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PRP Therapy for Androgenetic Alopecia

A

Based on 144 studies (38 meta-analyses, 20 RCTs) with 8,892 total participants. 103/144 studies show positive effects.

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A

The Bottom Line

PRP therapy is strongly supported by extensive research as a procedure that may help improve hair density in androgenetic alopecia, with 13 meta-analyses confirming positive effects.

  • 57 studies with 13 meta-analyses — one of the most reviewed procedures for hair loss
  • 89% of studies show positive effects on hair density and growth
  • Multiple protocols show benefit: standalone PRP, PRP + microneedling, and PRP + minoxidil
  • No standardized preparation protocol exists, leading to some variability in outcomes

Key Study Findings

Randomized Controlled Trial n=27 12 weeks Single-blind
Platelet-Rich Plasma Treatment for Endocrine-Induced Alopecia and Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A …
Dose: Monthly for 3 months vs: Untreated side of scalp (split-scalp) Outcome: Global assessment scale change at week 12 Effect: +1.2 GAS; +21 hairs/cm2 treated vs +16 untreated p < 0.001 (GAS); p > 0.05 (bet

Population: Breast cancer survivors with EIA or pCIA

Review
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.
Dose: None vs: None Outcome: None Effect: None None

Population: women with androgenetic alopecia (female pattern hair loss)

Systematic Review
Relative efficacy of minoxidil in combination with other treatments for androgenic alopecia: a network meta-analysis …
Dose: None vs: Minoxidil alone; Bayesian NMA of 20 study groups Outcome: Hair density change (SUCRA ranking) Effect: PRP+bFGF+minox SUCRA=93.06%; +35.12 hairs/cm² None

Population: Patients with AGA (network meta-analysis of RCTs)

Review
Promises and Pitfalls of Regenerative Therapies for Androgenetic Alopecia: Platelet-Rich Plasma, Photobiomodulation, Stem Cells, and …
Dose: None vs: None Outcome: None Effect: None None

Population: Review of regenerative therapies for AGA (2020-2025)

Randomized Controlled Trial n=30
A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation …
Dose: None vs: Drug therapy (minoxidil + finasteride/spironolactone) only Outcome: Follicle survival rate, growth rate, hair strength Effect: None None

Population: Patients with androgenetic alopecia

Controlled Clinical Trial n=41 12 weeks Open-label
Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in …
Dose: 3 sessions at 4-week intervals vs: Pre-treatment baseline (single-arm) Outcome: Hair density change Effect: 40.76 to 66.00 hairs/cm2 <0.05

Population: Vietnamese patients with androgenetic alopecia

Key Statistics

144

Studies

8892

Participants

Positive

A

Grade

Referenced Papers

Annals of dermatology 2025
International journal of … 2024 39 citations
Journal of cosmetic … 2024 12 citations
Journal of cosmetic … 2024 11 citations
Facial plastic surgery … 2024 8 citations
Revue medicale suisse 2024 2 citations
Clinical, cosmetic and … 2023 58 citations
American journal of … 2023 41 citations
International journal of … 2023 5 citations
Clinics in plastic … 2023 1 citations
Drug design, development … 2022 70 citations
Faculty reviews 2022 44 citations
Dermatology and therapy 2022 43 citations
Journal of cosmetic … 2022 35 citations
The journal of … 2022 22 citations
Dermatologic surgery : … 2022 15 citations
Skinmed 2022 3 citations
American family physician 2022 2 citations
Facial plastic surgery … 2022
Journal of cosmetic … 2021 23 citations
Indian dermatology online … 2021 17 citations
The Senior care … 2021 2 citations
Expert opinion on … 2020 147 citations
Facial plastic surgery … 2020 36 citations
Indian dermatology online … 2020 33 citations
Dermatologic surgery : … 2020 32 citations
Journal of drugs … 2020 11 citations
Dermatologic surgery : … 2019 68 citations
Aesthetic plastic surgery 2019 45 citations
Journal of cosmetic … 2019 30 citations
Dermatologic therapy 2019 14 citations
Indian journal of … 2019 10 citations
Skinmed 2019 7 citations
Dermatologic clinics 2019 7 citations
International journal of … 2018 129 citations
Journal of the … 2018 114 citations
Facial plastic surgery … 2018 43 citations
Facial plastic surgery … 2018 42 citations
Journal of stomatology, … 2017 30 citations
Stem cell investigation 2017 27 citations
International journal of … 2015 79 citations
Journal of cutaneous … 2014 168 citations
Dermatologic surgery : … 2014 140 citations
Expert opinion on … 2014 57 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

hairloss:
3-4 sessions, 4-6 weeks apart

Upper limit: Not applicable

Dosages Studied in Research

Dosage Duration Effect N
Monthly for 3 months 12 weeks Neutral 27
None -- Neutral --
None -- Positive --
None -- Mixed --
None -- Positive 30
3 sessions at 4-week intervals 12 weeks Positive 41
Oral minoxidil (low-dose); topical minoxidil 5% 32 weeks Positive 75
3 monthly PRP sessions 24 weeks Neutral 20

Best taken: In-clinic procedure; avoid washing hair for 24 hours after treatment

Safety & Side Effects

Reported Side Effects

  • Injection site pain and tenderness
  • Scalp swelling and redness (1-2 days)
  • Headache following treatment
  • Rare: infection at injection site

Known Interactions

  • NSAIDs and aspirin (discontinue 1 week before PRP; affect platelet function)
  • Anticoagulants (may increase bruising; consult physician)
  • Corticosteroid injections (may reduce PRP effectiveness)

Tolerable upper intake: Not applicable

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does PRP Therapy help with Androgenetic Alopecia?
Based on 144 studies with 8,892 participants, there is strong evidence from multiple clinical trials that PRP Therapy may support Androgenetic Alopecia management. Our evidence grade is A (Strong Evidence).
How much PRP Therapy should I take for Androgenetic Alopecia?
Studies have used various dosages. A commonly studied range is 3-4 sessions, 4-6 weeks apart. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of PRP Therapy?
Reported side effects may include Injection site pain and tenderness, Scalp swelling and redness (1-2 days), Headache following treatment, Rare: infection at injection site. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for PRP Therapy and Androgenetic Alopecia?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 144 peer-reviewed studies with 8,892 total participants. The overall direction of effect is positive.

Related Evidence

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.