Study Findings
scoping_review
n=16
A Scoping Review of Exosome Delivery Applications in Hair Loss.
Dose: variable; exosomes predominantly from mesenchymal stem cells (MSCs)
vs.: Placebo
Wirkung: None
None
retrospective cohort
n=7
Open-label
Combination Therapy With CGF and Microneedling-Assisted Compound Betamethasone for Resistant Alopecia Areata: A Pilot Study.
Dose: Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip
vs.: Placebo
Wirkung: 85.7% achieved complete recovery; 14.3% achieved >50% regrowth; significant SALT score improvement
None
Review
Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven …
Dose: None
vs.: Placebo
Wirkung: None
None
randomized controlled trial
n=24
18 weeks
Open-label
A Comparative Clinical and Trichoscopic Study Between Fractional Radiofrequency Microneedling Versus Intralesional Steroids in Treatment …
Dose: Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals
vs.: Placebo
Wirkung: Comparable efficacy between FRM and ILCS; nonsignificant differences in trichoscopic scores, PGA, an
None
review
The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.
Dose: Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera
vs.: Placebo
Wirkung: Positive outcomes reported for hair density and thickness with microneedling, lasers, LLLT, and PRP
None
animal study
2 weeks
Investigating the potential mechanism of microneedling in alopecia areata mice based on 16S rRNA sequencing …
Dose: Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment
vs.: Placebo
Wirkung: Microneedling enhanced hair growth; restored gut microbiome diversity; reduced acetic acid and propa
None
Key Statistics
34
Studien
1908
Teilnehmer
↑
Positive
A
Bewertung
Referenced Papers
Cureus
2025
7 Zitierungen
Aesthetic plastic surgery
2025
2 Zitierungen
Journal of cosmetic …
2025
1 Zitierungen
Italian journal of …
2025
Dermatology reports
2025
Dermatologic surgery : …
2025
Frontiers in microbiology
2025
Lasers in medical …
2024
10 Zitierungen
Skin appendage disorders
2024
5 Zitierungen
PloS one
2024
4 Zitierungen
Skin research and …
2024
3 Zitierungen
The Journal of …
2024
2 Zitierungen
Journal of cosmetic …
2023
8 Zitierungen
Clinical, cosmetic and …
2023
3 Zitierungen
Dermatology and therapy
2022
43 Zitierungen
Archives of dermatological …
2022
16 Zitierungen
Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata.
RCT
The Journal of …
2022
9 Zitierungen
Dermatologic therapy
2022
9 Zitierungen
Microneedling combined with compound betamethasone in treatment of severe alopecia areata: A case report.
Case Report
Frontiers in immunology
2022
8 Zitierungen
Dermatologic therapy
2022
8 Zitierungen
International journal of …
2022
1 Zitierungen
Aesthetic plastic surgery
2021
8 Zitierungen
Dermatologic therapy
2021
7 Zitierungen
Clinical and experimental …
2020
27 Zitierungen
Acta dermatovenerologica Alpina, …
2020
24 Zitierungen
Journal of the …
2020
10 Zitierungen
Proceedings (Baylor University. …
2020
8 Zitierungen
Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases.
Case Report
Skin appendage disorders
2020
6 Zitierungen
Cureus
2019
18 Zitierungen
Journal of cosmetic …
2019
14 Zitierungen
Journal of the …
2018
114 Zitierungen
The journal of …
2018
25 Zitierungen
The Journal of …
2017
1 Zitierungen
Journal of cutaneous …
2014
80 Zitierungen
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- hairloss:
- 1.5 mm depth, weekly sessions
Obergrenze: Not applicable
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| variable; exosomes predominantly from mesenchymal stem cells (MSCs) | -- | Positive | 16 |
| Concentrated growth factor (CGF) combined with microneedling-assisted compound betamethasone; multip | -- | Positive | 7 |
| None | -- | Mixed | -- |
| Fractional radiofrequency microneedling (FRM), 6 sessions with 3-week intervals | 18 weeks | Neutral | 24 |
| Various microtrauma procedures: microneedling, fractional/non-fractional lasers, contact immunothera | -- | Positive | -- |
| Halometasone topical applied every 2 days for 2 weeks after hand-held dermal microneedling treatment | 2 weeks | Positive | -- |
| Microinfusion of medications into the skin (MMP) using tattoo devices; various drugs (minoxidil, ste | -- | Positive | -- |
| Melatonin 3 mg/kg; PBM diode laser 660nm, 100mW, 3 J/point, 2 sessions/week | 12 weeks | Mixed | 60 |
Beste Einnahmezeit: Weekly sessions; avoid minoxidil for 24 hours post-treatment
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Scalp redness and inflammation (24-72 hours)
- ⚠ Mild bleeding at treatment site
- ⚠ Scalp tenderness and soreness
- ⚠ Rare: infection if proper sterilization not maintained
Bekannte Wechselwirkungen
- ● Topical minoxidil (enhanced absorption; wait 24 hours after microneedling to apply)
- ● Blood thinners (may increase bleeding during procedure)
- ● Topical retinoids (discontinue 3-5 days before treatment)
Tolerierbare Höchstaufnahmemenge: Not applicable
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Microneedling help with Alopecia Areata?
Based on 34 studies with 1,908 participants, there is strong evidence from multiple clinical trials that Microneedling may support Alopecia Areata management. Our evidence grade is A (Strong Evidence).
How much Microneedling should I take for Alopecia Areata?
Studies have used various dosages. A commonly studied range is 1.5 mm depth, weekly sessions. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Microneedling?
Reported side effects may include Scalp redness and inflammation (24-72 hours), Mild bleeding at treatment site, Scalp tenderness and soreness, Rare: infection if proper sterilization not maintained. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Microneedling and Alopecia Areata?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 34 peer-reviewed studies with 1,908 total participants. The overall direction of effect is positive.
Related Evidence
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Microneedling für andere Beschwerden
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