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Dutasteride pour Alopécie Androgénétique

A

Basé sur 43 études (7 meta-analyses, 1 RCT) avec 12,060 participants au total. 34/43 études montrent des effets positifs.

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A

En conclusion

Dutasteride has strong scientific support for androgenetic alopecia and research suggests it may be more effective than finasteride, though it should be used under medical supervision due to potential side effects.

  • 34 out of 43 studies show positive effects across 12,060 participants
  • Multiple meta-analyses consistently support dutasteride's effectiveness for pattern hair loss
  • Blocks both type I and type II 5-alpha reductase enzymes, potentially offering broader DHT reduction than finasteride
  • Available in both oral and topical formulations, with topical forms being actively researched

Key Study Findings

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None Effet: None None

Population: women with androgenetic alopecia (female pattern hair loss)

Randomized Controlled Trial n=139 24 weeks Double-blind
Efficacy and Safety of Low-Dose (0.2 mg) Dutasteride for Male Androgenic Alopecia: A Multicenter, Randomized, …
Dose: 0.2 mg dutasteride daily vs: Placebo; 0.5 mg dutasteride daily Outcome: Change in hair count at vertex from baseline Effet: 21.53 vs 5.96 hair count increase 0.0072

Population: Men with androgenetic alopecia

Controlled Clinical Trial n=8 12 weeks Single-blind
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.
Dose: 3 sessions of dutasteride microinfusion (monthly) vs: Saline solution placebo via MMP Outcome: Clinical assessment and patient self-assessment Effet: None None

Population: Adult males with androgenetic alopecia

Other n=20 8 weeks Open-label
Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic …
Dose: 4 monthly sessions of SPi + iontophoresis vs: Baseline (pre-post design, no control) Outcome: Hair density, shaft diameter, pull test at 8 … Effet: None <0.001 (density, diam, pull)

Population: 10 males + 10 postmenopausal females with resistant AGA

Review
Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review.
Dose: Dutasteride (oral, various doses) vs: Placebo Effet: None None
Review
Male and female pattern hair loss.
Dose: None vs: Placebo Effet: None None

Key Statistics

99

Études

19921

Participants

Positive

A

Note

Referenced Papers

Journal of cosmetic … 2025 3 citations
Australian prescriber 2025 2 citations
Journal of clinical … 2025 1 citations
Annals of dermatology 2025
Dermatology (Basel, Switzerland) 2024 14 citations
Journal of cosmetic … 2024 11 citations
Facial plastic surgery … 2024 8 citations
American journal of … 2023 41 citations
Dermatology and therapy 2023 23 citations
Fertility and sterility 2020 94 citations
Neurobiology of stress 2020 72 citations
Facial plastic surgery … 2020 15 citations
Alternative therapies in … 2020 11 citations
Archivos espanoles de … 2020 1 citations
The aging male … 2019 19 citations
Assay and drug … 2019 19 citations
Expert opinion on … 2018 38 citations
Current clinical pharmacology 2017 62 citations
International journal of … 2017 45 citations
Actas dermo-sifiliograficas 2017 17 citations
The Cochrane database … 2016 18 citations
Indian journal of … 2016 8 citations
Current problems in … 2015 8 citations
Expert opinion on … 2014 57 citations
Current opinion in … 2014 43 citations
Dermatologic clinics 2013 78 citations
Journal of cosmetic … 2013 62 citations
Facial plastic surgery … 2013 16 citations
International journal of … 2013
Expert opinion on … 2010 264 citations
Current opinion in … 2009 54 citations
Seminars in cutaneous … 2009 4 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

hairloss:
0.5 mg/day (off-label)

Limite supérieure : 0.5 mg/day

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Neutral --
0.2 mg dutasteride daily 24 weeks Positive 139
3 sessions of dutasteride microinfusion (monthly) 12 weeks Positive 8
4 monthly sessions of SPi + iontophoresis 8 weeks Positive 20
Dutasteride (oral, various doses) -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --

Moment optimal de prise : Once daily at the same time, with or without food; prescription required

Safety & Side Effects

Effets indésirables signalés

  • Decreased libido (more common than finasteride)
  • Erectile dysfunction
  • Ejaculation disorders
  • Gynecomastia (breast tissue growth)
  • Very long half-life (~5 weeks) means slow side effect resolution

Interactions connues

  • CYP3A4 inhibitors (ketoconazole, ritonavir) may increase dutasteride levels
  • May affect PSA levels (reduces by ~50%)
  • Contraindicated in pregnancy (Category X teratogen)

Apport maximal tolérable : 0.5 mg/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Dutasteride help with Alopécie Androgénétique?
Based on 99 studies with 19,921 participants, there is strong evidence from multiple clinical trials that Dutasteride may support Alopécie Androgénétique management. Our evidence grade is A (Strong Evidence).
How much Dutasteride should I take for Alopécie Androgénétique?
Studies have used various dosages. A commonly studied range is 0.5 mg/day (off-label). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Dutasteride?
Reported side effects may include Decreased libido (more common than finasteride), Erectile dysfunction, Ejaculation disorders, Gynecomastia (breast tissue growth). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Dutasteride and Alopécie Androgénétique?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 99 peer-reviewed studies with 19,921 total participants. The overall direction of effect is positive.

Related Evidence

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.