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Dutasteride untuk Alopecia Androgenetik

A

Berdasarkan 43 studi (7 meta-analyses, 1 RCT) dengan 12,060 peserta secara total. 34/43 studi menunjukkan efek positif.

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A

Kesimpulan

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

  • 34 out of 43 studies show positive effects across 12,060 participants
  • Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
  • Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
  • Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None Efek: None None

Populasi: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind
Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …
Dose: 0.2 mg dutasteride daily vs: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline Efek: 21.53 vs 5.96 hair count increase 0.0072

Populasi: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.
Dose: 3 sessions of dutasteride microinfusion (monthly) vs: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment Efek: None None

Populasi: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label
Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …
Dose: 4 monthly sessions of SPi + iontophoresis vs: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … Efek: None <0.001 (density, diam, pull)

Populasi: 10 males + 10 postmenopausal females with resistant AGA

Review
Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.
Dose: Dutasteride (oral, various doses) vs: Placebo Efek: None None
Review
Male and female pattern hair loss.
Dose: None vs: Placebo Efek: None None

Key Statistics

99

Studi

19921

Peserta

Positive

A

Peringkat

Referenced Papers

Journal of cosmetic … 2025 3 sitasi
Australian prescriber 2025 2 sitasi
Journal of clinical … 2025 1 sitasi
Annals of dermatology 2025
Dermatology (Basel, Switzerland) 2024 14 sitasi
Journal of cosmetic … 2024 11 sitasi
Facial plastic surgery … 2024 8 sitasi
American journal of … 2023 41 sitasi
Fertility and sterility 2020 94 sitasi
Neurobiology of stress 2020 72 sitasi
Facial plastic surgery … 2020 15 sitasi
Alternative therapies in … 2020 11 sitasi
The aging male … 2019 19 sitasi
Assay and drug … 2019 19 sitasi
Expert opinion on … 2018 38 sitasi
Current clinical pharmacology 2017 62 sitasi
International journal of … 2017 45 sitasi
Actas dermo-sifiliograficas 2017 17 sitasi
The Cochrane database … 2016 18 sitasi
Indian journal of … 2016 8 sitasi
Current problems in … 2015 8 sitasi
Expert opinion on … 2014 57 sitasi
Current opinion in … 2014 43 sitasi
Dermatologic clinics 2013 78 sitasi
Journal of cosmetic … 2013 62 sitasi
Facial plastic surgery … 2013 16 sitasi
International journal of … 2013
Expert opinion on … 2010 264 sitasi
Current opinion in … 2009 54 sitasi
Seminars in cutaneous … 2009 4 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

hairloss:
0.5 mg/day (off-label)

Batas atas: 0.5 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis Durasi Efek N
None -- Neutral --
0.2 mg dutasteride daily 24 weeks Positive 139
3 sessions of dutasteride microinfusion (monthly) 12 weeks Positive 8
4 monthly sessions of SPi + iontophoresis 8 weeks Positive 20
Dutasteride (oral, various doses) -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --

Waktu terbaik diminum: Once daily at the same time, with or without food; prescription required

Safety & Side Effects

Efek Samping yang Dilaporkan

  • Decreased libido (more common than finasteride)
  • Erectile dysfunction
  • Ejaculation disorders
  • Gynecomastia (breast tissue growth)
  • Very long half-life (~5 weeks) means slow side effect resolution

Interaksi yang Diketahui

  • CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
  • May affect PSA levels (reduces by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

Asupan atas yang dapat ditoleransi: 0.5 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Dutasteride help with Alopecia Androgenetik?
Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that Dutasteride may support Alopecia Androgenetik management. Our evidence grade is A (Strong Evidence).
How much Dutasteride should I take for Alopecia Androgenetik?
Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Dutasteride?
Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Dutasteride and Alopecia Androgenetik?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.